Uncovering miRNA–mRNA Regulatory Networks Related to Olaparib Resistance and Resensitization of BRCA2 MUT Ovarian Cancer PEO1-OR Cells with the ATR/CHK1 Pathway Inhibitors.

Autor: Biegała, Łukasz^1,2 (AUTHOR) lukasz.biegala@edu.uni.lodz.pl, Kołat, Damian^3,4 (AUTHOR) damian.kolat@umed.lodz.pl, Gajek, Arkadiusz¹ (AUTHOR) arkadiusz.gajek@biol.uni.lodz.pl, Płuciennik, Elżbieta³ (AUTHOR) elzbieta.pluciennik@umed.lodz.pl, Marczak, Agnieszka¹ (AUTHOR) agnieszka.marczak@biol.uni.lodz.pl, Śliwińska, Agnieszka⁵ (AUTHOR) agnieszka.sliwinska@umed.lodz.pl, Mikula, Michał⁶ (AUTHOR) michal.mikula@nio.gov.pl, Rogalska, Aneta¹ (AUTHOR) agnieszka.sliwinska@umed.lodz.pl

Publikováno v: Cells (2073-4409). May2024, Vol. 13 Issue 10, p867. 31p.

PARP inhibitor resistance in ovarian cancer: Underlying mechanisms and therapeutic approaches targeting the ATR/CHK1 pathway

Autor: Biegała, Łukasz, Gajek, Arkadiusz, Marczak, Agnieszka, Rogalska, Aneta

Publikováno v: In BBA - Reviews on Cancer December 2021 1876(2)

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Molecular mechanisms restoring olaparib efficacy through ATR/CHK1 pathway inhibition in olaparib-resistant BRCA1/2 ^MUT ovarian cancer models.

Autor: Biegała Ł; Department of Medical Biophysics, Institute of Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska Street, 90-236 Lodz, Poland. Electronic address: lukasz.biegala@edu.uni.lodz.pl., Statkiewicz M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 5 Roentgena Street, 02-781 Warsaw, Poland. Electronic address: malgorzata.statkiewicz@nio.gov.pl., Gajek A; Department of Medical Biophysics, Institute of Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska Street, 90-236 Lodz, Poland. Electronic address: arkadiusz.gajek@biol.uni.lodz.pl., Szymczak-Pajor I; Department of Nucleic Acid Biochemistry, Medical University of Lodz, 251 Pomorska Street, 92-213 Lodz, Poland. Electronic address: izabela.szymczak@umed.lodz.pl., Rusetska N; Department of Experimental Immunology, Maria Sklodowska-Curie National Research Institute of Oncology, 5 Roentgena Street, 02-781 Warsaw, Poland. Electronic address: natalia.rusetska@nio.gov.pl., Śliwińska A; Department of Nucleic Acid Biochemistry, Medical University of Lodz, 251 Pomorska Street, 92-213 Lodz, Poland. Electronic address: agnieszka.sliwinska@umed.lodz.pl., Marczak A; Department of Medical Biophysics, Institute of Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska Street, 90-236 Lodz, Poland. Electronic address: agnieszka.marczak@biol.uni.lodz.pl., Mikula M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 5 Roentgena Street, 02-781 Warsaw, Poland. Electronic address: michal.mikula@nio.gov.pl., Rogalska A; Department of Medical Biophysics, Institute of Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska Street, 90-236 Lodz, Poland. Electronic address: aneta.rogalska@biol.uni.lodz.pl.

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Nov 16; Vol. 1871 (2), pp. 167574. Date of Electronic Publication: 2024 Nov 16.