Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Bill, Wickstead"'
Autor:
Thomas A Richards, Laura Eme, John M Archibald, Guy Leonard, Susana M Coelho, Alex de Mendoza, Christophe Dessimoz, Pavel Dolezal, Lillian K Fritz-Laylin, Toni Gabaldón, Vladimír Hampl, Geert J P L Kops, Michelle M Leger, Purificacion Lopez-Garcia, James O McInerney, David Moreira, Sergio A Muñoz-Gómez, Daniel J Richter, Iñaki Ruiz-Trillo, Alyson E Santoro, Arnau Sebé-Pedrós, Berend Snel, Courtney W Stairs, Eelco C Tromer, Jolien J E van Hooff, Bill Wickstead, Tom A Williams, Andrew J Roger, Joel B Dacks, Jeremy G Wideman
Publikováno v:
PLoS Biology, Vol 22, Iss 11, p e3002917 (2024)
Understanding the origin of eukaryotic cells is one of the most difficult problems in all of biology. A key challenge relevant to the question of eukaryogenesis is reconstructing the gene repertoire of the last eukaryotic common ancestor (LECA). As d
Externí odkaz:
https://doaj.org/article/81517f9828814b7fb85e2a6a375c29e7
Autor:
Eleanor Silvester, Balazs Szoor, Alasdair Ivens, Georgina Awuah-Mensah, Catarina Gadelha, Bill Wickstead, Keith R Matthews
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1011889 (2024)
Trypanosomatid parasites undergo developmental regulation to adapt to the different environments encountered during their life cycle. In Trypanosoma brucei, a genome wide selectional screen previously identified a regulator of the protein family ESAG
Externí odkaz:
https://doaj.org/article/d12859edc02f4c27a5132d16e0815e5b
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106410- (2023)
Summary: The eukaryotic BBSome is a transport complex within cilia and assembled by chaperonin-like BBS proteins. Recent work indicates nuclear functions for BBS proteins in mammals, but it is unclear how common these are in extant proteins or when t
Externí odkaz:
https://doaj.org/article/5b3a20f0342740d3975a4b68a4ccc704
Autor:
Jaime So, Sarah Sudlow, Abeer Sayeed, Tanner Grudda, Stijn Deborggraeve, Dieudonné Mumba Ngoyi, Didier Kashiama Desamber, Bill Wickstead, Veerle Lejon, Monica R. Mugnier
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Trypanosoma brucei gambiense is the primary causative agent of human African trypanosomiasis (HAT), a vector-borne disease endemic to West and Central Africa. The extracellular parasite evades antibody recognition within the host bloodstream
Externí odkaz:
https://doaj.org/article/0554be76d99843de9dd2daf7e05c92a2
Autor:
Hannah R. Belsham, Hanan M. Alghamdi, Nikita Dave, Alexandra J. Rathbone, Bill Wickstead, Claire T. Friel
Publikováno v:
Open Biology, Vol 12, Iss 8 (2022)
The activity of a kinesin is largely determined by the approximately 350 residue motor domain, and this region alone is sufficient to classify a kinesin as a member of a particular family. The kinesin-13 family are a group of microtubule depolymerizi
Externí odkaz:
https://doaj.org/article/2963415eaa13462580cabf2e44fe6b0d
Autor:
Pieter C Steketee, Emily A Dickie, James Iremonger, Kathryn Crouch, Edith Paxton, Siddharth Jayaraman, Omar A Alfituri, Georgina Awuah-Mensah, Ryan Ritchie, Achim Schnaufer, Tim Rowan, Harry P de Koning, Catarina Gadelha, Bill Wickstead, Michael P Barrett, Liam J Morrison
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009734 (2021)
Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucit
Externí odkaz:
https://doaj.org/article/d876db67785745d3836a0959a9e3e077
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Kinetochores perform an essential role in eukaryotes, coupling chromosomes to the mitotic spindle. In model organisms they are composed of a centromere-proximal inner kinetochore and an outer kinetochore network that binds to microtubules. In spite o
Externí odkaz:
https://doaj.org/article/df29969dab4f43b2ae577ff62ca0f200
Autor:
Georgina Awuah-Mensah, Jennifer McDonald, Pieter C Steketee, Delphine Autheman, Sarah Whipple, Simon D'Archivio, Cordelia Brandt, Simon Clare, Katherine Harcourt, Gavin J Wright, Liam J Morrison, Catarina Gadelha, Bill Wickstead
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009224 (2021)
Animal African trypanosomiasis (AAT) is a severe, wasting disease of domestic livestock and diverse wildlife species. The disease in cattle kills millions of animals each year and inflicts a major economic cost on agriculture in sub-Saharan Africa. C
Externí odkaz:
https://doaj.org/article/7e6c01a524a1497aa79b402dc4f32933
Autor:
Guy Leonard, Aurélie Labarre, David S. Milner, Adam Monier, Darren Soanes, Jeremy G. Wideman, Finlay Maguire, Sam Stevens, Divya Sain, Xavier Grau-Bové, Arnau Sebé-Pedrós, Jason E. Stajich, Konrad Paszkiewicz, Matthew W. Brown, Neil Hall, Bill Wickstead, Thomas A. Richards
Publikováno v:
Open Biology, Vol 8, Iss 1 (2018)
Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. The Fungi successf
Externí odkaz:
https://doaj.org/article/b7de941e0c82440f890bf08da75376ca
Autor:
Benoit Poulin, Eva-Maria Patzewitz, Declan Brady, Olivier Silvie, Megan H. Wright, David J. P. Ferguson, Richard J. Wall, Sarah Whipple, David S. Guttery, Edward W. Tate, Bill Wickstead, Anthony A. Holder, Rita Tewari
Publikováno v:
Biology Open, Vol 2, Iss 11, Pp 1160-1170 (2013)
Summary The phylum Apicomplexa comprises over 5000 intracellular protozoan parasites, including Plasmodium and Toxoplasma, that are clinically important pathogens affecting humans and livestock. Malaria parasites belonging to the genus Plasmodium pos
Externí odkaz:
https://doaj.org/article/c2a6927f08964f51b6261b8ba121c980