Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy

Autor: Bilal Khalil, Deepak Chhangani, Melissa C. Wren, Courtney L. Smith, Jannifer H. Lee, Xingli Li, Christian Puttinger, Chih-Wei Tsai, Gael Fortin, Dmytro Morderer, Junli Gao, Feilin Liu, Chun Kim Lim, Jingjiao Chen, Ching-Chieh Chou, Cara L. Croft, Amanda M. Gleixner, Christopher J. Donnelly, Todd E. Golde, Leonard Petrucelli, Björn Oskarsson, Dennis W. Dickson, Ke Zhang, James Shorter, Shige H. Yoshimura, Sami J. Barmada, Diego E. Rincon-Limas, Wilfried Rossoll

Publikováno v: Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-27 (2022)

Abstract Background Cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43) is a hallmark of the amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) disease spectrum, causing both nuclear loss-of-function an

Externí odkaz: https://doaj.org/article/bbd064334e3c44abbee70cb5d84f3100

Traffic jam at the nuclear pore: All roads lead to nucleocytoplasmic transport defects in ALS/FTD

Autor: Claudia Fallini, Bilal Khalil, Courtney L. Smith, Wilfried Rossoll

Publikováno v: Neurobiology of Disease, Vol 140, Iss , Pp 104835- (2020)

Amyotrophic lateral sclerosis (ALS) is a fatal late-onset neurodegenerative disease that specifically affects the function and survival of spinal and cortical motor neurons. ALS shares many genetic, clinical, and pathological characteristics with fro

Externí odkaz: https://doaj.org/article/579d7fa6d8064331b9276baf57ce95c2

New Distributional Record of Urentius hystricellus (Richter, 1870) (Hemiptera: Tingidae) from Southernmost Region of Punjab, Pakistan

Autor: Muhammad Tariq Rasheed, null Imran Bodlah, null Muhammad Qurban, null Muhammad Bilal Khalil, null Muhammad Usama Khalil, null Junaid Ali Siddiqui, null Ammara Gull E Fareen, null Muhammad Adnan Bodlah

Publikováno v: Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences. 59:93-97

Urentius hystricellus is well known phytophagous and invasive true bug of family Tingidae. From Pakistan, this family is poorly studied despite having significant economic importance. Present species was identified with the help of most relevant and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d1f6e1330f6955467af7b3e876516a0
https://doi.org/10.53560/ppasb(59-4)759

Identification of Novel Modifiers of Tau Aggregation and Pathology using a Proximity Proteomics Approach

Autor: Jannifer H Lee, Dmytro Morderer, Bilal Khalil, Feilin Liu, Chih‐Wei Tsai, Cara L Croft, Yari Carlomagno, Michael DeTure, Michelle Salemi, Casey Cook, Brett Phinney, Dennis W. Dickson, Todd E Golde, Leonard Petrucelli, Wilfried Rossoll

Publikováno v: Alzheimer's & Dementia. 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa40929443c34d8e19cf7533fda3c896
https://doi.org/10.1002/alz.065671

Sigma-1 receptor is a key genetic modulator in amyotrophic lateral sclerosis

Autor: Tangui Maurice, Julien Roussel, Jean-Charles Liévens, Véronique Viguier, Simon Couly, Bilal Khalil

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2020, 29 (4), pp.529-540. ⟨10.1093/hmg/ddz267⟩
Human Molecular Genetics, 2020, 29 (4), pp.529-540. ⟨10.1093/hmg/ddz267⟩

Sigma-1 receptor (S1R) is an endoplasmic reticulum (ER) chaperone that regulates mitochondrial respiration but also controls cellular defense against ER and oxidative stress. This makes S1R a potential therapeutic target in amyotrophic lateral sclero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d069210fd87dbc3aeaf607586da50e62
https://hal.archives-ouvertes.fr/hal-02360092/file/ADW10A0.pdf