Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Bikash Dangi"'
Autor:
Valentina Z. Petukhova, Sammy Y. Aboagye, Matteo Ardini, Rachel P. Lullo, Francesca Fata, Margaret E. Byrne, Federica Gabriele, Lucy M. Martin, Luke N. M. Harding, Vamshikrishna Gone, Bikash Dangi, Daniel D. Lantvit, Dejan Nikolic, Rodolfo Ippoliti, Grégory Effantin, Wai Li Ling, Jeremy J. Johnson, Gregory R. J. Thatcher, Francesco Angelucci, David L. Williams, Pavel A. Petukhov
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Only praziquantel is available for treating schistosomiasis, a disease affecting more than 200 million people. Praziquantel-resistant worms have been selected for in the lab and low cure rates from mass drug administration programs suggest t
Externí odkaz:
https://doaj.org/article/be068dfc60f64b079ddfa79996f6b0e8
Autor:
Dmitri R. Davydov, Bikash Dangi, Guihua Yue, Deepak S. Ahire, Bhagwat Prasad, Victor G. Zgoda
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 185 (2022)
Aiming to elucidate the system-wide effects of the alcohol-induced increase in the content of cytochrome P450 2E1 (CYP2E1) on drug metabolism, we explored the array of its protein-protein interactions (interactome) in human liver microsomes (HLM) wit
Externí odkaz:
https://doaj.org/article/6444d483dcc44f8dbd13dcbf1a4ad328
Publikováno v:
Xenobiotica
1. We closely characterized 7-Dimethylamino-4-trifluromethylcoumarin (Coumarin 152, C152), a substrate metabolized by multiple P450 species, to establish a new fluorogenic probe for the studies of functional integration in the cytochrome P450 ensembl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b45896467f77cb3b7842154455a39ce
https://doi.org/10.1080/00498254.2020.1775913
https://doi.org/10.1080/00498254.2020.1775913
Autor:
Valentina Petukhova, Samuel Aboagye, Matteo Ardini, Rachel Lullo, Margaret Byrne, Lucy Martin, Francesca Fata, Federica Gabriele, Rodolfo Ippoliti, Wai Li Ling, Grégory Effantin, Luke Harding, Dejan Nikolic, Daniel Lantvit, Bikash Dangi, Vamshikrishna Gone, Jeremy Johnson, Gregory Thatcher, Francesco Angelucci, David Williams, Pavel Petukhov
Only one drug, praziquantel, is available for treating schistosomiasis, a disease affecting more than 200 million people. Laboratory studies have shown that schistosome worms can develop resistance to praziquantel and low cure rates from mass drug ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d86a36268bc208b4a3a9fdecfc0b73
https://hdl.handle.net/11697/194259
https://hdl.handle.net/11697/194259
Autor:
Bikash Dangi, Victor G. Zgoda, Nikita E. Vavilov, Marc A. Maldonado, Nadezhda Y. Davydova, Dmitri R. Davydov
Publikováno v:
Biochem J
In this study, we investigate the ability of ethanol-inducible CYP2E1 to interact with other cytochrome P450 species and affect the metabolism of their substrates. As a model system, we used CYP2E1-enriched human liver microsomes (HLM) obtained by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1000e05c2303d3f1412760a5c2b437e1
https://doi.org/10.1042/bcj20190532
https://doi.org/10.1042/bcj20190532
Autor:
Dmitri R. Davydov, Bikash Dangi, Guihua Yue, Deepak S. Ahire, Bhagwat Prasad, Victor G. Zgoda
Publikováno v:
Biomolecules; Volume 12; Issue 2; Pages: 185
Aiming to elucidate the system-wide effects of the alcohol-induced increase in the content of cytochrome P450 2E1 (CYP2E1) on drug metabolism, we explored the array of its protein-protein interactions (interactome) in human liver microsomes (HLM) wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fc522deb17151a63c438b1b8c6c6fe
https://pubmed.ncbi.nlm.nih.gov/35204686
https://pubmed.ncbi.nlm.nih.gov/35204686
Aiming to elucidate the grounds of system-wide effects of the alcohol-induced increase in the content of cytochrome P450 2E1 (CYP2E1) on drug metabolism, we explored the array of its protein-protein interactions (proteome) in human liver microsomes (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e79153461f96deed04b8bed1edb98c4
https://doi.org/10.1101/2021.07.02.450960
https://doi.org/10.1101/2021.07.02.450960
Autor:
Chang Woo Lee, Eun-Ji Yu, Tae-Jin Oh, S. H. Park, Chang-Sook Jeong, Bikash Dangi, Jun Hyuck Lee, Ki-Hwa Kim, Hyun Soo Park
Publikováno v:
The FEBS Journal. 286:1683-1699
Bacterial cytochrome P450 (CYP) enzymes are involved in the hydroxylation of various endogenous substrates while using a heme molecule as a cofactor. CYPs have gained biotechnological interest as useful biocatalysts capable of altering chemical struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cabb8d79ba997f35875ee5f0d00ca4
https://doi.org/10.1111/febs.14729
https://doi.org/10.1111/febs.14729
Autor:
Tae-Jin Oh, Bikash Dangi
Publikováno v:
FEBS Letters. 593:67-79
Here, we report the first bacterial cytochrome P450, CYP154C8, that catalyzes the C-C bond cleavage reaction of steroids. A major change in product distribution is observed with CYP154C8, when the reactions are supported by NADPH and spinach redox pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d7a844676393c1147f430860dbbf93
https://doi.org/10.1002/1873-3468.13297
https://doi.org/10.1002/1873-3468.13297
Autor:
Nadezhda Y. Davydova, Bikash Dangi, Deepak Ahire, Marc A. Maldonado, Bhagwat Prasad, Dmitri R. Davydov
Publikováno v:
Arch Biochem Biophys
We investigated the correspondence between drug metabolism routes and the composition of the P450 ensemble in human liver microsomes (HLM). As a probe, we used Coumarin 152 (C152), a fluorogenic substrate metabolized by multiple P450 species. Studyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063d266b9611a7600d7cda90c45b8671
https://europepmc.org/articles/PMC8260145/
https://europepmc.org/articles/PMC8260145/