Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Bikash R. Pattnaik"'
Autor:
Meha Kabra, Pawan K. Shahi, Yuyuan Wang, Divya Sinha, Allison Spillane, Gregory A. Newby, Shivani Saxena, Yao Tong, Yu Chang, Amr A. Abdeen, Kimberly L. Edwards, Cole O. Theisen, David R. Liu, David M. Gamm, Shaoqin Gong, Krishanu Saha, Bikash R. Pattnaik
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Clinical genome editing is emerging for rare disease treatment, but one of the major limitations is the targeting of CRISPR editors’ delivery. We delivered base editors to the retinal pigmented epithelium (RPE) in the mouse eye using silica nanocap
Externí odkaz:
https://doaj.org/article/3120d5bf8bdb4fc3874e0562564f1672
Autor:
Michael Landowski, Vijesh J. Bhute, Tetsuya Takimoto, Samuel Grindel, Pawan K. Shahi, Bikash R. Pattnaik, Sakae Ikeda, Akihiro Ikeda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Aging is a significant factor in the development of age-related diseases but how aging disrupts cellular homeostasis to cause age-related retinal disease is unknown. Here, we further our studies on transmembrane protein 135 (Tmem135), a gene
Externí odkaz:
https://doaj.org/article/d633aa25577040809a8ae0d6a88ae590
Autor:
Ismail S. Zaitoun, Pawan K. Shahi, Andrew Suscha, Kore Chan, Gillian J. McLellan, Bikash R. Pattnaik, Christine M. Sorenson, Nader Sheibani
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Ischemic stroke is a major cause of long-term disabilities, including vision loss. Neuronal and blood vessel maturation can affect the susceptibility of and outcome after ischemic stroke. Although we recently reported that exposure of neonat
Externí odkaz:
https://doaj.org/article/defc15708d154c2694a7566ad8ecf618
Autor:
Xiaodong Jiao, Zhiwei Ma, Jingqi Lei, Pinghu Liu, Xiaoyu Cai, Pawan K. Shahi, Chi-Chao Chan, Robert Fariss, Bikash R. Pattnaik, Lijin Dong, J. Fielding Hejtmancik
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
Purpose: We constructed and characterized knockout and conditional knockout mice for KCNJ13, encoding the inwardly rectifying K+ channel of the Kir superfamily Kir7.1, mutations in which cause both Snowflake Vitreoretinal Degeneration (SVD) and Retin
Externí odkaz:
https://doaj.org/article/e1616e19198b4cb4abfd674525a23606
Plumbagin-induced oxidative stress leads to inhibition of Na+/K+-ATPase (NKA) in canine cancer cells
Autor:
Yousef Alharbi, Arvinder Kapur, Mildred Felder, Lisa Barroilhet, Timothy Stein, Bikash R. Pattnaik, Manish S. Patankar
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract The Na+/K+-ATPase (NKA) complex is the master regulator of membrane potential and a target for anti-cancer therapies. Here, we investigate the effect of drug-induced oxidative stress on NKA activity. The natural product, plumbagin increases
Externí odkaz:
https://doaj.org/article/711cb0ad0da842b3aed61841711db73e
Autor:
Huan Yang, Yingmei Fu, Xinying Liu, Pawan K. Shahi, Timur A. Mavlyutov, Jun Li, Annie Yao, Steven Z.-W. Guo, Bikash R. Pattnaik, Lian-Wang Guo
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-15 (2017)
Abstract Background Retinitis pigmentosa (RP) is the most common inherited retinal degenerative disease yet with no effective treatment available. The sigma-1 receptor (S1R), a ligand-regulated chaperone, emerges as a potential retina-protective ther
Externí odkaz:
https://doaj.org/article/565262f5267641ab9d9168716c7ea62b
Autor:
Jaime E Brown, Breanna Aldred, Tyler Boulter, Rachel Sullivan, James Ver Hoeve, Bikash R Pattnaik, Melanie Schmitt
Publikováno v:
Ophthalmic Genetics. :1-5
Autor:
Katie M. Beverley, Bikash R. Pattnaik
Publikováno v:
American journal of physiology. Cell physiology. 323(3)
Channel proteins are vital for conducting ions throughout the body and are especially relevant to retina physiology. Inward rectifier potassium (Kir) channels are a class of K+ channels responsible for maintaining membrane potential and extracellular
Autor:
Onur E. Taparli, Pawan K. Shahi, Nur Sena Cagatay, Nur Aycan, Burak Ozaydin, Sefer Yapici, Xinying Liu, Ulas Cikla, Dila Zafer, Jens C. Eickhoff, Peter Ferrazzano, Bikash R. Pattnaik, Pelin Cengiz
Publikováno v:
Neurochemistry international.
The intricate system of connections between the eye and the brain implies that there are common pathways for the eye and brain that get activated following injury. Hypoxia-ischemia (HI) related encephalopathy is a consequence of brain injury caused b
Autor:
Yuyuan Wang, Bikash R. Pattnaik, Shaoqin Gong, Ruosen Xie, Min Wu, Seth Roge, Xiuxiu Wang, Yi Zhao, Pawan K Shahi
Publikováno v:
J Control Release
The rapid development of gene therapy and genome editing techniques brings up an urgent need to develop safe and efficient nanoplatforms for nucleic acids and CRISPR genome editors. Herein we report a stimulus-responsive silica nanoparticle (SNP) cap