Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Bijesh George"'
Autor:
Bijesh George, Revikumar Amjesh, Aswathy Mary Paul, T. R. Santhoshkumar, Madhavan Radhakrishna Pillai, Rakesh Kumar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Although a defective vitamin D endocrine system has been widely suspected to be associated in SARS-CoV-2 pathobiology, the status of the vitamin D endocrine system and vitamin D-modulated genes in lung cells of patients infected with SARS-Co
Externí odkaz:
https://doaj.org/article/3114f67896354fdcb40d9447f1016a17
Autor:
Deivendran Sankaran, Revikumar Amjesh, Aswathy Mary Paul, Bijesh George, Rajat Kala, Sunil Saini, Rakesh Kumar
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 462 (2023)
Over the last three decades, p21-activated kinases (PAKs) have emerged as prominent intracellular nodular signaling molecules in cancer cells with a spectrum of cancer-promoting functions ranging from cell survival to anchorage-independent growth to
Externí odkaz:
https://doaj.org/article/d6a22b3a20e04272800b71e48c62aab9
Autor:
Aswathy Mary Paul, Revikumar Amjesh, Bijesh George, Deivendran Sankaran, Oleta A. Sandiford, Pranela Rameshwar, Madhavan Radhakrishna Pillai, Rakesh Kumar
Publikováno v:
Cells, Vol 11, Iss 23, p 3806 (2022)
Many human cancers, including breast cancer, are polygenic and involve the co-dysregulation of multiple regulatory molecules and pathways. Though the overexpression of genes and amplified chromosomal regions have been closely linked in breast cancer,
Externí odkaz:
https://doaj.org/article/cb3cfe86596f4c37b980591141f23c52
Autor:
Bijesh George, Bin Gui, Rajeswari Raguraman, Aswathy Mary Paul, Harikrishna Nakshatri, Madhavan Radhakrishna Pillai, Rakesh Kumar
Publikováno v:
Cells, Vol 11, Iss 15, p 2290 (2022)
Overexpression and hyperactivation of the serine/threonine protein kinase B (AKT) pathway is one of the most common cellular events in breast cancer progression. However, the nature of AKT1-specific genome-wide transcriptomic alterations in breast ca
Externí odkaz:
https://doaj.org/article/f83a6406e95a49388f6a3a2d737d73ec
Autor:
Aswathy Mary Paul, Bijesh George, Sunil Saini, Madhavan Radhakrishna Pillai, Masakazu Toi, Luis Costa, Rakesh Kumar
Publikováno v:
Cells, Vol 11, Iss 12, p 1927 (2022)
The prognosis of breast cancer (BC) in young women (BCYW) aged ≤40 years tends to be poorer than that in older patients due to aggressive phenotypes, late diagnosis, distinct biologic, and poorly understood genomic features of BCYW. Considering the
Externí odkaz:
https://doaj.org/article/94dbc456039746f9b81093ac1855578e
Autor:
Bijesh George, P. Mukundan Pillai, Aswathy Mary Paul, Revikumar Amjesh, Kim Leitzel, Suhail M. Ali, Oleta Sandiford, Allan Lipton, Pranela Rameshwar, Gabriel N. Hortobagyi, Madhavan Radhakrishna Pillai, Rakesh Kumar
Publikováno v:
Cells, Vol 10, Iss 2, p 433 (2021)
To define the growing significance of cellular targets and/or effectors of cancer drugs, we examined the fitness dependency of cellular targets and effectors of cancer drug targets across human cancer cells from 19 cancer types. We observed that the
Externí odkaz:
https://doaj.org/article/d6c4e6dac85a4706bdd630f119086ed9
Publikováno v:
Cancer and Metastasis Reviews. 39:583-601
Most epithelial cancer types are polygenic in nature and are driven by coordinated dysregulation of multiple regulatory pathways, genes, and protein modifications. The process of coordinated regulation of cancer promoting pathways in response to extr
Autor:
Oleta A. Sandiford, Bijesh George, Pranela Rameshwar, Suhail M. Ali, Kim Leitzel, Rakesh Kumar, Gabriel N. Hortobagyi, P. Mukundan Pillai, Revikumar Amjesh, Madhavan Radhakrishna Pillai, Allan Lipton, Aswathy Mary Paul
Publikováno v:
Cells
Volume 10
Issue 2
Cells, Vol 10, Iss 433, p 433 (2021)
Volume 10
Issue 2
Cells, Vol 10, Iss 433, p 433 (2021)
To define the growing significance of cellular targets of targeted cancer drugs, we examined the fitness dependency of cancer drug targets across human cancer cells in a CRISPR-Cas9 fitness screening dataset wherein cellular genes were selectively kn
Autor:
Ravikumar Amjesh, Rakesh Kumar, Bijesh George, Madhavan Radhakrishna Pillai, Aswathy Mary Paul
Although a defective vitamin D pathway has been widely suspected to be associated in SARS-CoV-2 pathobiology, the status of the vitamin D pathway and vitamin D-modulated genes in lung cells of patients infected with SARS-CoV-2 remains unknown. To und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b02a317df468651278f68c5a1d865e68
https://doi.org/10.1101/2020.12.21.423733
https://doi.org/10.1101/2020.12.21.423733
Publikováno v:
Cancer metastasis reviews. 39(3)
Most epithelial cancer types are polygenic in nature and are driven by coordinated dysregulation of multiple regulatory pathways, genes, and protein modifications. The process of coordinated regulation of cancer promoting pathways in response to extr