Výsledky vyhledávání

Akademický článek

Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ.

Autor: Myers MC; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States. Electronic address: michael.myers@bms.com., Bilder DM; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States., Cavallaro CL; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States., Chao HJ; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States., Su S; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States., Burford NT; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States., Nayeem A; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States., Wang T; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States., Yan M; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States., Langish RA; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States., Dabros M; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States., Li YX; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States., Rose AV; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States., Behnia K; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States., Onorato JM; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States., Gargalovic PS; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States., Wexler RR; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States., Lawrence RM; Bristol-Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543, United States.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Apr 01; Vol. 30 (7), pp. 126955. Date of Electronic Publication: 2020 Jan 22.

Zobrazit plný text záznamu

Akademický článek

Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.

Autor: Sun LQ, Mull E, Zheng B, D'Andrea S, Zhao Q, Wang AX, Sin N, Venables BL, Sit SY, Chen Y, Chen J, Cocuzza A, Bilder DM, Mathur A; Department of Discovery Synthesis, Bristol-Myers Squibb Research and Development , Route 206 and Provinceline Road, Princeton, New Jersey 08543, United States., Rampulla R; Department of Discovery Synthesis, Bristol-Myers Squibb Research and Development , Route 206 and Provinceline Road, Princeton, New Jersey 08543, United States., Chen BC; Department of Discovery Synthesis, Bristol-Myers Squibb Research and Development , Route 206 and Provinceline Road, Princeton, New Jersey 08543, United States., Palani T; Biocon Bristol-Myers Squibb R&D Center , Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, India., Ganesan S; Biocon Bristol-Myers Squibb R&D Center , Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, India., Arunachalam PN; Biocon Bristol-Myers Squibb R&D Center , Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, India., Falk P, Levine S, Chen C, Friborg J, Yu F, Hernandez D, Sheaffer AK, Knipe JO, Han YH, Schartman R, Donoso M, Mosure K, Sinz MW, Zvyaga T, Rajamani R, Kish K, Tredup J, Klei HE, Gao Q; Department of Pharmaceutical Development, Bristol-Myers Squibb Research and Development , 1 Squibb Drive, New Brunswick, New Jersey 08903, United States., Ng A; Department of Pharmaceutical Development, Bristol-Myers Squibb Research and Development , 1 Squibb Drive, New Brunswick, New Jersey 08903, United States., Mueller L, Grasela DM, Adams S; Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534, United States., Loy J, Levesque PC; Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534, United States., Sun H; Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534, United States., Shi H; Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534, United States., Sun L; Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534, United States., Warner W; Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534, United States., Li D; Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534, United States., Zhu J; Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534, United States., Wang YK, Fang H, Cockett MI, Meanwell NA, McPhee F, Scola PM

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Sep 08; Vol. 59 (17), pp. 8042-60. Date of Electronic Publication: 2016 Aug 26.

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání