Mosaic and mixed HIV-1 glycoprotein nanoparticles elicit antibody responses to broadly neutralizing epitopes.

Autor: Brinkkemper M; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands., Kerster G; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands., Brouwer PJM; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America., Tran AS; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America., Torres JL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America., Ettema RA; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands., Nijhuis H; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands., Allen JD; School of Biological Sciences, University of Southampton, Southampton, United Kingdom., Zhu W; School of Biological Sciences, University of Southampton, Southampton, United Kingdom., Gao H; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America., Lee WH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America., Bijl TPL; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands., Snitselaar JL; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands., Burger JA; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands., Bontjer I; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands., Olijhoek W; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands., Ravichandran R; Department of Biochemistry, University of Washington, Seattle, Washington, United States of America.; Institute for Protein Design, University of Washington, Seattle, Washington, United States of America., van Breemen MJ; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands., Del Moral-Sánchez I; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands., Derking R; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands., Sliepen K; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands., Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America., Crispin M; School of Biological Sciences, University of Southampton, Southampton, United Kingdom., Montefiori DC; Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America., Claireaux M; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America., van Gils MJ; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands., King NP; Department of Biochemistry, University of Washington, Seattle, Washington, United States of America.; Institute for Protein Design, University of Washington, Seattle, Washington, United States of America., Sanders RW; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands.; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2024 Oct 03; Vol. 20 (10), pp. e1012558. Date of Electronic Publication: 2024 Oct 03 (Print Publication: 2024).

Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site.

Autor: Caniels TG; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Medina-Ramìrez M; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Zhang S; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA., Kratochvil S; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA., Xian Y; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA., Koo JH; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA., Derking R; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Samsel J; Vaccine Research Center (VRC), NIAID, NIH, Bethesda, MD, USA.; Institute for Biomedical Sciences, George Washington University, Washington, DC, USA., van Schooten J; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Pecetta S; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA., Lamperti E; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA., Yuan M; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA., Carrasco MR; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Del Moral Sánchez I; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Allen JD; School of Biological Sciences, University of Southampton, Southampton, UK., Bouhuijs JH; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Yasmeen A; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Ketas TJ; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Snitselaar JL; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Bijl TPL; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Martin IC; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Torres JL; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA., Cupo A; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Shirreff L; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA., Rogers K; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA., Mason RD; Vaccine Research Center (VRC), NIAID, NIH, Bethesda, MD, USA., Roederer M; Vaccine Research Center (VRC), NIAID, NIH, Bethesda, MD, USA., Greene KM; Duke University Medical Center, Durham, NC, USA., Gao H; Duke University Medical Center, Durham, NC, USA., Silva CM; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Baken IJL; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Tian M; Howard Hughes Medical Institute, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Alt FW; Howard Hughes Medical Institute, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Pulendran B; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA., Crispin M; School of Biological Sciences, University of Southampton, Southampton, UK., van Gils MJ; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands., Montefiori DC; Duke University Medical Center, Durham, NC, USA., McDermott AB; Vaccine Research Center (VRC), NIAID, NIH, Bethesda, MD, USA., Villinger FJ; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA., Koup RA; Vaccine Research Center (VRC), NIAID, NIH, Bethesda, MD, USA., Moore JP; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Klasse PJ; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., Ozorowski G; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA., Batista FD; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Wilson IA; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA.; Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, CA, USA., Ward AB; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA., Sanders RW; Amsterdam UMC, location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Amsterdam, Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, Netherlands.; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA.

Publikováno v: Science immunology [Sci Immunol] 2024 Aug 30; Vol. 9 (98), pp. eadk9550. Date of Electronic Publication: 2024 Aug 30.

Broad SARS-CoV-2 neutralization by monoclonal and bispecific antibodies derived from a Gamma-infected individual.

Autor: Guerra D; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Beaumont T; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Radić L; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Kerster G; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., van der Straten K; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands.; Amsterdam UMC, location University of Amsterdam, Department of Internal Medicine, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands., Yuan M; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Torres JL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Lee WH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Liu H; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Poniman M; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Bontjer I; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Burger JA; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Claireaux M; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Caniels TG; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Snitselaar JL; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Bijl TPL; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Kruijer S; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Gideonse D; Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), 3721 MA Bilthoven, the Netherlands., Sliepen K; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Eggink D; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands.; Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), 3721 MA Bilthoven, the Netherlands., de Bree GJ; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands.; Amsterdam UMC, location University of Amsterdam, Department of Internal Medicine, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Sanders RW; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands.; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA., van Gils MJ; Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands.

Publikováno v: IScience [iScience] 2023 Sep 22; Vol. 26 (10), pp. 108009. Date of Electronic Publication: 2023 Sep 22 (Print Publication: 2023).

Lassa virus glycoprotein nanoparticles elicit neutralizing antibody responses and protection.

Autor: Brouwer PJM; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands; Department of Integrative, Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Antanasijevic A; Department of Integrative, Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA., Ronk AJ; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77550, USA; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550, USA., Müller-Kräuter H; Institute of Virology, Philipps University Marburg, 35043 Marburg, Germany., Watanabe Y; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK., Claireaux M; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands., Perrett HR; Department of Integrative, Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Bijl TPL; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands., Grobben M; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands., Umotoy JC; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands., Schriek AI; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands., Burger JA; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands., Tejjani K; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands., Lloyd NM; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77550, USA; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550, USA., Steijaert TH; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands., van Haaren MM; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands., Sliepen K; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands., de Taeye SW; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands., van Gils MJ; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands., Crispin M; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK., Strecker T; Institute of Virology, Philipps University Marburg, 35043 Marburg, Germany., Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77550, USA; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550, USA., Ward AB; Department of Integrative, Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: andrew@scripps.edu., Sanders RW; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA. Electronic address: r.w.sanders@amsterdamumc.nl.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2022 Dec 14; Vol. 30 (12), pp. 1759-1772.e12. Date of Electronic Publication: 2022 Nov 17.

A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike.

Autor: Claireaux M; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., Caniels TG; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., de Gast M; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., Han J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Guerra D; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., Kerster G; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., van Schaik BDC; Bioinformatics Laboratory, Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam Institute for Public Health, Amsterdam, the Netherlands., Jongejan A; Bioinformatics Laboratory, Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam Institute for Public Health, Amsterdam, the Netherlands., Schriek AI; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., Grobben M; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., Brouwer PJM; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., van der Straten K; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands.; Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands., Aldon Y; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., Capella-Pujol J; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., Snitselaar JL; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., Olijhoek W; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., Aartse A; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands.; Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands., Brinkkemper M; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., Bontjer I; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., Burger JA; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., Poniman M; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., Bijl TPL; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., Torres JL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Copps J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Martin IC; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., de Taeye SW; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., de Bree GJ; Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Sliepen K; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands., van Kampen AHC; Bioinformatics Laboratory, Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam Institute for Public Health, Amsterdam, the Netherlands., Moerland PD; Bioinformatics Laboratory, Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam Institute for Public Health, Amsterdam, the Netherlands., Sanders RW; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands. r.w.sanders@amsterdamumc.nl.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands. r.w.sanders@amsterdamumc.nl.; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA. r.w.sanders@amsterdamumc.nl., van Gils MJ; Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection prevention, Laboratory of Experimental Virology, Amsterdam, the Netherlands. m.j.vangils@amsterdamumc.nl.; Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, the Netherlands. m.j.vangils@amsterdamumc.nl.

Publikováno v: Nature communications [Nat Commun] 2022 Aug 04; Vol. 13 (1), pp. 4539. Date of Electronic Publication: 2022 Aug 04.