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A putative role of p53 pathway against impulse noise induced damage as demonstrated by protection with pifithrin-alpha and a Src inhibitor

Autor: Thomas M. Nicotera, Eric C. Bielefeld, Donald Henderson, Anna Rita Fetoni, Gaetano Paludetti

Publikováno v: Neuroscience research.

Exposure to high-level noise leads to oxidative stress and triggers apoptosis of the hair cells. This study examined whether p53, a tumor suppressor protein, is activated in the cochlea following impulse noise exposure. Inhibition of p53 with pifithr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74463ccaf20f7bcb1fa8b900b04ea78b
https://pubmed.ncbi.nlm.nih.gov/24472721

Music as a unique source of noise-induced hearing loss.

Autor: Reynolds A; Department of Speech and Hearing Science, The Ohio State University, 110 Pressey Hall, 1070 Carmack Road, Columbus, OH 43210, USA., Bielefeld EC; Department of Speech and Hearing Science, The Ohio State University, 110 Pressey Hall, 1070 Carmack Road, Columbus, OH 43210, USA. Electronic address: bielefeld.6@osu.edu.

Publikováno v: Hearing research [Hear Res] 2023 Mar 15; Vol. 430, pp. 108706. Date of Electronic Publication: 2023 Jan 24.

Cochlear Preconditioning as a Modulator of Susceptibility to Hearing Loss.

Autor: Harrison RT; Department of Speech and Hearing Science, The Ohio State University, Columbus, Ohio, USA., DeBacker JR; Department of Speech and Hearing Science, The Ohio State University, Columbus, Ohio, USA., Trevino M; Callier Center for Communication Disorders, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, Texas, USA., Bielefeld EC; Department of Speech and Hearing Science, The Ohio State University, Columbus, Ohio, USA., Lobarinas E; Callier Center for Communication Disorders, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, Texas, USA.

Publikováno v: Antioxidants & redox signaling [Antioxid Redox Signal] 2022 Jun; Vol. 36 (16-18), pp. 1215-1228. Date of Electronic Publication: 2021 Jun 29.

Early Physiological and Cellular Indicators of Cisplatin-Induced Ototoxicity.

Autor: Chen Y; Translational Research Center, Department of Neurobiology and Anatomy, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.; Department of Physiology and Cell Biology, University of Nevada, Reno, Reno, NV, 95616, USA., Bielefeld EC; Department of Speech and Hearing Science, The Ohio State University, 110 Pressey Hall, 1070 Carmack Road, Columbus, OH, 43210, USA., Mellott JG; Translational Research Center, Department of Neurobiology and Anatomy, Northeast Ohio Medical University, Rootstown, OH, 44272, USA., Wang W; Translational Research Center, Department of Neurobiology and Anatomy, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.; School of Pharmacy, Anhui Medical University, Hefei, China., Mafi AM; Translational Research Center, Department of Neurobiology and Anatomy, Northeast Ohio Medical University, Rootstown, OH, 44272, USA., Yamoah EN; Department of Physiology and Cell Biology, University of Nevada, Reno, Reno, NV, 95616, USA., Bao J; Translational Research Center, Department of Neurobiology and Anatomy, Northeast Ohio Medical University, Rootstown, OH, 44272, USA. jbao@neomed.edu.

Publikováno v: Journal of the Association for Research in Otolaryngology : JARO [J Assoc Res Otolaryngol] 2021 Apr; Vol. 22 (2), pp. 107-126. Date of Electronic Publication: 2021 Jan 07.