Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Bill, Deakin"'
Autor:
Sarah E. Herniman, Stephen J. Wood, Golam Khandaker, Paola Dazzan, Carmine M. Pariante, Nicholas M. Barnes, Carl R. Krynicki, Naghmeh Nikkheslat, Rachel C. Vincent, Alex Roberts, Annalisa Giordano, Andrew Watson, John Suckling, Thomas R. E. Barnes, Nusrat Husain, Peter B. Jones, Eileen Joyce, Stephen M. Lawrie, Shôn Lewis, Bill Deakin, Rachel Upthegrove, the BeneMin Study Team
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Attempts to delineate an immune subtype of schizophrenia have not yet led to the clear identification of potential treatment targets. An unbiased informatic approach at the level of individual immune cytokines and symptoms may reveal organis
Externí odkaz:
https://doaj.org/article/77b87667f96046caa3e615dd5523de90
Autor:
Francesca Perini, Jadwiga Maria Nazimek, Shane Mckie, Liliana P. Capitão, Jessica Scaife, Deepa Pal, Michael Browning, Gerard R. Dawson, Hiroyuki Nishikawa, Una Campbell, Seth C. Hopkins, Antony Loebel, Rebecca Elliott, Catherine J. Harmer, Bill Deakin, Kenneth S. Koblan
Publikováno v:
Schizophrenia, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Ulotaront, a trace amine-associated receptor 1 (TAAR1) and serotonin 5-HT1A receptor agonist without antagonist activity at dopamine D2 or the serotonin 5-HT2A receptors, has demonstrated efficacy in the treatment of schizophrenia. Here we r
Externí odkaz:
https://doaj.org/article/8e93de31cac74e1c866d57bdd55e4b8e
Autor:
Bence Bruncsics, Gabor Hullam, Bence Bolgar, Peter Petschner, Andras Millinghoffer, Kinga Gecse, Nora Eszlari, Xenia Gonda, Debra J. Jones, Sorrel T. Burden, Peter Antal, Bill Deakin, Gyorgy Bagdy, Gabriella Juhasz
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Manipulation of intake of serotonin precursor tryptophan has been exploited to rapidly induce and alleviate depression symptoms. While studies show that this latter effect is dependent on genetic vulnerability to depression, the effect of ha
Externí odkaz:
https://doaj.org/article/d90211f53735498d8257a1b5d6fd8a0b
Autor:
Zsuliet Kristof, Zsofia Gal, Dora Torok, Nora Eszlari, Sara Sutori, Beata Sperlagh, Ian M. Anderson, Bill Deakin, Gyorgy Bagdy, Gabriella Juhasz, Xenia Gonda
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 865 (2024)
Both early childhood traumatic experiences and current stress increase the risk of suicidal behaviour, in which immune activation might play a role. Previous research suggests an association between mood disorders and P2RX7 gene encoding P2X7 recepto
Externí odkaz:
https://doaj.org/article/b49298f8d48e44f18b0191fa7fde87de
Autor:
Stephen Burgess, Peter Jones, Rachel Upthegrove, Carmine Pariante, Graham K Murray, Anthony David, Martin Wilson, Nicholas Barnes, Paola Dazzan, John Suckling, Valeria Mondelli, Muzaffer Kaser, Neil Harrison, Georgios Gkoutos, Golam M Khandaker, Deepak Jadon, James MacCabe, Gary Donohoe, Alice Egerton, Bill Deakin, Jack Rogers, Éimear M Foley, Sian Lowri Griffiths, Alexander Murray, Fabiana Corsi-Zuelli, Hannah Hickinbotham, Ella Warwick, Nicholas M Barnes, Golam Khandaker, David Cotter, Ed Bullmore, Eva Meisenzahl, Joanna Neill, Nikos Koutsouleris, Stephen Wood
Publikováno v:
BMJ Open, Vol 13, Iss 3 (2023)
