Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Autor: Wessel, J, Chu, AY, Willems, SM, Wang, S, Yaghootkar, H, Brody, JA, Dauriz, M, Hivert, MF, Raghavan, S, Lipovich, L, Hidalgo, B, Fox, K, Huffman, JE, An, P, Lu, Y, Rasmussen-Torvik, LJ, Grarup, N, Ehm, MG, Li, L, Baldridge, AS, Stančáková, A, Abrol, R, Besse, C, Boland, A, Bork-Jensen, J, Fornage, M, Freitag, DF, Garcia, ME, Guo, X, Hara, K, Isaacs, A, Jakobsdottir, J, Lange, LA, Layton, JC, Li, M, Hua Zhao, J, Meidtner, K, Morrison, AC, Nalls, MA, Peters, MJ, Sabater-Lleal, M, Schurmann, C, Silveira, A, Smith, AV, Southam, L, Stoiber, MH, Strawbridge, RJ, Taylor, KD, Varga, TV, Allin, KH, Amin, N, Aponte, JL, Aung, T, Barbieri, C, Bihlmeyer, NA, Boehnke, M, Bombieri, C, Bowden, DW, Burns, SM, Chen, Y, Chen, YD, Cheng, CY, Correa, A, Czajkowski, J, Dehghan, A, Ehret, GB, Eiriksdottir, G, Escher, SA, Farmaki, AE, Frånberg, M, Gambaro, G, Giulianini, F, Goddard, WA

Publikováno v: Wessel, J; Chu, AY; Willems, SM; Wang, S; Yaghootkar, H; Brody, JA; et al.(2015). Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nature Communications, 6. doi: 10.1038/ncomms6897. UCLA: Retrieved from: http://www.escholarship.org/uc/item/8rr9g67v

© 2015 Macmillan Publishers Limited. All rights reserved. Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e1e08b2b78e9f8ea0f2ec1d6cbe5b83e
http://www.escholarship.org/uc/item/8rr9g67v

Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization.

