Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits

Autor: Christine E. Beattie, Sasha A Singh, Bikem Akten, Tanuja T. Merianda, Min Jeong Kye, Judith A. Steen, Mustafa Sahin, Duyu Nie, Jeffery L. Twiss, Le T. Hao, Jia Huang, Mary H. Wertz

Publikováno v: Proceedings of the National Academy of Sciences. 108:10337-10342

Spinal muscular atrophy (SMA), caused by the deletion of the SMN1 gene, is the leading genetic cause of infant mortality. SMN protein is present at high levels in both axons and growth cones, and loss of its function disrupts axonal extension and pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d02cce35bc258e462f75c7a1eb76b7
https://doi.org/10.1073/pnas.1104928108

SMN regulates axonal local translation via miR-183/mTOR pathway

Autor: Emily D. Niederst, Pierre Neveu, Kenneth S. Kosik, Markus Riessland, Mary H. Wertz, Bikem Akten, Brunhilde Wirth, Umrao R. Monani, Katarzyna Z. Dover, S. Pablo Sardi, Min Jeong Kye, Miriam Peters, Inês do Carmo G. Gonçalves, Marco A. Passini, Mustafa Sahin

Publikováno v: Kye, MJ; Niederst, ED; Wertz, MH; Goncalves, IDCG; Akten, B; Dover, KZ; et al.(2014). SMN regulates axonal local translation via miR-183/mTOR pathway. HUMAN MOLECULAR GENETICS, 23(23), 6318-6331. doi: 10.1093/hmg/ddu350. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/0wh5r5fc
Human molecular genetics, vol 23, iss 23

Reduced expression of SMN protein causes spinal muscular atrophy (SMA), a neurodegenerative disorder leading to motor neuron dysfunction and loss. However, the molecular mechanisms by which SMN regulates neuronal dysfunction are not fully understood.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525910f211fb9868d423317c3aa71fed
http://www.escholarship.org/uc/item/0wh5r5fc

Phosphoproteomics

Autor: Nurhan Ozlu, Bikem Akten, Wiebke Timm, Nathan Haseley, Hanno Steen, Judith A.J. Steen

Publikováno v: Wiley interdisciplinary reviews. Systems biology and medicine. 2(3)

Current analytical protein methods show phosphorylation to be the most ubiquitous, evolutionary conserved post-translational modification Post-Translational Modification (PTM). The reversible and transient nature of protein phosphorylation allows sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05fce6e29472823e8768863a5b2ba69
https://pubmed.ncbi.nlm.nih.gov/20836028

Genetic and Biochemical Strategies for Identifying Drosophila Genes That Function in Circadian Control

Autor: Bikem Akten, Yelena Kleyner, Vasudha Sundram, Ginka K. Genova, Joowon Suh, F. Rob Jackson, Mary A. Roberts, Yanmei Huang

Explicit biochemical models have been elaborated for the circadian oscillators of cyanobacterial, fungal, insect, and mammalian species. In contrast, much remains to be learned about how such circadian oscillators regulate rhythmic physiological proc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75a36aa002fd5f2587a593cebf70945c
https://doi.org/10.1016/s0076-6879(05)93035-8

Molecular analysis of the Drosophila miniature-dusky ( m-dy) gene complex: m-dy mRNAs encode transmembrane proteins with similarity to C. elegans cuticulin

Autor: Ginka K. Genova, Bikem Akten, S M DiBartolomeis, F. R. Jackson, Mary A. Roberts

Publikováno v: Molecular genetics and genomics : MGG. 267(5)

Mutations in the Drosophila miniature-dusky ( m-dy) gene complex were first reported by Morgan and Bridges about 90 years ago. m-dy mutants have abnormally small wings, a phenotype attributed to a cell-autonomous reduction in the size of the epiderma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15d2c561ba602f8a49f835beff9701d
https://pubmed.ncbi.nlm.nih.gov/12172795