Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Autor: Nolte, IM, Munoz, ML, Tragante, V, Amare, AT, Jansen, R, Vaez, A, Von Der Heyde, B, Avery, CL, Bis, JC, Dierckx, B, Van Dongen, J, Gogarten, SM, Goyette, P, Hernesniemi, J, Huikari, V, Hwang, SJ, Jaju, D, Kerr, KF, Kluttig, A, Krijthe, BP, Kumar, J, Van Der Laan, SW, Lyytikäinen, LP, Maihofer, AX, Minassian, A, Van Der Most, PJ, Müller-Nurasyid, M, Nivard, M, Salvi, E, Stewart, JD, Thayer, JF, Verweij, N, Wong, A, Zabaneh, D, Zafarmand, MH, Abdellaoui, A, Albarwani, S, Albert, C, Alonso, A, Ashar, F, Auvinen, J, Axelsson, T, Baker, DG, De Bakker, PIW, Barcella, M, Bayoumi, R, Bieringa, RJ, Boomsma, D, Boucher, G, Britton, AR, Christophersen, IE, Dietrich, A, Ehret, GB, Ellinor, PT, Eskola, M, Felix, JF, Floras, JS, Franco, OH, Friberg, P, Gademan, MGJ, Geyer, MA, Giedraitis, V, Hartman, CA, Hemerich, D, Hofman, A, Hottenga, JJ, Huikuri, H, Hutri-Kähönen, N, Jouven, X

Publikováno v: Nolte, IM; Munoz, ML; Tragante, V; Amare, AT; Jansen, R; Vaez, A; et al.(2017). Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nature Communications, 8. doi: 10.1038/ncomms15805. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0xj2x119

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 indiv

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http://www.escholarship.org/uc/item/0xj2x119

Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

Autor: Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands., Munoz ML; Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands., Tragante V; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584CX, The Netherlands., Amare AT; Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.; Department of Epidemiology, School of Medicine, University of Adelaide, Adelaide, South Australia 5005, Australia.; College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar 6000, Ethiopia., Jansen R; Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 BT, The Netherlands., Vaez A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.; School of Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran., von der Heyde B; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75237, Sweden.; Science for Life Laboratory, Uppsala University, Uppsala 75237, Sweden., Avery CL; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98104, USA., Dierckx B; Department of Child and Adolescent Psychiatry/Psychology, Department of Child and Adolescent Psychiatry, PO Box 2060, Rotterdam 3000 CB, The Netherlands.; The Generation R Study Group, Erasmus MC, PO Box 2060, Rotterdam 3000 CB, The Netherlands., van Dongen J; Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands., Gogarten SM; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA., Goyette P; Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8., Hernesniemi J; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland.; Department of Cardiology, Heart Hospital, Tampere University Hospital, Tampere 33521, Finland., Huikari V; Center for Life Course Health Research, University of Oulu, Oulu 90014, Finland., Hwang SJ; Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Population Sciences Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA., Jaju D; Department of Clinical Physiology, Sultan Qaboos University Hospital, Muscat-Al Khoudh 123, Sultanate of Oman., Kerr KF; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA., Kluttig A; Institute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale) 06097, Germany., Krijthe BP; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands., Kumar J; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75237, Sweden.; Science for Life Laboratory, Uppsala University, Uppsala 75237, Sweden., van der Laan SW; Laboratory of Experimental Cardiology, Department of Heart and Lung, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland., Maihofer AX; Department of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.; Center for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, California 92161, USA., Minassian A; Department of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.; Center for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, California 92161, USA., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.; Department of Medicine, University Hospital Munich, Ludwig-Maximilians-University, Munich 80539, Germany.; DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich 80336, Germany., Nivard M; Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.; EMGO+ Institute for Health and Care Research, VU University &VU University Medical Center, Amsterdam 1081 HV, The Netherlands., Salvi E; Department of Health Sciences, University of Milano, Milano 20122, Italy., Stewart JD; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Thayer JF; Department of Psychology, The Ohio State University, 1835 Neil Avenue, Columbus, Ohio 43210, USA., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands., Wong A; MRC Unit for Lifelong Health and Ageing, University College London, 33 Bedford Place, London WC1B 5JU, UK., Zabaneh D; Institute of Psychiatry, Psychology &Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK.; University College London Genetics Institute, University College London, London WC1E 6BT, UK., Zafarmand MH; Department of Public Health, Academic Medical Center (AMC), University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.; Department of Obstetrics and Gynaecology, Academic Medical Centre, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands., Abdellaoui A; Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.; EMGO+ Institute for Health and Care Research, VU University &VU University Medical Center, Amsterdam 1081 HV, The Netherlands., Albarwani S; Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat Al-Khoudh 123, Sultanate of Oman., Albert C; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Alonso A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA., Ashar F; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Auvinen J; Center for Life Course Health Research, University of Oulu, Oulu 90014, Finland.; Unit of Primary Health Care, Oulu University Hospital, Oulu 90220, Finland., Axelsson T; Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75237, Sweden., Baker DG; Center for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, California 92161, USA.; Department of Psychiatry, University of California, San Diego, San Diego, California 92093, USA., de Bakker PIW; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Barcella M; Department of Health Sciences, University of Milano, Milano 20122, Italy., Bayoumi R; College of Medicine, Mohammed Bin Rashid University, PO Box 505055, Dubai Healthcare City, United Arab Emirates., Bieringa RJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands., Boomsma D; Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.; EMGO+ Institute for Health and Care Research, VU University &VU University Medical Center, Amsterdam 1081 HV, The Netherlands., Boucher G; Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8., Britton AR; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK., Christophersen I; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02114, USA.; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Rud 1346, Norway., Dietrich A; Department of Child- and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands., Ehret GB; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland., Ellinor PT; Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02114, USA.; Cardiac Arrhythmia Service &Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA., Eskola M; Department of Cardiology, Heart Hospital, Tampere University Hospital, Tampere 33521, Finland.; Department of Cardiology, University of Tampere School of Medicine, Tampere 33014, Finland., Felix JF; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands., Floras JS; University Health Network and Mount Sinai Hospital Division of Cardiology, Department of Medicine, University of Toronto, Ontario, Canada M5S.; Toronto General Research Institute, University Health Network, Toronto, Canada., Franco OH; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands., Friberg P; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden., Gademan MGJ; Department of Public Health, Academic Medical Center (AMC), University of Amsterdam, Amsterdam 1105 AZ, The Netherlands., Geyer MA; Department of Psychiatry, University of California, San Diego, San Diego, California 92093, USA., Giedraitis V; Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala 75237, Sweden., Hartman CA; Interdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands., Hemerich D; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584CX, The Netherlands.; CAPES Foundation, Ministry of Education of Brazil, Brasília DF 70040-020, Brazil., Hofman A; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands., Hottenga JJ; Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.; EMGO+ Institute for Health and Care Research, VU University &VU University Medical Center, Amsterdam 1081 HV, The Netherlands., Huikuri H; Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu 90220, Finland., Hutri-Kähönen N; Department of Pediatrics, Tampere University Hospital, Tampere 33521, Finland.; Department of Pediatrics, University of Tampere School of Medicine, Tampere 33014, Finland., Jouven X; INSERM U970, Paris Descartes University, Paris 75006, France., Junttila J; Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu 90220, Finland., Juonala M; Department of Medicine, University of Turku, Turku 20520, Finland.; Division of Medicine, Turku University Hospital, Turku 20521, Finland., Kiviniemi AM; Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu 90220, Finland., Kors JA; Department of Medical Informatics, Erasmus Medical Center, Rotterdam 3015 CE, The Netherlands., Kumari M; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.; ISER, Essex University, Colchester, Essex CO4 3SQ, UK., Kuznetsova T; Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven 3000, Belgium., Laurie CC; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA., Lefrandt JD; Department of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands., Li Y; Division of Genetic Epidemiology, Institute for Medical Biometry and Statistics, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79110, Germany., Li Y; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.; Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.; Department of Computer Science, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Liao D; Division of Epidemiology, Department of Public Health Sciences, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA., Limacher MC; Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32611, USA., Lin HJ; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.; Division of Medical Genetics, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California 90502, USA., Lindgren CM; Li Ka Shing Centre for Health Information and Discovery, The Big Data Institute, University of Oxford, Oxford OX3 7BN, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Lubitz