RNA-sequencing and bioinformatic analysis to pre-assess sensitivity to chemotherapeutics in GBM

Autor: Kantelhardt, SR, Kalasauskas, D, Sprang, B, Ringel, F, Bikar, SE, Naumann, N, Sorokin, M, Buzdin, A, Giese, A, Kim, E

Publikováno v: 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie; 20200621-20200624; sine loco [digital]; DOCV277 /20200626/

Objective: Development of a molecular guided approach for individualized selection of chemotherapeutics in (recurrent) GBM. In this EU-funded project high-throughput RNA sequencing and bioinformatics were utilized to quantitatively analyze activities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d93731e42f64f105417174e9f4faf54

Nanopore adaptive sampling of a metagenomic sample derived from a human monkeypox case.

Autor: Hewel C; Institute of Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Schmidt H; SARS-CoV-2 Sequencing Consortium Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.; Institute for Virology and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Runkel S; SARS-CoV-2 Sequencing Consortium Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.; Transfusion Unit & Test Center, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Kohnen W; SARS-CoV-2 Sequencing Consortium Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.; Department of Hygiene and Infection Prevention, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Schweiger-Seemann S; Institute of Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.; SARS-CoV-2 Sequencing Consortium Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Michel A; SARS-CoV-2 Sequencing Consortium Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.; Medical Management Department, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Bikar SE; SARS-CoV-2 Sequencing Consortium Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.; StarSEQ GmbH, Mainz, Germany., Lieb B; StarSEQ GmbH, Mainz, Germany., Plachter B; SARS-CoV-2 Sequencing Consortium Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.; Institute for Virology and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Hankeln T; SARS-CoV-2 Sequencing Consortium Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.; Faculty of Biology, Institute of Organismic and Molecular Evolution, Molecular Genetics & Genome Analysis, Johannes Gutenberg University of Mainz, Mainz, Germany., Linke M; Institute of Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.; SARS-CoV-2 Sequencing Consortium Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Gerber S; Institute of Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.; SARS-CoV-2 Sequencing Consortium Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Publikováno v: Journal of medical virology [J Med Virol] 2024 May; Vol. 96 (5), pp. e29610.

Intratumoral Heterogeneity and Longitudinal Changes in Gene Expression Predict Differential Drug Sensitivity in Newly Diagnosed and Recurrent Glioblastoma.

Autor: Kim EL; Clinic for Neurosurgery, Laboratory of Experimental Neurooncology, Johannes Gutenberg University Medical Centre, Langenbeckstrasse 1, 55124 Mainz, Germany., Sorokin M; Institute of Personalized Medicine, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.; Omicsway Corp., 340 S Lemon Ave, 6040, Walnut, CA 91789, USA., Kantelhardt SR; Clinic for Neurosurgery, Johannes Gutenberg University Medical Centre, Langenbeckstrasse 1, 55124 Mainz, Germany., Kalasauskas D; Clinic for Neurosurgery, Johannes Gutenberg University Medical Centre, Langenbeckstrasse 1, 55124 Mainz, Germany., Sprang B; Clinic for Neurosurgery, Laboratory of Experimental Neurooncology, Johannes Gutenberg University Medical Centre, Langenbeckstrasse 1, 55124 Mainz, Germany., Fauss J; Clinic for Neurosurgery, Laboratory of Experimental Neurooncology, Johannes Gutenberg University Medical Centre, Langenbeckstrasse 1, 55124 Mainz, Germany., Ringel F; Clinic for Neurosurgery, Johannes Gutenberg University Medical Centre, Langenbeckstrasse 1, 55124 Mainz, Germany., Garazha A; Omicsway Corp., 340 S Lemon Ave, 6040, Walnut, CA 91789, USA., Albert E; Institute of Personalized Medicine, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia., Gaifullin N; Department of Pathology, Faculty of Medicine, Lomonosov Moscow State University, 119991 Moscow, Russia., Hartmann C; Department of Neuropathology, Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany., Naumann N; StarSEQ GmbH, Joh.-Joachim-Becher-Weg 30a, 55128 Mainz, Germany., Bikar SE; StarSEQ GmbH, Joh.-Joachim-Becher-Weg 30a, 55128 Mainz, Germany., Giese A; OrthoCentrum Hamburg, Hansastrasse 1, 20149 Hamburg, Germany., Buzdin A; Institute of Personalized Medicine, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.; Oncobox Ltd., 121205 Moscow, Russia.; Moscow Institute of Physics and Technology, 141701 Moscow Region, Russia.

Publikováno v: Cancers [Cancers (Basel)] 2020 Feb 24; Vol. 12 (2). Date of Electronic Publication: 2020 Feb 24.