Zobrazeno 1 - 10
of 10 405
pro vyhledávání: '"Bijlsma A"'
The quality of software produced by students is often poor. How to teach students to develop good quality software has long been a topic in computer science education and research. We must conclude that we still do not have a good answer to this ques
Externí odkaz:
http://arxiv.org/abs/2309.02221
Autor:
Andrea Vallés‐Martí, Richard R. deGoeij‐de Haas, Alex A. Henneman, Sander R. Piersma, Thang V. Pham, Jaco C. Knol, Joanne Verheij, Frederike Dijk, Hans Halfwerk, Elisa Giovannetti, Connie R. Jiménez, Maarten F. Bijlsma
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 2020-2041 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a limited number of known driver mutations but considerable cancer cell heterogeneity. Phosphoproteomics provides a direct read‐out of aberrant signaling and the resultant clinic
Externí odkaz:
https://doaj.org/article/e8ff82023c7546bf9b7c1d4e26f666f5
Publikováno v:
Informatics in Education, Vol 23, Iss 2, Pp 361-383 (2024)
This paper presents the first experiences of the use of an online open-source repository with programming exercises. The repository is independent of any specific teaching approach. Students can search for and select an exercise that trains the progr
Externí odkaz:
https://doaj.org/article/01b88784f2864753b491e003414827f4
Autor:
Joana Gonçalves, Joana D. Amaral, Rita Capela, Maria de Jesus Perry, Cláudia Braga, Maria Manuela Gaspar, Fátima M. Piedade, Lubertus Bijlsma, Antoni Roig, Sandra N. Pinto, Rui Moreira, Pedro Florindo, Cecília M. P. Rodrigues
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Inducing necroptosis in cancer cells has emerged as an effective strategy to overcome drug resistance. However, while organic small molecules have been extensively studied for this purpose, metal-based compounds have received relatively litt
Externí odkaz:
https://doaj.org/article/cfb9a99efa384c4998ddab96fc03402d
Autor:
Amber P. van der Zalm, Mark P. G. Dings, Paul Manoukian, Hannah Boersma, Reimer Janssen, Peter Bailey, Jan Koster, Danny Zwijnenburg, Richard Volckmann, Sanne Bootsma, Cynthia Waasdorp, Monique van Mourik, Dionne Blangé, Tom van den Ende, César I. Oyarce, Sarah Derks, Aafke Creemers, Eva A. Ebbing, Gerrit K. Hooijer, Sybren L. Meijer, Mark I. van Berge Henegouwen, Jan Paul Medema, Hanneke W. M. van Laarhoven, Maarten F. Bijlsma
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-11 (2024)
Abstract Background Despite the advent of neoadjuvant chemoradiotherapy (CRT), overall survival rates of esophageal adenocarcinoma (EAC) remain low. A readily induced mesenchymal transition of EAC cells contributes to resistance to CRT. Methods In th
Externí odkaz:
https://doaj.org/article/d7fc9df802d34addb7ab614129c458e9
Autor:
Dajia Liu, Amber P. van der Zalm, Jan Koster, Sanne Bootsma, Cesar Oyarce, Hanneke W.M. van Laarhoven, Maarten F. Bijlsma
Publikováno v:
Pharmacological Research, Vol 207, Iss , Pp 107315- (2024)
Epithelial-mesenchymal transition (EMT) has been identified as a driver of therapy resistance, particularly in esophageal adenocarcinoma (EAC), where transforming growth factor beta (TGF-β) can induce this process. Inhibitors of TGF-β may counterac
Externí odkaz:
https://doaj.org/article/693617776d904183909d7cef03180eb3
Autor:
Dajia Liu, Lihui Guo, Cynthia Waasdorp, Sybren L. Meijer, Sanne Bootsma, Cesar Oyarce, Maarten F. Bijlsma, Hanneke W.M. van Laarhoven
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 178, Iss , Pp 117261- (2024)
Background: Long-term anti-angiogenesis leads to pruned vasculature, densely deposited extracellular matrix (ECM), and consequently reduced chemotherapy delivery in esophagogastric cancer (EGC). To address this issue, we evaluated the efficacy of add
Externí odkaz:
https://doaj.org/article/4443b6f6d2ae4872bc3299247fbd9f68
Autor:
Michael W T Tanck, Matthijs C Brouwer, Diederik van de Beek, Merijn W Bijlsma, Nina S Groeneveld, Ingeborg E van Zeggeren, Steven L Staal
Publikováno v:
BMJ Open, Vol 14, Iss 8 (2024)
Objectives Diagnostic prediction models exist to assess the probability of bacterial meningitis (BM) in paediatric patients with suspected meningitis. To evaluate the diagnostic accuracy of these models in a broad population of children suspected of
Externí odkaz:
https://doaj.org/article/d29803df67484c7d9c1f693c02bc337d
Autor:
Kelly Boelaars, Ernesto Rodriguez, Zowi R. Huinen, Chang Liu, Di Wang, Babet O. Springer, Katarzyna Olesek, Laura Goossens-Kruijssen, Thomas van Ee, Dimitri Lindijer, Willemijn Tak, Aram de Haas, Laetitia Wehry, Joline P. Nugteren-Boogaard, Aleksandra Mikula, Charlotte M. de Winde, Reina E. Mebius, David A. Tuveson, Elisa Giovannetti, Maarten F. Bijlsma, Manfred Wuhrer, Sandra J. van Vliet, Yvette van Kooyk
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Despite recent advances in cancer immunotherapy, pancreatic ductal adenocarcinoma (PDAC) remains unresponsive due to an immunosuppressive tumor microenvironment, which is characterized by the abundance of cancer-associated fibroblasts (CAFs)
Externí odkaz:
https://doaj.org/article/89d397e7c86647f4a8efdf005a8b83cc
Autor:
Mark R. Garrelfs, Tuula Rinne, Jacquelien J. Hillebrand, Peter Lauffer, Merijn W. Bijlsma, Hedi L. Claahsen-van der Grinten, Nicole de Leeuw, Martijn J.J. Finken, Joost Rotteveel, Nitash Zwaveling-Soonawala, Max Nieuwdorp, A.S. Paul van Trotsenburg, Christiaan F. Mooij
Publikováno v:
JCRPE, Vol 16, Iss 1, Pp 95-101 (2024)
Isolated aldosterone synthase deficiency is a rare autosomal recessive disorder caused by pathogenic variants in CYP11B2, resulting in impaired aldosterone synthesis. We report on a neonate with isolated aldosterone synthase deficiency caused by a no
Externí odkaz:
https://doaj.org/article/6da2ce501da6495ab743ea29f1a57ab9