Autor: Willems SM; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; General Medicine Center, Saarland University Faculty of Medicine, Homburg, 66421, Germany., Ng NHJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore., Fernandez J; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Fine RS; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Current address: Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA, 02210, USA., Wheeler E; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Wessel J; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Departments of Epidemiology & Medicine, Schools of Public Health & Medicine, Indiana University, Indianapolis, IN, 46202, USA.; Diabetes Translational Research Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; General Medicine Division, Massachusetts General Hospital, Boston, MA, USA., Kitajima H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Marenne G; Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Sim X; Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, 117549, Singapore.; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Yaghootkar H; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Wang S; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Chen S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Chen Y; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands., Varga TV; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-205 02, Sweden., Asimit JL; Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.; MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, UK., Feng S; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Strawbridge RJ; Mental Health and Wellbeing, School of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8RZ, UK.; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, 171 76, Sweden., Kleinbrink EL; Quantitative Life Sciences, McGill University, Montreal, Quebec, Canada.; Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, 48201-1928, USA., Ahluwalia TS; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Gentofte, 2820, Denmark., An P; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, 63108, USA., Appel EV; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Arking DE; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Auvinen J; Center for Life Course Health Research, University of Oulu, Oulu, 90014, Finland.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Bihlmeyer NA; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Brody JA; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK., Chu AY; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA., Davies G; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Demirkan A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands., Floyd JS; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Gustafsson S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, 75237, Sweden., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Jakobsdottir J; Icelandic Heart Association, Kopavogur, Iceland., Järvelin MR; Center for Life Course Health Research, University of Oulu, Oulu, 90014, Finland.; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, W2 1PG, UK.; Biocenter Oulu, University of Oulu, Oulu, Finland., Jensen RA; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Keinanen-Kiukaanniemi S; Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland.; MRC and Unit of Primary Care, Oulu University Hospital, Oulu, Finland., Li M; Division of Nephrology, Internal Medicine, School of Medicine, University of Utah, Salt Lake City, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Lu Y; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA.; Department of Medicine, Division of Genetic Medicine, Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN, 37203, USA., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Manning AK; Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Marten J; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK., Meidtner K; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, 85764, Germany., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands., Muka T; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland., Pistis G; Italian National Research Council, Institute of Genetics and Biomedic Research, Cittadella Universitaria, Monserrato, 09042, Italy.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Prins B; Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Rice KM; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Sanna S; Italian National Research Council, Institute of Genetics and Biomedic Research, Cittadella Universitaria, Monserrato, 09042, Italy.; University Medical Center Groningen, Department of Genetics, University of Groningen, Groningen, 9700 RB, The Netherlands., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Southam L; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Tragante V; Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, 3584CX, The Netherlands., van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Barts Cardiovascular Research Unit, Barts and The London School of Medicine & Dentistry, Queen Mary University, London, EC1M 6BQ, UK., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Yiorkas AM; Section of Investigative Medicine, Department of Medicine, Imperial College London, London, W12 0NN, UK.; Department of Life Sciences, Brunel University London, London, UB8 3PH, UK., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Ealing Hospital, London North West Healthcare NHS Trust, Middlesex, UB1 3HW, UK., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Graff M; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA., Highland HM; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.; Human Genetics Center, The University of Texas School of Public Health; The University of Texas Graduate School of Biomedical Sciences at Houston;, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Justice AE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA., Marouli E; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Medina-Gomez C; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands., Afaq S; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, W2 1PG, UK., Alhejily WA; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Department of Medicine, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Amin N; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands., Asselbergs FW; Amsterdam University Medical Centers, Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands.; Health Data Research UK and Institute of Health Informatics, University College London, London, UK., Bonnycastle LL; Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD, 20892, USA., Bots ML; Center for Circulatory Health, University Medical Center Utrecht, Utrecht, 3508GA, The Netherlands., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital Vejle, Vejle, 7100, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, 5000, Denmark., Chen J; Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Danesh J; Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB18RN, UK., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands., Dehghan A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, W2 1PG, UK.; UK Dementia Research Institute, Imperial College London, London, UK., Ebeling T; Oulu