Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Biju Mangatt"'
Autor:
Christopher L. Carpenter, Eldridge N. Nartey, Dominic Suarez, Elisabeth A. Minthorn, Jesus R. Medina, Louis V. LaFrance, Ralph A. Rivero, James F. Mack, Charles F. McHugh, Xinrong Tian, Dirk A. Heerding, Christina Ng Di Marco, Thomas J. Berrodin, Aishwarya Bhaskar, Biju Mangatt, William Hoi Hong Li, Brackley James, Martyr Cuthbert, Lorena A. Kallal, Michael Butticello, Jacob Rubin
Publikováno v:
Journal of Medicinal Chemistry. 64:16056-16087
Elevated expression of the c-MYC oncogene is one of the most common abnormalities in human cancers. Unfortunately, efforts to identify pharmacological inhibitors that directly target MYC have not yet yielded a drug-like molecule due to the lack of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be3a3a04dfdce0aa0aa268d1655c5476
https://doi.org/10.1021/acs.jmedchem.1c01416
https://doi.org/10.1021/acs.jmedchem.1c01416
Autor:
Xinrong Tian, Dominic Suarez, Douglas Thomson, William Li, Elizabeth A. King, Louis LaFrance, Jeffrey Boehm, Linda Barton, Christina Di Marco, Cuthbert Martyr, Reema Thalji, Jesus Medina, Steven Knight, Dirk Heerding, Enoch Gao, Eldridge Nartey, Ted Cecconie, Christopher Nixon, Guofeng Zhang, Thomas J. Berrodin, Christopher Phelps, Amish Patel, Xiaopeng Bai, Ken Lind, Ninad Prabhu, Jeffrey Messer, Zhengrong Zhu, Lisa Shewchuk, Rob Reid, Alan P. Graves, Charles McHugh, Biju Mangatt
Publikováno v:
Journal of medicinal chemistry. 65(21)
E1A binding protein (p300) and CREB binding protein (CBP) are two highly homologous and multidomain histone acetyltransferases. These two proteins are involved in many cellular processes by acting as coactivators of a large number of transcription fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646b8bd1f0dea4957b345cc77c8b3999
https://pubmed.ncbi.nlm.nih.gov/36302181
https://pubmed.ncbi.nlm.nih.gov/36302181
Autor:
Kimberline Y. Gerrick, Jenny Laraio, Kelsey Annen, Hoang Tran, Marcus M. Fischer, Yevgeniy Freyman, Geeta Sharma, Isaac Bishof, Stephen Federowicz, Divya Pankajakshan, Claire L. Neilan, Biju Mangatt, Anthony Mazurek, Mark R. Lackner, Michael White, Zineb Mounir
Publikováno v:
Cancer Research. 83:1637-1637
Methylthioadenosine phosphorylase (MTAP) is co-deleted with the tumor suppressor CDKN2A in approximately 15% of solid tumors and can elicit dependency on methionine adenosyltransferase 2A (MAT2A) production of S-adenosyl methionine (SAM), the major m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52dcfbf3c9347d14e437737ba3007882
https://doi.org/10.1158/1538-7445.am2023-1637
https://doi.org/10.1158/1538-7445.am2023-1637
Autor:
Jesús R, Medina, Xinrong, Tian, William H, Li, Dominic, Suarez, James F, Mack, Louis, LaFrance, Cuthbert, Martyr, James, Brackley, Christina, Di Marco, Ralph, Rivero, Dirk A, Heerding, Charles, McHugh, Elisabeth, Minthorn, Aishwarya, Bhaskar, Jacob, Rubin, Michael, Butticello, Christopher, Carpenter, Eldridge N, Nartey, Thomas J, Berrodin, Lorena A, Kallal, Biju, Mangatt
Publikováno v:
Journal of medicinal chemistry. 64(21)
Elevated expression of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::30e906e5f811e1b96b38c311683c1ee4
https://pubmed.ncbi.nlm.nih.gov/34669409
https://pubmed.ncbi.nlm.nih.gov/34669409
Autor:
Paul Scott-Stevens, Qin Donghui, Allen Oliff, Andrew N. Hobbs, Yoshiaki Washio, Josh Cottom, Jennifer A. Borthwick, Julia Coggins, Robert J. Young, Biju Mangatt, Jordi Munoz-Muriedas, Paris Ward, Siegfried B. Christensen, Helen L. Evans, Jingsong Yang, Nino Campobasso, Graham L. Simpson, Julien Chabanet, Xuan Hong, Sophie M. Bertrand, Susan Chen, Helen C. Dawson
Publikováno v:
Journal of Medicinal Chemistry. 62:2154-2171
Abelson kinase (c-Abl) is a ubiquitously expressed, nonreceptor tyrosine kinase which plays a key role in cell differentiation and survival. It was hypothesized that transient activation of c-Abl kinase via displacement of the N-terminal autoinhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64687f04df163cae0b9f2c6dc35de00e
https://doi.org/10.1021/acs.jmedchem.8b01872
https://doi.org/10.1021/acs.jmedchem.8b01872
High-Throughput Screening and Triage Assays Identify Small Molecules Targeting c-MYC in Cancer Cells
Autor:
Jon-Paul Jaworski, Lisa A. Payne, Anna Waszkiewicz, Biju Mangatt, Anthony J. Jurewicz, Lorena A. Kallal, Jesus R. Medina, Pat Brady, Xin Zeng, Thomas J. Berrodin, Carolyn Doepner-Buser, Anthony Della Pietra
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(2)
While c-MYC is well established as a proto-oncogene, its structure and function as a transcription factor have made c-MYC a difficult therapeutic target. To identify small-molecule inhibitors targeting c-MYC for anticancer therapy, we designed a high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbee602aec0943dd6af57df9d435d52
https://pubmed.ncbi.nlm.nih.gov/33482073
https://pubmed.ncbi.nlm.nih.gov/33482073
Autor:
Kallal, Lorena A., Waszkiewicz, Anna, Jon-Paul Jaworski, Pietra, Anthony Della, Berrodin, Tom, Brady, Pat, Jurewicz, Anthony J., Zeng, Xin, Payne, Lisa, Medina, Jesús R., Doepner-Buser, Carolyn, Biju Mangatt
Supplemental material, sj-pdf-1-jbx-10.1177_2472555220985457 for High-Throughput Screening and Triage Assays Identify Small Molecules Targeting c-MYC in Cancer Cells by Lorena A. Kallal, Anna Waszkiewicz, Jon-Paul Jaworski, Anthony Della Pietra, Tom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1d52f21526c095048c780164829e038
Autor:
Anja Ruusulehto, Andrew J. Plodkowski, Victor D. Martinez, Roger S. Smith, Jason C. Chang, Marc Ladanyi, Maria E. Arcila, Henrik Edgren, Kenneth K.-S. Ng, Gopinath Ganji, Charles M. Rudin, Christopher Matheny, Joshua K. Sabari, Joseph Montecalvo, Huichun Tai, Romel Somwar, Lukas Delasos, Natasha Rekhtman, Alexander Drilon, Ryma Benayed, Gregory J. Riely, Biju Mangatt, Mark G. Kris, Morana Vojnic, William W. Lockwood, Patrice Desmeules
Publikováno v:
Cancer Discovery. 8:686-695
NRG1 rearrangements are oncogenic drivers that are enriched in invasive mucinous adenocarcinomas (IMA) of the lung. The oncoprotein binds ERBB3–ERBB2 heterodimers and activates downstream signaling, supporting a therapeutic paradigm of ERBB3/ERBB2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba87b5e5e83002dac2bfef7860f03a85
https://doi.org/10.1158/2159-8290.cd-17-1004
https://doi.org/10.1158/2159-8290.cd-17-1004
Autor:
Biju, Mangatt P, Pyroja, Sulaiman, Rajeshkumar, Neelimmathara V, Paulose, Cheramadathikudyil S *
Publikováno v:
In Hepatology Research 2001 21(2):136-146
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