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Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma 1

Autor: Xie, Zhongjian J, Singleton, P A, Bourguignon, LYW, Bikle, D D

Publikováno v: Xie, Zhongjian J; Singleton, P A; Bourguignon, LYW; & Bikle, D D. (2005). Calcium-induced human keratinocyte differentiation requires src-and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma 1. Molecular Biology of the Cell, 16(7), 3236-3246. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7t44b6zq

We have previously demonstrated that phospholipase C (PLC)-gamma 1 is required for calcium-induced human keratinocyte differentiation. In the present study, we investigated whether the activation of PLC-gamma 1 by nonreceptor kinases such as src and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::2dc52c719e88f18f5225a4ee19a7d19d
http://www.escholarship.org/uc/item/7t44b6zq

The role of the calcium-sensing receptor in epidermal differentiation

Autor: Tu, Chia-Ling L, Oda, Y, Komuves, L, Bikle, D D

Publikováno v: Tu, Chia-Ling L; Oda, Y; Komuves, L; & Bikle, D D. (2004). The role of the calcium-sensing receptor in epidermal differentiation. Cell Calcium, 35(3), 265-273. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/5gj090x1

Calcium regulates the proliferation and differentiation of keratinocytes both in vivo and in vitro. Elevated extracellular Ca2+ concentration ([Ca2+](o)) raises the intracellular free calcium ([Ca2+](i)) and activates differentiation-related genes. C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::b997db0c786187f16b70b323a376138e
http://www.escholarship.org/uc/item/5gj090x1

The skin and vitamin D.

Autor: Bikle, D. D.

Publikováno v: Handbook of Diet, Nutrition & the Skin; 2012, p92-113, 22p