University Hospital, Oulu, 90220, Finland., Elliott P; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, W2 1PG, UK.; Imperial College NIHR Biomedical Research Centre, London, UK.; Health Data Research UK, Imperial College London, London, UK., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece.; Department of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London, UK., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Franks PW; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-205 02, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA., Franks S; Institute of Reproductive and Developmental Biology, Imperial College London, London, W12 0NN, UK., Fritsche A; German Center for Diabetes Research (DZD), München-Neuherberg, 85764, Germany.; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, University Hospital of Tübingen, Tübingen, Germany., Gjesing AP; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Goodarzi MO; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Hallmans G; Department of Biobank Research, Umeå University, Umeå, SE-901 87, Sweden., Harris TB; Icelandic Heart Association, Kopavogur, Iceland., Herzig KH; Institute of Biomedicine and Biocenter of Oulu, Faculty of Medicine, Medical Research Center Oulu and Oulu University Hospital, Oulu, Finland.; Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, 60-572, Poland., Hivert MF; Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.; Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Jørgensen T; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, 2000, Denmark.; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.; Faculty of Medicine, University of Aalborg, Aalborg, 9100, Denmark., Jørgensen ME; Steno Diabetes Center Copenhagen, Gentofte, 2820, Denmark.; National Institute of Public Health, Southern Denmark University, Odense, 5000, Denmark., Jousilahti P; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland., Kajantie E; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland.; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Karaleftheri M; Echinos Medical Centre, Echinos, Greece., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Kinnunen L; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland., Koistinen HA; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland.; University of Helsinki and Department of Medicine, Helsinki University Hospital, Helsinki, FI-00029, Finland.; Minerva Foundation Institute for Medical Research, Biomedicum 2U Helsinki, Helsinki, FI-00290, Finland., Komulainen P; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland., Kovacs P; Integrated Research and Treatment (IFB) Center Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany.; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, 04103, Germany., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, Finland., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, Finland., Lange LA; Department of Medicine, Division of Bioinformatics and Personalized Medicine, University of Colorado Denver, Denver, CO, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA., Leong A; Division of General Internal Medicine, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA., Lindström J; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland., Manning Fox JE; Alberta Diabetes Institute IsletCore, University of Alberta, Edmonton, T6G 2E1, Canada.; Department of Pharmacology, University of Alberta, Edmonton, T6G 2E1, Canada., Männistö S; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland., Maruthur NM; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.; Department of Medicine, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA., Moilanen L; Kuopio University Hospital, Kuopio, 70210, Finland., Mulas A; Italian National Research Council, Institute of Genetics and Biomedic Research, Cittadella Universitaria, Monserrato, 09042, Italy.; Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, 07100, Italy., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, 20892, USA.; Data Tecnica International LLC, Glen Echo, MD, 20812, USA., Neville M; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA., Pattie A; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Petersen ERB; Department of Clinical Biochemistry, Lillebaelt Hospital Vejle, Vejle, 7100, Denmark., Puolijoki H; South Ostobothnia Central Hospital, Seinajoki, 60220, Finland., Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan., Redmond P; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Renström F; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-205 02, Sweden.; Department of Biobank Research, Umeå University, Umeå, SE-901 87, Sweden., Roden M; German Center for Diabetes Research (DZD), München-Neuherberg, 85764, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany., Saleheen D; Center for Non-Communicable Diseases, Karachi, Pakistan.; Department of Biostatistics and Epidemiology, University of Pennsylvania, 19104, USA., Saltevo J; Central Finland Central Hospital, Jyvaskyla, 40620, Finland., Savonen K; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, 70029, Finland., Sebert S; Biocenter Oulu, University of Oulu, Oulu, Finland.; Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland., Skaaby T; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, 2000, Denmark., Small KS; Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK., Stančáková A; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, Finland., Stokholm J; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Strauch K; Institute of Genetic Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Tai ES; Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, 117549, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; Duke-NUS Medical School, Singapore, 169857, Singapore., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Thuesen BH; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, 2000, Denmark., Tönjes A; Department of Medicine, University of Leipzig, Leipzig, 04103, Germany., Tsafantakis E; Anogia Medical Centre, Anogia, Greece., Tuomi T; Folkhälsan Research Centre, Helsinki, Finland.; Department of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland.; Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Tuomilehto J; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Uusitupa M; Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70210, Finland., Vääräsmäki M; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Welfare, Children, Adolescents and Families Unit, National Institute for Health and Welfare, Oulu, Finland., Vaartjes I; Center for Circulatory Health, University Medical Center Utrecht, Utrecht, 3508GA, The Netherlands., Zoledziewska M; Italian National Research Council, Institute of Genetics and Biomedic Research, Cittadella Universitaria, Monserrato, 09042, Italy., Abecasis G; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Balkau B; INSERM U1018, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Villejuif, France., Bisgaard H; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Blakemore AI; Section of Investigative Medicine, Department of Medicine, Imperial College London, London, W12 0NN, UK.; Department of Life Sciences, Brunel University London, London, UB8 3PH, UK., Blüher M; Department of Medicine, University of Leipzig, Leipzig, 