Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition.

Autor: Oleksak P; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic., Psotka M; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic., Vancurova M; Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Sapega O; Laboratory of Immunological and Tumour Models, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Bieblova J; Laboratory of Immunological and Tumour Models, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Reinis M; Laboratory of Immunological and Tumour Models, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Rysanek D; Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Mikyskova R; Laboratory of Immunological and Tumour Models, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Chalupova K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic., Malinak D; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic., Svobodova J; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic., Andrys R; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic., Rehulkova H; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic., Skopek V; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic., Ngoc Lam P; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic., Bartek J; Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.; Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark., Hodny Z; Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Musilek K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.

Publikováno v: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 410-424.

The Novel HDAC Inhibitor OBP-801 Promotes MHC Class I Presentation Through LMP2 Upregulation, Enhancing the PD-1-Targeting Therapy in Clear Cell Renal Cell Carcinoma.

Autor: Narukawa, Tsukasa^1,2 (AUTHOR) tnarukaw@koto.kpu-m.ac.jp, Yasuda, Shusuke¹ (AUTHOR) m-hori@koto.kpu-m.ac.jp, Horinaka, Mano¹ (AUTHOR) ktaniguc@koto.kpu-m.ac.jp, Taniguchi, Keiko¹ (AUTHOR) miemori@koto.kpu-m.ac.jp, Tsujikawa, Takahiro³ (AUTHOR) tu-ji@koto.kpu-m.ac.jp, Morita, Mie¹ (AUTHOR) tsakai@koto.kpu-m.ac.jp, Ukimura, Osamu² (AUTHOR), Sakai, Toshiyuki¹ (AUTHOR)

Publikováno v: Cancers. Dec2024, Vol. 16 Issue 23, p4058. 16p.

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Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure inhibit prostate tumor growth in TRAMP mice.

Autor: Mikyskova R; Department of Transgenic Models of Diseases, Institute of Molecular Genetics of the AS CR, v.v.i., Prague, Czech Republic.; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the ASCR, Prague, Czech Republic., Indrova M; Department of Transgenic Models of Diseases, Institute of Molecular Genetics of the AS CR, v.v.i., Prague, Czech Republic.; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the ASCR, Prague, Czech Republic., Stepanek I; Department of Transgenic Models of Diseases, Institute of Molecular Genetics of the AS CR, v.v.i., Prague, Czech Republic.; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the ASCR, Prague, Czech Republic., Kanchev I; Department of Transgenic Models of Diseases, Institute of Molecular Genetics of the AS CR, v.v.i., Prague, Czech Republic.; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the ASCR, Prague, Czech Republic., Bieblova J; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the ASCR, Prague, Czech Republic., Vosahlikova S; SOTIO, a.s., Prague, Czech Republic., Moserova I; SOTIO, a.s., Prague, Czech Republic., Truxova I; SOTIO, a.s., Prague, Czech Republic., Fucikova J; Department of Immunology, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic.; SOTIO, a.s., Prague, Czech Republic., Bartunkova J; Department of Immunology, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic.; SOTIO, a.s., Prague, Czech Republic., Spisek R; Department of Immunology, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic.; SOTIO, a.s., Prague, Czech Republic., Sedlacek R; Department of Transgenic Models of Diseases, Institute of Molecular Genetics of the AS CR, v.v.i., Prague, Czech Republic.; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the ASCR, Prague, Czech Republic., Reinis M; Department of Transgenic Models of Diseases, Institute of Molecular Genetics of the AS CR, v.v.i., Prague, Czech Republic.; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the ASCR, Prague, Czech Republic.

Publikováno v: Oncoimmunology [Oncoimmunology] 2017 Aug 24; Vol. 6 (12), pp. e1362528. Date of Electronic Publication: 2017 Aug 24 (Print Publication: 2017).

Senescence Promotes the Recovery of Stemness among Cancer Cells via Reprograming.

Autor: Wang, Di¹ (AUTHOR) judywang1213@163.com, Liu, Lingbo¹ (AUTHOR) liulingbo@hust.edu.cn

Publikováno v: Biomolecules (2218-273X). Mar2024, Vol. 14 Issue 3, p288. 22p.