Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Bilada Bilican"'
Autor:
Sergio Kaiser, Luqing Zhang, Brit Mollenhauer, Jaison Jacob, Simonne Longerich, Jorge Del-Aguila, Jacob Marcus, Neha Raghavan, David Stone, Olumide Fagboyegun, Douglas Galasko, Mohammed Dakna, Bilada Bilican, Mary Dovlatyan, Anna Kostikova, Jingyao Li, Brant Peterson, Michael Rotte, Vinicius Sanz, Tatiana Foroud, Samantha J. Hutten, Mark Frasier, Hirotaka Iwaki, Andrew Singleton, Ken Marek, Karen Crawford, Fiona Elwood, Mirko Messa, Pablo Serrano-Fernandez
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract The pathogenesis and clinical heterogeneity of Parkinson’s disease (PD) have been evaluated from molecular, pathophysiological, and clinical perspectives. High-throughput proteomic analysis of cerebrospinal fluid (CSF) opened new opportuni
Externí odkaz:
https://doaj.org/article/8a3707f40aec4528b1d8d9e56c321bac
Autor:
Rebekka Wegmann, Marilisa Neri, Sven Schuierer, Bilada Bilican, Huyen Hartkopf, Florian Nigsch, Felipa Mapa, Annick Waldt, Rachel Cuttat, Max R. Salick, Joe Raymond, Ajamete Kaykas, Guglielmo Roma, Caroline Gubser Keller
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-21 (2019)
Abstract We develop CellSIUS (Cell Subtype Identification from Upregulated gene Sets) to fill a methodology gap for rare cell population identification for scRNA-seq data. CellSIUS outperforms existing algorithms for specificity and selectivity for r
Externí odkaz:
https://doaj.org/article/39c1e83d8d7d43228770031c5358d8f1
Autor:
Jing Qiu, Jamie McQueen, Bilada Bilican, Owen Dando, Dario Magnani, Karolina Punovuori, Bhuvaneish T Selvaraj, Matthew Livesey, Ghazal Haghi, Samuel Heron, Karen Burr, Rickie Patani, Rinku Rajan, Olivia Sheppard, Peter C Kind, T Ian Simpson, Victor LJ Tybulewicz, David JA Wyllie, Elizabeth MC Fisher, Sally Lowell, Siddharthan Chandran, Giles E Hardingham
Publikováno v:
eLife, Vol 5 (2016)
Evolutionary differences in gene regulation between humans and lower mammalian experimental systems are incompletely understood, a potential translational obstacle that is challenging to surmount in neurons, where primary tissue availability is poor.
Externí odkaz:
https://doaj.org/article/c6d2491c1b8445d08c27122e7a5f0b19
Autor:
Bilada Bilican, Matthew R Livesey, Ghazal Haghi, Jing Qiu, Karen Burr, Rick Siller, Giles E Hardingham, David J A Wyllie, Siddharthan Chandran
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85932 (2014)
Widespread use of human pluripotent stem cells (hPSCs) to study neuronal physiology and function is hindered by the ongoing need for specialist expertise in converting hPSCs to neural precursor cells (NPCs). Here, we describe a new methodology to gen
Externí odkaz:
https://doaj.org/article/71432849ec4347e083d21fefa0fd69b9
Autor:
Agnes L Nishimura, Carole Shum, Emma L Scotter, Amr Abdelgany, Valentina Sardone, Jamie Wright, Youn-Bok Lee, Han-Jou Chen, Bilada Bilican, Monica Carrasco, Tom Maniatis, Siddharthan Chandran, Boris Rogelj, Jean-Marc Gallo, Christopher E Shaw
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91269 (2014)
TDP-43 is found in cytoplasmic inclusions in 95% of amyotrophic lateral sclerosis (ALS) and 60% of frontotemporal lobar degeneration (FTLD). Approximately 4% of familial ALS is caused by mutations in TDP-43. The majority of these mutations are found
Externí odkaz:
https://doaj.org/article/fa42f11aa6034af69f65a96cb5723752
Autor:
Bilada Bilican, Christelle Fiore-Heriche, Alastair Compston, Nicholas D Allen, Siddharthan Chandran
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2863 (2008)