04103, Germany.; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Boeing H; Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, 14558, Germany., Boerwinkle E; The Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, 77030, USA., Bønnelykke K; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA., Caulfield MJ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Barts Cardiovascular Research Unit, Barts and The London School of Medicine & Dentistry, Queen Mary University, London, EC1M 6BQ, UK., Chambers JC; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, W2 1PG, UK.; Ealing Hospital, London North West Healthcare NHS Trust, Middlesex, UB1 3HW, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.; Harvard School of Medicine, Boston, MA, USA.; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Collins FS; Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD, 20892, USA., Coresh J; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA., Cucca F; Italian National Research Council, Institute of Genetics and Biomedic Research, Cittadella Universitaria, Monserrato, 09042, Italy.; Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, 07100, Italy., de Borst GJ; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., den Ruijter HM; Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA., Ferrannini E; CNR Institute of Clinical Physiology, Department of Clinical & Experimental Medicine, University of Pisa, Pisa, Italy., Franco OH; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland., Grallert H; German Center for Diabetes Research (DZD), München-Neuherberg, 85764, Germany.; Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Munich, Germany., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense, 5000, Denmark., Hattersley AT; University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK., Hirschhorn JN; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Departments of Pediatrics and Genetics, Harvard Medical School, Boston, MA, 02115, USA., Ikram A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands., Ingelsson E; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, 94305, USA.; Stanford Diabetes Research Center, Stanford University, Stanford, 94305, USA., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LE, UK., Kaw KT; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, CB1 8RN, UK., Kiess W; Pediatric Research Center, Department of Women & Child Health, University of Leipzig, Leipzig, Germany., Kooner JS; Ealing Hospital, London North West Healthcare NHS Trust, Middlesex, UB1 3HW, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK.; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK., Körner A; Pediatric Research Center, Department of Women & Child Health, University of Leipzig, Leipzig, Germany., Lakka T; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, 70029, Finland.; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, 70211, Finland., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Lind L; Department of Medical Sciences, Molecular Epidemiology; EpiHealth, Uppsala University, Uppsala, 75185, Sweden., Lindgren CM; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; The Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, OX3 7BN, UK., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, 2000, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Lipovich L; Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, 48201-1928, USA.; Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Liu J; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands., Liu Y; Department of Epidemiology & Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, NC, 27157, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA.; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA., MacDonald PE; Alberta Diabetes Institute IsletCore, University of Alberta, Edmonton, T6G 2E1, Canada.; Department of Pharmacology, University of Alberta, Edmonton, T6G 2E1, Canada., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA., Morris AD; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH16 4UX, UK., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Barts Cardiovascular Research Unit, Barts and The London School of Medicine & Dentistry, Queen Mary University, London, EC1M 6BQ, UK., Murray A; Aberdeen Biomedical Imaging Centre, University of Aberdeen, Foresterhill Health Campus, Aberdeen, AB25 2ZD, UK., Padmanabhan S; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK., Palmer CNA; Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, DD2 4BF, UK., Pasterkamp G; Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands.; Laboratory of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Porteous D; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK., Province MA; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, 63108, USA., Psaty BM; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.; Departments of Epidemiology, Health Systems and Population Health, University of Washington, Seattle, Seattle, WA, USA., Rauramaa R; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.; Harvard School of Medicine, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Rolandsson O; Department of Public Health & Clinical Medicine, Section for Family Medicine, Umeå University, Umeå, SE-901 85, Sweden., Rorsman P; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LE, UK., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands., Rudan I; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH16 4UX, UK., Salomaa V; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, 85764, Germany., Sladek R; Department of Medicine, McGill University, Montreal, Quebec, H4A 3J1, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, H3A 1B1, Canada., Smith BH; Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, DD2 4BF, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Stumvoll M; Department of Medicine, University of Leipzig, Leipzig, 04103, Germany., van Duijn CM; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands., Walker M; Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle, NE2 4HH, UK., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Zeggini E; Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Technical University of Munich (TUM) and Klinikum Rechts der Isar, TUM School of Medicine, Munich, Germany., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Morris AP; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Florez JC; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA., McCarthy MI; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LE, UK.; Current address: Genentech, South San Francisco, CA, 94080, USA., Meigs JB; Division of General Internal Medicine, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA.; Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Current address: Genentech, South San Francisco, CA, 94080, USA., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Gloyn AL; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LE, UK.; Division of Endocrinology, Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA., Barroso I; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; Department of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.; Exeter Centre of Excellence in Diabetes (EXCEED), University of Exeter Medical School, Exeter, UK.