SA; Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02114, USA.; Cardiac Arrhythmia Service &Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., McKnight B; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98104, USA.; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Zu Schwabedissen HM; Biopharmacy, Department Pharmaceutical Sciences, University of Basel, Basel CH-4056, Switzerland., Milaneschi Y; Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 BT, The Netherlands., Mononen N; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland., Morris AP; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA., Navis G; Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands., Neijts M; Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.; EMGO+ Institute for Health and Care Research, VU University &VU University Medical Center, Amsterdam 1081 HV, The Netherlands., Nikus K; Department of Cardiology, Heart Hospital, Tampere University Hospital, Tampere 33521, Finland.; Department of Cardiology, University of Tampere, School of Medicine, Tampere 33014, Finland., North KE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.; Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599, USA., O'Connor DT; Department of Medicine, University of California, San Diego, San Diego, California 92093, USA., Ormel J; Interdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands., Perz S; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany., Peters A; DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich 80336, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.; German Center for Diabetes Research, Neuherberg 85764, Germany., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98104, USA.; Departments of Epidemiology and Health Services, University of Washington, Seattle, Washington 98195, USA.; Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland., Risbrough VB; Department of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.; Center for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, California 92161, USA., Sinner MF; Department of Medicine, University Hospital Munich, Ludwig-Maximilians-University, Munich 80539, Germany.; DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich 80336, Germany., Siscovick D; The New York Academy of Medicine, New York, New York 10029, USA., Smit JH; Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 BT, The Netherlands., Smith NL; Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA.; Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington 98195, USA.; Seattle Epidemiologic Research and Information Center, Veterans Affairs Office of Research and Development, Seattle, Washington 98108, USA., Soliman EZ; Epidemiological Cardiology Research Center (EPICARE), Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Sotoodehnia N; Cardiovascular Health Research Unit, Division of Cardiology, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington 98101, USA., Staessen JA; Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven 3000, Belgium., Stein PK; Heart Rate Variability Lab, Washington University School of Medicine, St Louis, Missouri 63108, USA., Stilp AM; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA., Stolarz-Skrzypek K; First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Cracow 31-008, Poland., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich 81377, Germany., Sundström J; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 751 85, Sweden., Swenne CA; Department of Cardiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Syvänen AC; Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75237, Sweden., Tardif JC; Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8.; Université de Montréal, Montreal, Quebec, Canada H3T IJ4., Taylor KD; Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90509, USA., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany., Thornton TA; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA., Tinker LE; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Uitterlinden AG; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam 3015 CE, The Netherlands.; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging NCHA), Leiden 2300 RC, The Netherlands., van Setten J; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584CX, The Netherlands., Voss A; Institute of Innovative Health Technologies-IGHT Jena Ernst-Abbe-Hochschule Jena, Jena 07745, Germany., Waldenberger M; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany., Wilhelmsen KC; Departments of Genetics and Neurology University of North Carolina, Chapel Hill, North Carolina 27599, USA.; The Renaissance Computing Institute, Chapel Hill, North Carolina 27599, USA., Willemsen G; Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.; EMGO+ Institute for Health and Care Research, VU University &VU University Medical Center, Amsterdam 1081 HV, The Netherlands., Wong Q; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA., Zhang ZM; Epidemiological Cardiology Research Center (EPICARE), Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.; Department of Epidemiology &Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA., Cusi D; Institute of Biomedical Technologies, CNR-Italian National Research Council, Milan 20090, Italy.; KOS Genetic SRL, Bresso (Milano) 20091, Italy., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA., Greiser HK; German Cancer Research Centre, Division of Cancer Epidemiology, Heidelberg 69210, Germany., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands., Hassan M; Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat Al-Khoudh 123, Sultanate of Oman., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75237, Sweden.; Science for Life Laboratory, Uppsala University, Uppsala 75237, Sweden.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA., Järvelin MR; Center for Life Course Health Research, University of Oulu, Oulu 90014, Finland.; Unit of Primary Health Care, Oulu University Hospital, Oulu 90220, Finland.; Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, St Mary's campus, Imperial College London, London W2 1PG, UK.; Biocenter Oulu University of Oulu, Oulu 90014, Finland., Kääb S; Department of Medicine, University Hospital Munich, Ludwig-Maximilians-University, Munich 80539, Germany.; DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich 80336, Germany., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland.; Department of Clinical Physiology, University of Tampere, School of Medicine, Tampere 33014, Finland., Kivimaki M; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK., Kooperberg C; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Kuh D; MRC Unit for Lifelong Health and Ageing, University College London, 33 Bedford Place, London WC1B 5JU, UK., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland., Lind L; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 751 85, Sweden., Nievergelt CM; Department of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.; Center for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, California 92161, USA., O'Donnell CJ; Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Population Sciences Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA.; Cardiology Section, Boston Veteran's Administration Healthcare, Boston, Maryland 02132, USA., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands., Penninx B; Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 BT, The Netherlands., Reiner AP; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.; Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington 98195, USA., Riese H; Interdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands., van Roon AM; Department of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands., Rioux JD; Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8.; Université de Montréal, Montreal, Quebec, Canada H3T IJ4., Rotter JI; Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90509, USA., Sofer T; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA., Stricker BH; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands.; Inspectorate for Health Care, The Hague 2511 VX, The Netherlands., Tiemeier H; Department of Child and Adolescent Psychiatry/Psychology, Department of Child and Adolescent Psychiatry, PO Box 2060, Rotterdam 3000 CB, The Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands., Vrijkotte TGM; Department of Public Health, Academic Medical Center (AMC), University of Amsterdam, Amsterdam 1105 AZ, The Netherlands., Asselbergs FW; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584CX, The Netherlands.; Institute of Cardiovascular Science, University College London, 222 Euston Road, London NW1 2DA, UK.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht 3501 DG, The Netherlands., Brundel BJJM; Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, De Boelelaan 1118, Amsterdam 1081 HV, The Netherlands., Heckbert SR; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98104, USA.; Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington 98195, USA., Whitsel EA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.; Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA., den Hoed M; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75237, Sweden.; Science for Life Laboratory, Uppsala University, Uppsala 75237, Sweden., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands., de Geus EJC; Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.; EMGO+ Institute for Health and Care Research, VU University &VU University Medical Center, Amsterdam 1081 HV, The Netherlands.

Publikováno v: Nature communications [Nat Commun] 2017 Jun 14; Vol. 8, pp. 15805. Date of Electronic Publication: 2017 Jun 14.