Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Bilha Fischer"'
Publikováno v:
ACS Omega, Vol 5, Iss 48, Pp 31314-31322 (2020)
Externí odkaz:
https://doaj.org/article/f334b2f3f012465d82c66ed16b460288
Publikováno v:
European journal of medicinal chemistry. 244
For decades enzymatic hydrolysis of nucleotides, a cornerstone of life, was studied extensively along with the chemical hydrolytic reaction. The metabolic instability of nucleotides, in contrast with their enormous chemical stability, triggered devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff8747d91350fdccbef6da449ba8fea
https://pubmed.ncbi.nlm.nih.gov/36279693
https://pubmed.ncbi.nlm.nih.gov/36279693
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 48, Pp 31314-31322 (2020)
ACS Omega, Vol 5, Iss 48, Pp 31314-31322 (2020)
Uridine (U) mimetics are sought after as tools for biochemical and pharmacological studies. Previously, we have identified recognition patterns of U by proteins. Here, we targeted the characterization of uridine mimetics—cyanuryl-ribose (CR), barbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212fed7dc817f2c1c883547841f2f21c
http://europepmc.org/articles/PMC7726947
http://europepmc.org/articles/PMC7726947
Publikováno v:
Chemical Communications. 56:11633-11636
A new facile, rapid, stereo- and regio-selective one-pot synthesis of nucleoside-2',3'-O,O-phosphorothioate and selenoate analogs has been developed. This method avoids the need for protection strategies and chiral reagents, chiral metal catalysts, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d26904fc91e85f98b727c648c5b99eaf
https://doi.org/10.1039/d0cc02886j
https://doi.org/10.1039/d0cc02886j
DBU-assisted nucleophilic ring-opening of both uridine-5’-(2-thio-1,3,2-dithia-phospholane), 3, and uridine-(2-thio-1,3,2-oxathia-phospholane), 8, lasted 2 min at RT and resulted in quantitative yields of uridine-5’-phosphoro-di/trithioate esters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c2cdd63c5709164a4d25d935fd9c6f2
https://doi.org/10.26434/chemrxiv-2021-s0tlk
https://doi.org/10.26434/chemrxiv-2021-s0tlk
Publikováno v:
Current protocolsLiterature Cited. 1(11)
This article presents a new method for the rapid, stereoselective and regioselective synthesis of nucleoside 2',3'-O,O-phosphorothioate and 2',3'-O,O-phosphoroselenoate molecules. The method avoids the use of protection groups, chiral reagents, and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed88d5cfbb7ccde586e586c46d04014b
https://pubmed.ncbi.nlm.nih.gov/34826354
https://pubmed.ncbi.nlm.nih.gov/34826354
Autor:
Natalie Cohen, Linda J. W. Shimon, Bilha Fischer, Simone Dell'Acqua, Lior Elbaz, Thomas Jantz, Luigi Casella, Naomi Levy, Molhm Nassir, Eliana Lo Presti
Publikováno v:
Inorganic Chemistry. 58:8995-9003
Recently, we reported on a series of aminomethylene-phosphonate (AMP) analogues, bearing one or two heterocyclic groups on the aminomethylene moiety, as promising Zn(II) chelators. Given the strong Zn(II) binding properties of these compounds, they m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015b51b25e1842044c3c44499dd1aff1
https://doi.org/10.1021/acs.inorgchem.9b00287
https://doi.org/10.1021/acs.inorgchem.9b00287
Autor:
Bilha Fischer, Christian Renn, Salahuddin Mirza, Jean Sévigny, Sang-Yong Lee, Christa E. Müller, Uri Arad, Muhammad Rafehi, Julie Pelletier, Isaac Yaw Attah, Molhm Nassir, Herbert Zimmermann
Publikováno v:
Organic & Biomolecular Chemistry. 17:9913-9923
Nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) inhibitors have been suggested as a potential treatment for calcium pyrophosphate dihydrate (CPPD) deposition disease. Here, we targeted the development of improved NPP1 inhibitors based on acycli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7edb1359d333ea69722971e8fbc97909
https://doi.org/10.1039/c9ob02199j
https://doi.org/10.1039/c9ob02199j
Autor:
Noa Kinor, Melissa Wojtyniak, Bilha Fischer, Yaron Shav-Tal, Abed Saady, Christian Ducho, Verena Böttner, Eli Varon
Publikováno v:
Bioconjugate chemistry. 31(4)
Currently, there is demand for fluorescent oligonucleotide probes for diagnostic purposes. To address this necessity, we developed nucleosides containing a flexible spacer with an intercalating moiety at its end (NIC molecules). The intercalator is b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2521f43d00a948e881634fdd819f1378
https://pubmed.ncbi.nlm.nih.gov/32208683
https://pubmed.ncbi.nlm.nih.gov/32208683
Publikováno v:
Current Protocols in Nucleic Acid Chemistry. 80
Nucleoside intercalator conjugates (NICs) describe an innovative methodology developed in our research group for preparation of fluorescence turn-on DNA hybridization probes targeting specific mRNA sequences (e.g., breast cancer markers). In this met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d7edd9c8421473ab859816301c8ffe
https://doi.org/10.1002/cpnc.104
https://doi.org/10.1002/cpnc.104