Publikováno v: Wellcome open research [Wellcome Open Res] 2023 Oct 20; Vol. 8, pp. 483. Date of Electronic Publication: 2023 Oct 20 (Print Publication: 2023).

Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions.

Autor: Bihlmeyer NA; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America., Kwee LC; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America., Clish CB; Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America., Deik AA; Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America., Gerszten RE; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America., Pagidipati NJ; Duke Clinical Research Institute, Duke University, Durham, North Carolina, United States of America.; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America., Laferrère B; Columbia University Irving Medical Center, New York, New York, United States of America., Svetkey LP; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America., Newgard CB; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America., Kraus WE; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America., Shah SH; Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, United States of America.; Duke Clinical Research Institute, Duke University, Durham, North Carolina, United States of America.; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America.

Publikováno v: PloS one [PLoS One] 2021 May 27; Vol. 16 (5), pp. e0240764. Date of Electronic Publication: 2021 May 27 (Print Publication: 2021).

The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights.

Autor: McCann JR; Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA., Bihlmeyer NA; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina, USA., Roche K; Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA., Catherine C; Department of Pediatrics, Duke University, Durham, North Carolina, USA., Jawahar J; Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA., Kwee LC; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina, USA., Younge NE; Department of Pediatrics, Duke University, Durham, North Carolina, USA., Silverman J; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina, USA., Ilkayeva O; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina, USA., Sarria C; Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA., Zizzi A; Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA., Wootton J; Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA., Poppe L; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina, USA., Anderson P; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina, USA., Arlotto M; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina, USA., Wei Z; Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA., Granek JA; Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.; Duke Microbiome Center, Duke University Durham, North Carolina, USA., Valdivia RH; Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.; Duke Microbiome Center, Duke University Durham, North Carolina, USA., David LA; Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.; Duke Microbiome Center, Duke University Durham, North Carolina, USA., Dressman HK; Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.; Duke Microbiome Center, Duke University Durham, North Carolina, USA., Newgard CB; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina, USA., Shah SH; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA., Seed PC; Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Stanley Manne Children's Research Institute, Northwestern University Medical Center, Chicago, Illinois, USA., Rawls JF; Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.; Duke Microbiome Center, Duke University Durham, North Carolina, USA., Armstrong SC; Department of Pediatrics, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA.

Publikováno v: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2021 Mar; Vol. 29 (3), pp. 569-578.

Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation.

