Hydrophilic bile acids prevent liver damage caused by lack of biliary phospholipid in Mdr2−/− mice[S]

Autor: Renxue Wang, Jonathan A. Sheps, Lin Liu, Jun Han, Patrick S.K. Chen, Jason Lamontagne, Peter D. Wilson, Ian Welch, Christoph H. Borchers, Victor Ling

Publikováno v: Journal of Lipid Research, Vol 60, Iss 1, Pp 85-97 (2019)

Bile acid imbalance causes progressive familial intrahepatic cholestasis type 2 (PFIC2) or type 3 (PFIC3), severe liver diseases associated with genetic defects in the biliary bile acid transporter bile salt export pump (BSEP; ABCB11) or phosphatidyl

Externí odkaz: https://doaj.org/article/db1d6831af9842b0b39690e0a76d0744

Defective cholesterol metabolism in amyotrophic lateral sclerosis

Autor: Jonas Abdel-Khalik, Eylan Yutuc, Peter J. Crick, Jan-Åke Gustafsson, Margaret Warner, Gustavo Roman, Kevin Talbot, Elizabeth Gray, William J. Griffiths, Martin R. Turner, Yuqin Wang

Publikováno v: Journal of Lipid Research, Vol 58, Iss 1, Pp 267-278 (2017)

As neurons die, cholesterol is released in the central nervous system (CNS); hence, this sterol and its metabolites may represent a biomarker of neurodegeneration, including in amyotrophic lateral sclerosis (ALS), in which altered cholesterol levels

Externí odkaz: https://doaj.org/article/9d8e6d3705504fb48c95baea8195e5c8

The combination of ezetimibe and ursodiol promotes fecal sterol excretion and reveals a G5G8-independent pathway for cholesterol elimination[S]

Autor: Yuhuan Wang, Xiaoxi Liu, Sonja S. Pijut, Jianing Li, Jamie Horn, Emily M. Bradford, Markos Leggas, Terrence A. Barrett, Gregory A. Graf

Publikováno v: Journal of Lipid Research, Vol 56, Iss 4, Pp 810-820 (2015)

Previous studies suggest an interdependent relationship between liver and intestine for cholesterol elimination from the body. We hypothesized that a combination of ursodiol (Urso) and ezetimibe (EZ) could increase biliary secretion and reduce choles

Externí odkaz: https://doaj.org/article/330248f3a7df4cc1b7f68d5d1bc00d80

Rifampicin, not vitamin E, suppresses parenteral nutrition-associated liver disease development through the pregnane X receptor pathway in piglets

Autor: Gregory Guthrie, Charlotte Lauridsen, Douglas G. Burrin, Shaji Chacko, Barbara Stoll, Jogchum Plat

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology, 318(1), G41-G52. American Physiological Society
Guthrie, G, Stoll, B, Chacko, S, Lauridsen, C, Plat, J & Burrin, D G 2020, ' Rifampicin, not vitamin E, suppresses parenteral nutrition-associated liver disease development through the pregnane X receptor pathway in piglets ', American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 318, no. 1, pp. G41-G52 . https://doi.org/10.1152/ajpgi.00193.2019
Am J Physiol Gastrointest Liver Physiol

Infants receiving long-term parenteral nutrition (PN) develop PN-associated liver disease (PNALD). We previously (Ng K et al. JPEN J Parenter Enteral Nutr 40: 656–671, 2016. doi: 10.1177/0148607114567900 .) showed that PN containing soy-based lipid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d93c23b8e62b533153371662603600
https://doi.org/10.1152/ajpgi.00193.2019

A newborn screening method for cerebrotendinous xanthomatosis using bile alcohol glucuronides and metabolite ratios

Autor: Albert H. Bootsma, Andrea E. DeBarber, Hidde H. Huidekoper, Peter C. J. I. Schielen, Aad Verrips, Willem Kulik, Frédéric M. Vaz, Ron A. Wevers

Publikováno v: Journal of Lipid Research, 58, 1002-1007
Journal of Lipid Research, 58, 5, pp. 1002-1007
Journal of Lipid Research, 58(5), 1002-1007. American Society for Biochemistry and Molecular Biology Inc.
Journal of Lipid Research, Vol 58, Iss 5, Pp 1002-1007 (2017)
Journal of lipid research, 58(5), 1002-1007. American Society for Biochemistry and Molecular Biology Inc.

Contains fulltext : 174067.pdf (Publisher’s version ) (Open Access) Cerebrotendinous xanthomatosis (CTX) is a treatable neurodegenerative metabolic disorder of bile acid synthesis in which symptoms can be prevented if treatment with chenodeoxycholi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98fda6ad65248bd8cdc39337119cc2b
http://hdl.handle.net/2066/174067