Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Bifunctional Antibodies"'
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 13, Iss 4, Pp 836-842 (2017)
Bispecific antibody engineering, in which binding specificities toward 2 distinct epitopes are combined into a single molecule, can greatly enhance immunotherapeutic properties of monoclonal antibodies. While the bispecific antibody approach has been
Externí odkaz:
https://doaj.org/article/6d1a6519050143a18a3f28a0b61de2fe
Publikováno v:
Therapeutic Advances in Hematology
Therapeutic Advances in Hematology, Vol 12 (2021)
Therapeutic Advances in Hematology, Vol 12 (2021)
Outcomes of patients with multiple myeloma (MM) who become refractory to standard therapies are particularly poor and novel agents are greatly needed to improve outcomes in such patients. B-cell maturation antigen (BCMA) has become an important thera
Akademický článek
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Autor:
K. Kis-Toth, K. L. Otipoby, J. Viney, N. Higginson-Scott, I. Mascanfroni, M. Cianci, M. Rowe, A. Boisvert, M. Borah, Purvi Mande, P. Halvey, A. Agrawal, S. Borthakur, D. Rios
Publikováno v:
Journal of Investigative Dermatology. 141:B18
Publikováno v:
Bulletin of Experimental Biology and Medicine. 116:1140-1142
Akademický článek
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Autor:
Binodh S. DeSilva, George S. Wilson
Publikováno v:
Methods (San Diego, Calif.). 22(1)
The synthesis of bifunctional antibodies using the principle of solid-phase synthesis is described. Two Fab′ fragments were chemically linked together via a bismaleimide crosslinking reagent. The F(ab′) 2 fragments from intact immunoglobulin G (I
Autor:
Binodh S. Desilva, George S. Wilson
Publikováno v:
Journal of immunological methods. 188(1)
Bifunctional antibodies were prepared using the principle of solid-phase synthesis. The two Fab′ fragments were chemically linked together via a bismaleimide crosslinking reagent. The F(ab′)2 fragments from intact IgG were prepared using an immob
Publikováno v:
Journal of immunological methods. 187(1)
A simple non-selective methodology was developed and standardized to generate desired hybrid-hybridoma or quadroma secreting bifunctional antibodies. This novel protocol is based on microelectrofusion on a meander chamber using a few hundred cells of