Autor: Weng LC; Cardiovascular Research Center (L.-C.W., A.W.H., P.L.H., P.T.E.), MGH, Boston.; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA (L.-C.W., A.W.H., S.H.C., S.J.J., P.T.E., S.A.L.)., Hall AW; Cardiovascular Research Center (L.-C.W., A.W.H., P.L.H., P.T.E.), MGH, Boston.; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA (L.-C.W., A.W.H., S.H.C., S.J.J., P.T.E., S.A.L.)., Choi SH; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA (L.-C.W., A.W.H., S.H.C., S.J.J., P.T.E., S.A.L.)., Jurgens SJ; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA (L.-C.W., A.W.H., S.H.C., S.J.J., P.T.E., S.A.L.)., Haessler J; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA (J.H., C.K.)., Bihlmeyer NA; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (N.A.B., D.E.A.)., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research (N.G., T.H.), Faculty of Health & Medicine Sciences, University of Copenhagen, Denmark., Lin H; Boston University & NHLBI's Framingham Heart Study, Framingham, MA (H.L., J.K., E.J.B., K.L.L.).; Section of Computational Biomedicine, Department of Medicine (H.L.), Boston University School of Medicine, Boston, MA., Teumer A; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Germany (A.T., U.V., M.D., S.B.F.).; Institute for Community Medicine (A.T.), University Medicine Greifswald, Germany., Li-Gao R; Department of Clinical Epidemiology (R.L.-G., D.O.M.-K.), Leiden University Medical Center, the Netherlands., Yao J; The Institute for Translational Genomics & Population Sciences at Harbor-UCLA Medical Center, Torrance, CA (J.Y., X.G., K.D.T., H.J.L., J.I.R.)., Guo X; The Institute for Translational Genomics & Population Sciences at Harbor-UCLA Medical Center, Torrance, CA (J.Y., X.G., K.D.T., H.J.L., J.I.R.).; Department of Pediatrics (X.G., K.D.T., H.J.L.), David Geffen School of Medicine at UCLA, Los Angeles, CA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine (J.A.B., N.S.), University of Washington., Müller-Nurasyid M; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Germany (M.M.-N., K.S.).; Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Germany (M.M.-N., K.S., M.F.S., S.K.).; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany (M.M.-N., K.S.)., Schramm K; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Germany (M.M.-N., K.S.).; Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Germany (M.M.-N., K.S., M.F.S., S.K.).; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany (M.M.-N., K.S.)., Verweij N; Genomics plc, Oxford, United Kingdom (N.V.).; Department of Cardiology (N.V., R.A.d.B., P.v.d.M., P.v.d.H.), University of Groningen & University Medical Center., van den Berg ME; Department of Epidemiology (M.E.v.d.B.)., van Setten J; Erasmus MC, Medical Center Rotterdam, Division of Heart & Lungs, Department of Cardiology, University of Utrecht, University Medical Center Utrecht (J.v.S., F.W.A.)., Isaacs A; CARIM School for Cardiovascular Diseases (A.I.), Maastricht University, the Netherlands.; Department of Physiology (A.I.), Maastricht University, the Netherlands., Ramírez J; National Institute for Health Research, Barts Cardiovascular Biomedical Research Center (J.R., H.R.W., P.B.M.), Queen Mary University of London, London.; William Harvey Research Institute, Barts & The London School of Medicine & Dentistry (J.R., H.R.W., P.B.M.), Queen Mary University of London, London., Warren HR; National Institute for Health Research, Barts Cardiovascular Biomedical Research Center (J.R., H.R.W., P.B.M.), Queen Mary University of London, London.; William Harvey Research Institute, Barts & The London School of Medicine & Dentistry (J.R., H.R.W., P.B.M.), Queen Mary University of London, London., Padmanabhan S; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, United Kingdom (S.P.)., Kors JA; Department of Medicine Informatics (J.A.K.), Erasmus University Medical Center, Rotterdam, the Netherlands., de Boer RA; Department of Cardiology (N.V., R.A.d.B., P.v.d.M., P.v.d.H.), University of Groningen & University Medical Center., van der Meer P; Department of Cardiology (N.V., R.A.d.B., P.v.d.M., P.v.d.H.), University of Groningen & University Medical Center., Sinner MF; Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Germany (M.M.-N., K.S., M.F.S., S.K.).; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance (M.F.S., M.W., S.K., A.P.)., Waldenberger M; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance (M.F.S., M.W., S.K., A.P.).; Institute of Epidemiology (M.W., A.P.), Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology (M.W.), Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology & Health Services (B.M.P.), University of Washington.; Kaiser Permanente Washington Health Research Institute, Seattle, WA (B.M.P.)