Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Bik-Kwoon Tye"'
Autor:
Bik-Kwoon Tye, Yuanliang Zhai
Publikováno v:
Biology, Vol 13, Iss 1, p 13 (2023)
Understanding human DNA replication through the study of yeast has been an extremely fruitful journey. The minichromosome maintenance (MCM) 2–7 genes that encode the catalytic core of the eukaryotic replisome were initially identified through forwa
Externí odkaz:
https://doaj.org/article/bee22c1d798f4d7a90571c1add4367d4
Autor:
Jiaxuan Cheng, Ningning Li, Yunjing Huo, Shangyu Dang, Bik-Kwoon Tye, Ning Gao, Yuanliang Zhai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The Dbf4-dependent kinase Cdc7 (DDK) is essential for eukaryotic DNA replication. Here, the authors present a series of cryo-EM structures elucidating the versatility of this kinase in exerting an ordered phosphorylation of its essential target to pr
Externí odkaz:
https://doaj.org/article/318d92e129594415b0f03782a6a4499e
Autor:
Clare S. K. Lee, Ming Fung Cheung, Jinsen Li, Yongqian Zhao, Wai Hei Lam, Vincy Ho, Remo Rohs, Yuanliang Zhai, Danny Leung, Bik-Kwoon Tye
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
In most model yeast species the Origin Recognition Complex (ORC) binds defined and species-specific base sequences while in humans what determines the binding appears to be more complex. Here the authors reveal that the yeast’s ORC complex binding
Externí odkaz:
https://doaj.org/article/f4ce881c9d4e4808a3ce45ff1501fdd0
Autor:
Jiaxuan Cheng, Ningning Li, Yunjing Huo, Shangyu Dang, Bik-Kwoon Tye, Ning Gao, Yuanliang Zhai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/1b285c98285c443c838ef2acc86aaab7
Publikováno v:
PLoS Genetics, Vol 6, Iss 5, p e1000946 (2010)
Eukaryotic chromosomes initiate DNA synthesis from multiple replication origins. The machinery that initiates DNA synthesis is highly conserved, but the sites where the replication initiation proteins bind have diverged significantly. Functional comp
Externí odkaz:
https://doaj.org/article/910ede6ff9a340368023a5016bf00188
Autor:
Jiaxuan Cheng, Ningning Li, Yunjing Huo, Shangyu Dang, Bik-Kwoon Tye, Ning Gao, Yuanliang Zhai
Publikováno v:
Nature communications. 13(1)
The Dbf4-dependent kinase Cdc7 (DDK) regulates DNA replication initiation by phosphorylation of the MCM double hexamer (MCM-DH) to promote helicase activation. Here, we determine a series of cryo electron microscopy (cryo-EM) structures of yeast DDK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96472c9ae5246aed79a34f32c2612617
https://pubmed.ncbi.nlm.nih.gov/35477717
https://pubmed.ncbi.nlm.nih.gov/35477717
Autor:
Yongqian Zhao, Clare S. K. Lee, Vincy Ho, Ming Fung Cheung, Remo Rohs, Yuanliang Zhai, Wai Hei Lam, Bik Kwoon Tye, Danny Leung, Jinsen Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
The Origin Recognition Complex (ORC) is an evolutionarily conserved six-subunit protein complex that binds specific sites at many locations to coordinately replicate the entire eukaryote genome. Though highly conserved in structure, ORC’s selectivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2942bba80adbe394679b71cd159992db
https://doi.org/10.1038/s41467-020-20277-y
https://doi.org/10.1038/s41467-020-20277-y
Autor:
Ningning Li, Ning Gao, Erchao Cheng, Wai Hei Lam, Yuanliang Zhai, Bik Kwoon Tye, Jiaxuan Cheng, Yongqian Zhao
Publikováno v:
Nature. 559:217-222
The six-subunit origin recognition complex (ORC) binds to DNA to mark the site for the initiation of replication in eukaryotes. Here we report a 3 Å cryo-electron microscopy structure of the Saccharomyces cerevisiae ORC bound to a 72-base-pair origi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689c62dff0774304eda5a511f3e12b27
https://doi.org/10.1038/s41586-018-0293-x
https://doi.org/10.1038/s41586-018-0293-x
Autor:
Ningning Li, Philip Y. K. Yung, Hao Wu, Yuanliang Zhai, Bik Kwoon Tye, Ning Gao, Erchao Cheng
Publikováno v:
Nature Structural & Molecular Biology. 24:300-308
A high-resolution cryo-EM structure of the heptameric Cdt1–Mcm2–7 complex of the replicative helicase from budding yeast suggests a ‘spring-action’ DNA-unwinding mechanism. The minichromosome maintenance complex (MCM) hexameric complex (Mcm2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadba18e3e6b5157e8edd6de6689e14a
https://doi.org/10.1038/nsmb.3374
https://doi.org/10.1038/nsmb.3374
Publikováno v:
Biophysical Journal. 118:160a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfda5c1d32359476628ef3d3a1b725b6
https://doi.org/10.1016/j.bpj.2019.11.990
https://doi.org/10.1016/j.bpj.2019.11.990