Identification of bile acid-CoA:amino acid N-acyltransferase as the hepatic N-acyl taurine synthase for polyunsaturated fatty acids

Autor: Samuel A.J. Trammell, Luke F. Gamon, Kamil Gotfryd, Katja Thorøe Michler, Bandar D. Alrehaili, Iben Rix, Filip K. Knop, Pontus Gourdon, Yoon-Kwang Lee, Michael J. Davies, Matthew P. Gillum, Trisha J. Grevengoed

Publikováno v: Journal of Lipid Research, Vol 64, Iss 9, Pp 100361- (2023)

N-acyl taurines (NATs) are bioactive lipids with emerging roles in glucose homeostasis and lipid metabolism. The acyl chains of hepatic and biliary NATs are enriched in polyunsaturated fatty acids (PUFAs). Dietary supplementation with a class of PUFA

Externí odkaz: https://doaj.org/article/f84f1e3b40024fd5a3352b3eef7e65dc

Of mice and men: murine bile acids explain species differences in the regulation of bile acid and cholesterol metabolism[S]

Autor: Sara Straniero, Amit Laskar, Christina Savva, Jennifer Härdfeldt, Bo Angelin, Mats Rudling

Publikováno v: Journal of Lipid Research, Vol 61, Iss 4, Pp 480-491 (2020)

Compared with humans, rodents have higher synthesis of cholesterol and bile acids (BAs) and faster clearance and lower levels of serum LDL-cholesterol. Paradoxically, they increase BA synthesis in response to bile duct ligation (BDL). Another differe

Externí odkaz: https://doaj.org/article/da249c4ad2704e6e8aa69b69b72474f2

Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents

Autor: Masamichi Watanabe, Satoru Fukiya, Atsushi Yokota

Publikováno v: Journal of Lipid Research, Vol 58, Iss 6, Pp 1143-1152 (2017)

In addition to functioning as detergents that aid digestion of dietary lipids in the intestine, some bile acids have been shown to exhibit antimicrobial activity. However, detailed information on the bactericidal activities of the diverse molecular s

Externí odkaz: https://doaj.org/article/20c6336b040b48fd8e7e782cf207ac98

A Systems Analysis of Phenotype Heterogeneity in APOE*3Leiden.CETP Mice Induced by Long-Term High-Fat High-Cholesterol Diet Feeding

Autor: Yared Paalvast, Enchen Zhou, Yvonne J. W. Rozendaal, Yanan Wang, Albert Gerding, Theo H. van Dijk, Jan Freark de Boer, Patrick C. N. Rensen, Ko Willems van Dijk, Jan A. Kuivenhoven, Barbara M. Bakker, Natal A. W. van Riel, Albert K. Groen

Publikováno v: Nutrients; Volume 14; Issue 22; Pages: 4936
Nutrients, 14(22):4936. MDPI AG
Nutrients, 14(22):4936. Multidisciplinary Digital Publishing Institute (MDPI)
Nutrients, 14(22). MDPI

Within the human population, considerable variability exists between individuals in their susceptibility to develop obesity and dyslipidemia. In humans, this is thought to be caused by both genetic and environmental variation. APOE*3-Leiden.CETP mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0cd0d66ecfe9a0d37556a04d990ee3
https://pubmed.ncbi.nlm.nih.gov/36432620

Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport[S]

Autor: Eric J. Niesor, Christine Magg, Naoto Ogawa, Hiroshi Okamoto, Elisabeth von der Mark, Hugues Matile, Georg Schmid, Roger G. Clerc, Evelyne Chaput, Denise Blum-Kaelin, Walter Huber, Ralf Thoma, Philippe Pflieger, Makoto Kakutani, Daisuke Takahashi, Gregor Dernick, Cyrille Maugeais

Publikováno v: Journal of Lipid Research, Vol 51, Iss 12, Pp 3443-3454 (2010)

The mechanism by which cholesteryl ester transfer protein (CETP) activity affects HDL metabolism was investigated using agents that selectively target CETP (dalcetrapib, torcetrapib, anacetrapib). In contrast with torcetrapib and anacetrapib, dalcetr

Externí odkaz: https://doaj.org/article/6b0ce888f3634531a2b4ff3ba44e3457