., Taylor KD; The Institute for Translational Genomics & Population Sciences at Harbor-UCLA Medical Center, Torrance, CA (J.Y., X.G., K.D.T., H.J.L., J.I.R.).; Department of Pediatrics (X.G., K.D.T., H.J.L.), David Geffen School of Medicine at UCLA, Los Angeles, CA., Völker U; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Germany (A.T., U.V., M.D., S.B.F.).; Interfaculty Institute for Genetics & Functional Genomics (U.V.), University Medicine Greifswald, Germany., Kanters JK; Lab of Experimental Cardiology (J.K.K.), Faculty of Health & Medicine Sciences, University of Copenhagen, Denmark., Li M; Division of Nephrology & Hypertension, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT (M.L.)., Alonso A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (A.A.)., Perez MV; Department of Medicine, Stanford University, Palo Alto, CA (M.V.P.)., Vaartjes I; Julius Center for Health Sciences & Primary Care, University Medical Center Utrecht, Utrecht University, the Netherlands (I.V., M.L.B.)., Bots ML; Julius Center for Health Sciences & Primary Care, University Medical Center Utrecht, Utrecht University, the Netherlands (I.V., M.L.B.)., Huang PL; Cardiovascular Research Center (L.-C.W., A.W.H., P.L.H., P.T.E.), MGH, Boston., Heckbert SR; Cardiovascular Health Research Unit, Department of Epidemiology (S.R.H.), University of Washington., Lin HJ; The Institute for Translational Genomics & Population Sciences at Harbor-UCLA Medical Center, Torrance, CA (J.Y., X.G., K.D.T., H.J.L., J.I.R.).; Department of Pediatrics (X.G., K.D.T., H.J.L.), David Geffen School of Medicine at UCLA, Los Angeles, CA., Kornej J; Boston University & NHLBI's Framingham Heart Study, Framingham, MA (H.L., J.K., E.J.B., K.L.L.)., Munroe PB; National Institute for Health Research, Barts Cardiovascular Biomedical Research Center (J.R., H.R.W., P.B.M.), Queen Mary University of London, London.; William Harvey Research Institute, Barts & The London School of Medicine & Dentistry (J.R., H.R.W., P.B.M.), Queen Mary University of London, London., van Duijn CM; Department of Epidemiology (C.M.v.D.), Erasmus University Medical Center, Rotterdam, the Netherlands.; Nuffield Department of Population Health, Medical Sciences Division, St. Cross College, Oxford University (C.M.v.D.)., Asselbergs FW; Erasmus MC, Medical Center Rotterdam, Division of Heart & Lungs, Department of Cardiology, University of Utrecht, University Medical Center Utrecht (J.v.S., F.W.A.).; Health Data Research UK & Institute of Health Informatics (F.W.A.), University College London, United Kingdom.; Institute of Cardiovascular Science, Faculty of Population Health Sciences (F.W.A.), University College London, United Kingdom., Stricker BH; Department of Internal Medicine (B.H.S.).; Department of Medicine Informatics (B.H.S.).; Inspectorate of Health Care (B.H.S.), ICIN-Netherlands Heart Institute, Utrecht., van der Harst P; Department of Cardiology (N.V., R.A.d.B., P.v.d.M., P.v.d.H.), University of Groningen & University Medical Center.; Department of Genetics (P.v.d.H.), University of Groningen & University Medical Center.; Durrer Center for Cardiogenetic Research (P.v.d.H.), ICIN-Netherlands Heart Institute, Utrecht., Kääb S; Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Germany (M.M.-N., K.S., M.F.S., S.K.).; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance (M.F.S., M.W., S.K., A.P.)., Peters A; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance (M.F.S., M.W., S.K., A.P.).; Institute of Epidemiology (M.W., A.P.), Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research, Neuherberg, Germany (A.P.)., Sotoodehnia N; Cardiovascular Health Research Unit, Department of Medicine (J.A.B., N.S.), University of Washington., Rotter JI; The Institute for Translational Genomics & Population Sciences at Harbor-UCLA Medical Center, Torrance, CA (J.Y., X.G., K.D.T., H.J.L., J.I.R.).; Departments of Pediatrics & Human Genetics (J.I.R.), David Geffen School of Medicine at UCLA, Los Angeles, CA., Mook-Kanamori DO; Department of Clinical Epidemiology (R.L.-G., D.O.M.-K.), Leiden University Medical Center, the Netherlands.; Department of Public Health & Primary Care (D.O.M.-K.), Leiden University Medical Center, the Netherlands., Dörr M; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Germany (A.T., U.V., M.D., S.B.F.).; Department of Internal Medicine B (M.D., S.B.F.), University Medicine Greifswald, Germany., Felix SB; 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Publikováno v: Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2020 Oct; Vol. 13 (5), pp. 387-395. Date of Electronic Publication: 2020 Aug 21.