Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Bilash Kuila"'
Autor:
Milind Sagar, Amit Sharma, Dinesh Mahajan, Bilash Kuila, Sundeep Dugar, Somdutta Sen, Reena Arora, Amal Ray Mahapatra, Lalita Babasaheb Gawade
Publikováno v:
Journal of Medicinal Chemistry. 63:11121-11130
Herein, we report the identification and preclinical profile of a lead compound 10, (SPR519) as an equally potent dual inhibitor of PI3Kα and mTOR kinases. SPR519 exhibits an EC50 of low sub-micromolar range among various tested cancer cell lines su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190491610e3c416c5c12ea720f13c6ac
https://doi.org/10.1021/acs.jmedchem.0c01061
https://doi.org/10.1021/acs.jmedchem.0c01061
Publikováno v:
Synlett. 31:65-68
A nickel(0)-catalyzed intermolecular [3+2] cycloaddition of bis(alkylidenecyclopropanes) with diazenes such as diethyl or diisopropyl azodicarboxylate gave pyrazolidine-1,2-dicarboxylates in moderate to good yields (61–72%).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcc6e6315736b04e0c8cce587e4af740
https://doi.org/10.1055/s-0039-1691502
https://doi.org/10.1055/s-0039-1691502
Autor:
Chandrasekhar Abbineni, Leena Khare, Bilash Kuila, Abdul Rawoof Khaji, Dhaytadak Bhagwan Mahadeo, Sandeep Vitthal Dukare, Bhagya M S Kumar, Suraj T Gore, Vijay Kamal Ahuja, Amit A Dhudashiya, Raghavendra N R, Nagesh Gowda, Charamanna K B, Kiran Aithal B, Samiulla D S, Subhendu Mukherjee, Thomas Antony, Sanjeev Giri, Shekar Chelur, Kavitha Nellore, Girish Daginakatte, Murali Ramachandra, Susanta Samajdar
Publikováno v:
Cancer Research. 82:3729-3729
Background: The BAF (SWI/SNF) chromatin remodeling complex comprises of two mutually exclusive ATPases, SMARCA2 (BRM) and SMARCA4 (BRG1), that affect the mobilization and positioning of nucleosomes on DNA and thereby regulates important cellular func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43eab02d1cdc629559ec0922191e44b3
https://doi.org/10.1158/1538-7445.am2022-3729
https://doi.org/10.1158/1538-7445.am2022-3729
Rhodium-catalyzed intermolecular [3 + 2+2] cycloaddition reactions of bis(methylenecyclopropanes) with different alkynes are described. The rhodium-catalyzed [3 + 2+2] cycloadditions resulted in the formation of functionalized 5–7–3 spirocyclic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4d7b772adc03c26b5ea5d950cd2629
Publikováno v:
European Journal of Organic Chemistry. 2018:853-868
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bf4eb82914a7bb33e21f3cfa0ef8baa
https://doi.org/10.1002/ejoc.201701116
https://doi.org/10.1002/ejoc.201701116
Autor:
Subhendu Mukherjee, Susanta Samajdar, Sandeep Vitthal Dukare, Murali Ramachandra, Girish Daginakatte, Sanjeev Giri, Chandrasekhar Abbineni, M. R Sreevidya, Vijay Kamal Ahuja, Kiran Aithal, Charamanna Kb, Thomas Antony, DS Samiulla, Rakesh P. Nankar, Khaji Abdul Rawoof, Megha Goyal, Leena Khare Satyam, Suraj T. Gore, Bilash Kuila, Shekar Chelur, Ashok Ettam, Kavitha Nellore
Publikováno v:
Cancer Research. 81:1144-1144
Background: SMARCA2 (BRM) and SMARCA4 (BRG1) are two mutually exclusive DNA-dependent ATPases of the SWI/SNF complex, which function in mobilizing nucleosomes to regulate transcription, DNA replication/repair and chromosome dynamics. SMARCA4 is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14183647be6ef9b5b03e0005b4c444e4
https://doi.org/10.1158/1538-7445.am2021-1144
https://doi.org/10.1158/1538-7445.am2021-1144
Publikováno v:
Synlett. 29:509-512
Acetylenic ester promoted ring opening of dienyl-thiazolidin-4-ones and subsequent electrocyclization affords 5-phenyl-6-aryl pyridine-2-carboxylates in good to excellent yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f6ad894fbd593feab34344f9987eace
https://doi.org/10.1055/s-0036-1591721
https://doi.org/10.1055/s-0036-1591721
Publikováno v:
RSC Advances. 6:101587-101591
This manuscript describes a study on relatively unexplored halogen mediated 7-exo-dig/trig cyclization reactions of 2-(2-amino-aryl)-3-prop-2-ynyl/allyl-thiazolidin-4-ones for the formation of thiazole condensed 1,4-benzodiazepines in good yields. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::248655225078e1d7aaa531bb3a002a32
https://doi.org/10.1039/c6ra23493c
https://doi.org/10.1039/c6ra23493c
Publikováno v:
RSC Advances. 6:57485-57489
An efficient protocol for chemoselective synthesis of previously unknown 1,4-benzodiazepin-2-ones and dienyl thiazolidin-4-one carboxylates in excellent yields by ring transformation reactions of functionally decorated 2-azetidin-3-thiazolidin-4-ones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::844459449d13aa8f0ab6b7e19c3e7161
https://doi.org/10.1039/c6ra10021j
https://doi.org/10.1039/c6ra10021j
Publikováno v:
Synlett. 27:422-426
Tandem aza-Michael addition of 3-amino-2-azetidinones with acetylenic esters and subsequent intramolecular amidic ring opening of the initially formed azetidin-3-ylaminoprop- or -but-2-enoic ester is described. The reaction provides a facile route fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbfef9580a7e3f12dbe6bf05520da676
https://doi.org/10.1055/s-0035-1560826
https://doi.org/10.1055/s-0035-1560826