Introduction Evidence suggests a potentially causal role of interleukin 6 (IL-6), a pleiotropic cytokine that generally promotes inflammation, in the pathogenesis of psychosis. However, no interventional studies in patients with psychosis, stratified
Externí odkaz:
https://doaj.org/article/68df20bff4534eeebe80122791e23057
Autor:
Rebecca Owens, Rebecca Pollard, Richard Drake, Laura Kassoumeri, Shon Lewis, James MacCabe, Oliver D Howes, Edward Millgate, Eugenia Kravariti, Alice Egerton, Jane Lees, Bill Deakin, Kira Griffiths, Cecilia Casetta, Sobia Khan, Steve Lankshear, Elena Mikulskaya, Ebenezer Oloyede, Nathalie Rich, Sophie Smart, Aviv Segev, Kyra Verena Sendt
Publikováno v:
BMJ Open, Vol 12, Iss 11 (2022)
Objectives This prospective cohort study tested for associations between baseline cognitive performance in individuals early within their first episode and antipsychotic treatment of psychosis. We hypothesised that poorer cognitive functioning at the
Externí odkaz:
https://doaj.org/article/24b84b4f0e3248a4be25b8fa5a018358
Autor:
Ioanna A. Vamvakopoulou, Leon Fonville, Alexandra Hayes, John McGonigle, Rebecca Elliott, Karen D. Ersche, Remy Flechais, Csaba Orban, Anna Murphy, Dana G. Smith, John Suckling, Eleanor M. Taylor, Bill Deakin, Trevor W. Robbins, David J. Nutt, Anne R. Lingford-Hughes, Louise M. Paterson
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
IntroductionNegative affective states contribute to the chronic-relapsing nature of addiction. Mesolimbic dopamine D3 receptors are well placed to modulate emotion and are dysregulated in substance dependence. Selective antagonists might restore dopa
Externí odkaz:
https://doaj.org/article/4e8eb72042e4416497f16af44766cb8c
Autor:
Péter P. Ujma, Nóra Eszlári, András Millinghoffer, Bence Bruncsics, Dóra Török, Péter Petschner, Péter Antal, Bill Deakin, Gerome Breen, György Bagdy, Gabriella Juhász
Publikováno v:
Brain and Behavior, Vol 12, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Educational attainment is a substantially heritable trait, and it has recently been linked to specific genetic variants by genome‐wide association studies (GWASs). However, the effects of such genetic variants are expected to
Externí odkaz:
https://doaj.org/article/361c85f92e23431795abd9f73d6f0849
Autor:
Fabiana Corsi-Zuelli, Bill Deakin, Mikhael Haruo Fernandes de Lima, Omar Qureshi, Nicholas M. Barnes, Rachel Upthegrove, Paulo Louzada-Junior, Cristina Marta Del-Ben
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 17, Iss , Pp 100330- (2021)
Many studies have reported that patients with psychosis, even before drug treatment, have mildly raised levels of blood cytokines relative to healthy controls. In contrast, there is a remarkable scarcity of studies investigating the cellular basis of
Externí odkaz:
https://doaj.org/article/891ac20c78c44b8ebdaa041a364248a0
Autor:
Robin M Murray, Richard Drake, Stephen Lawrie, Laura Kassoumeri, James Walters, Shon Lewis, Anna Murphy, James MacCabe, Oliver D Howes, Edward Millgate, Eugenia Kravariti, Alice Egerton, Jacek Donocik, Tracy Collier, Jane Lees, Charlotte Stockton-Powdrell, Bill Deakin
Publikováno v:
BMJ Open, Vol 11, Iss 11 (2021)
Background 70%–84% of individuals with antipsychotic treatment resistance show non-response from the first episode. Emerging cross-sectional evidence comparing cognitive profiles in treatment resistant schizophrenia to treatment-responsive schizoph
Externí odkaz:
https://doaj.org/article/5c29a747d3fb491da3842a8728ebc56a