During normal development oligodendrocyte precursors (OPCs) are generated in the ventral spinal cord in response to Sonic hedgehog (Shh) signalling. There is also a second, late wave of oligodendrogenesis in the dorsal spinal cord independent of Shh
Externí odkaz:
https://doaj.org/article/7c7e33269d7544dfb1b7b19f36c2e793
Autor:
Abhishek Nag, Ryan S. Dhindsa, Jonathan Mitchell, Chirag Vasavda, Andrew R. Harper, Dimitrios Vitsios, Andrea Ahnmark, Bilada Bilican, Katja Madeyski-Bengtson, Bader Zarrouki, Anthony W. Zoghbi, Quanli Wang, Katherine R. Smith, Jesus Alegre-Díaz, Pablo Kuri-Morales, Jaime Berumen, Roberto Tapia-Conyer, Jonathan Emberson, Jason M. Torres, Rory Collins, David M. Smith, Benjamin Challis, Dirk S. Paul, Mohammad Bohlooly-Y, Mike Snowden, David Baker, Regina Fritsche-Danielson, Menelas N. Pangalos, Slavé Petrovski
We performed collapsing analyses on 454,796 UK Biobank (UKB) exomes to detect gene-level associations with diabetes. Recessive carriers of nonsynonymous variants in MAP3K15 were 30% less likely to develop diabetes ( P = 5.7 × 10 −10 ) and had lowe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a682c76a1eca49d8219fc25c810730
https://doi.org/10.1126/sciadv.add5430
https://doi.org/10.1126/sciadv.add5430
Autor:
Abhishek, Nag, Ryan S, Dhindsa, Jonathan, Mitchell, Chirag, Vasavda, Andrew R, Harper, Dimitrios, Vitsios, Andrea, Ahnmark, Bilada, Bilican, Katja, Madeyski-Bengtson, Bader, Zarrouki, Anthony W, Zoghbi, Quanli, Wang, Katherine R, Smith, Jesus, Alegre-Díaz, Pablo, Kuri-Morales, Jaime, Berumen, Roberto, Tapia-Conyer, Jonathan, Emberson, Jason M, Torres, Rory, Collins, David M, Smith, Benjamin, Challis, Dirk S, Paul, Mohammad, Bohlooly-Y, Mike, Snowden, David, Baker, Regina, Fritsche-Danielson, Menelas N, Pangalos, Slavé, Petrovski
Publikováno v:
Science advances. 8(46)
We performed collapsing analyses on 454,796 UK Biobank (UKB) exomes to detect gene-level associations with diabetes. Recessive carriers of nonsynonymous variants in
Autor:
Mirko Messa, Sergio Kaiser, Luqing Zhang, Brit Mollenhauer, Jaison Jacob, Simonne Longerich, Jorge Del-Aguila, Jacob Marcus, Neha Raghavan, David Stone, Olumide Fagboyegun, Douglas Galasko, Mohammed Dakna, Bilada Bilican, Mary Dovlatyan, Anna Kostikova, Jingyao Li, Brant Peterson, Michael Rotte, Vinicius Sanz, Tatiana Foroud, Samantha Hutten, Mark Frasier, Hirotaka Iwaki, Andrew Singleton, Ken Marek, Karen Crawford, Fiona Elwood, Pablo Serrano-Fernandez
The pathogenesis and clinical heterogeneity of Parkinson’s disease have been evaluated from molecular, pathophysiological, and clinical perspectives. High-throughput proteomic analysis of CSF has opened new opportunities for scrutinizing this heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9403f02e95fb814b3145723ee4cdca8
https://doi.org/10.1101/2022.03.09.22272131
https://doi.org/10.1101/2022.03.09.22272131
Autor:
Benjamin Challis, Andrew R. Harper, David J. Smith, Menelas N. Pangalos, Mohammad Bohlooly-Y, Katherine R. Smith, Bader Zarrouki, Katja Madeyski-Bengtson, Dirk S. Paul, David Baker, Bilada Bilican, Andrea Ahnmark, Dimitrios Vitsios, Abhishek Nag, Mike Snowden, Regina Fritsche-Danielson, Quanli Wang, Ryan S. Dhindsa, Slavé Petrovski
Diabetes mellitus is a chronic health condition that can result in significant end-organ complications and is estimated to impact at least 8.5% of the global adult population. Here, we performed gene-level collapsing analysis on exome sequences from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0674becf0ec3222eca26279fed3d6ee
https://doi.org/10.1101/2021.11.14.21266328
https://doi.org/10.1101/2021.11.14.21266328