Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Bilikallahalli K. Muralidhara"'
Publikováno v:
Drug Discovery Today. 25:574-581
Biopharmaceuticals, unlike chemically synthesized small-molecule drugs, are marginally stable, with most of them requiring 3D structures to retain their activity and/or potency. This implies challenges to formulate these molecules for a shelf life >2
Autor:
Steve M. Bishop, Bilikallahalli K. Muralidhara, Wei Wang, Rinku Baid, Min Huang, Sandeep Nema
Publikováno v:
Drug Discovery Today. 21:430-444
Protein expression therapy using nucleic acid macromolecules (NAMs) as a new paradigm in medicine has recently gained immense therapeutic potential. With the advancement of nonviral delivery it has been possible to target NAMs against cancer, immunod
Autor:
Michael P. McCarthy, Corinne Cayatte, Kirsten Schneider-Ohrum, Bernardo Guzman, Gaurav Manohar Rajani, Vidyashankara Iyer, Bilikallahalli K. Muralidhara, Angie Snell, Ryan Matuszak
Publikováno v:
Human Vaccines & Immunotherapeutics. 11:1853-1864
Oil-in-water emulsions have gained consideration as vaccine adjuvants in recent years due to their ability to elicit a differentiated immunogenic response compared to traditional aluminum salt adjuvants. Squalene, a cholesterol precursor, is a natura
Autor:
Gaurav Manohar Rajani, Michael P. McCarthy, Steve M. Bishop, Richard L. Remmele, Corinne Cayatte, Bilikallahalli K. Muralidhara, Angie Snell Bennett, Vidyashankara Iyer, Jenny Sun, Sean K. Maynard, Kirsten Schneider-Ohrum, Jason D. Marshall
Publikováno v:
Journal of pharmaceutical sciences. 106(6)
To generate potent vaccine responses, subunit protein antigens typically require coformulation with an adjuvant. Oil-in-water emulsions are among the most widely investigated adjuvants, based on their demonstrated ability to elicit robust antibody an
Autor:
Bilikallahalli K. Muralidhara, Michael R. Schlittler, Qian Wang, Charles W. Demarest, Nathan A. Lacher, Serdar Aykent
Publikováno v:
Journal of Separation Science. 33:2671-2680
A rapid reversed-phase HPLC separation of recombinant human immunoglobulin gamma 2 (IgG2) disulfide isomers using columns packed with superficially porous particles is reported. Under optimal conditions, a separation of monoclonal IgG2 disulfide isom
Autor:
James R. Halpert, Santosh Kumar, Bilikallahalli K. Muralidhara, Numan Oezguen, Werner Braun, Aditya Hindupur
Publikováno v:
Journal of Biological Chemistry. 283:21808-21816
Using a multiple alignment of 175 cytochrome P450 (CYP) family 2 sequences, 20 conserved sequence motifs (CSMs) were identified with the program PCPMer. Functional importance of the CSM in CYP2B enzymes was assessed from available data on site-direct
Autor:
Bilikallahalli K. Muralidhara, Ling Sun, Surendra S. Negi, Santosh Kumar, Yonghong Zhao, James R. Halpert
Publikováno v:
Molecular Pharmacology. 72:1191-1199
Despite the emerging importance of human P450 2B6 in xenobiotic metabolism, thorough biochemical and biophysical characterization has been impeded as a result of low expression in Escherichia coli. Comparison with similar N-terminal truncated and C-t
Autor:
Qian, Wang, Nathan A, Lacher, Bilikallahalli K, Muralidhara, Michael R, Schlittler, Serdar, Aykent, Charles W, Demarest
Publikováno v:
Journal of separation science. 33(17-18)
A rapid reversed-phase HPLC separation of recombinant human immunoglobulin gamma 2 (IgG2) disulfide isomers using columns packed with superficially porous particles is reported. Under optimal conditions, a separation of monoclonal IgG2 disulfide isom
Autor:
Bilikallahalli K. Muralidhara, Stephen Durban, Colin D. Medley, Paul Robert Mehelic, Charles W. Demarest, Steven C. Chico
Publikováno v:
Analytical and bioanalytical chemistry. 398(1)
DNA-plasmid-based vaccines are a promising class of next generation therapeutics. Particle-mediated epidermal delivery is an attractive method for the administration of DNA plasmid vaccines. This technology utilizes minute quantities of DNA plasmid w
Autor:
James R. Halpert, C. David Stout, Bilikallahalli K. Muralidhara, Mark A. White, Santosh Kumar, Yonghong Zhao, Ling Sun
The crystal structure of P450 2B4 bound with 1-(4-chlorophenyl)imidazole (1-CPI) has been determined to delineate the structural basis for the observed differences in binding affinity and thermodynamics relative to 4-(4-chlorophenyl)imidazole (4-CPI)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3f7afc41c78eab49cf3d59a1833cea
https://europepmc.org/articles/PMC2566820/
https://europepmc.org/articles/PMC2566820/