Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Biebele Abel"'
Autor:
Maria João Moreno, Hugo A. L. Filipe, Susana V. P. Cunha, Cristiana V. Ramos, Patrícia A. T. Martins, Biebele Abel, Luís M. S. Loura, Suresh V. Ambudkar
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 174 (2023)
The transport of drugs by efflux transporters in biomembranes limits their bioavailability and is a major determinant of drug resistance development by cancer cells and pathogens. A large number of chemically dissimilar drugs are transported, and des
Externí odkaz:
https://doaj.org/article/254c0ff6fc114e2ea036bbb3622ea762
Autor:
Maria João Moreno, Patrícia Alexandra Teles Martins, Eva F. Bernardino, Biebele Abel, Suresh V. Ambudkar
Publikováno v:
Biomolecules, Vol 11, Iss 3, p 426 (2021)
The lipid composition of biomembranes influences the properties of the lipid bilayer and that of the proteins. In this study, the lipidome and the lipid/protein ratio of membranes from High Five™ insect cells overexpressing mouse P-glycoprotein was
Externí odkaz:
https://doaj.org/article/768c0aaf677f40b28992e86d84ccb59c
Publikováno v:
Nano Biomedicine and Engineering, Vol 7, Iss 3, Pp 92-101 (2015)
We report the enhancement of chemiluminescence response of horseradish peroxidase (HRP) in bioassays by plasmonic surfaces, which are comprised of (i) silver island films (SIFs) and (ii) metal thin films (silver, gold, copper, and nickel, 1 nm thick)
Externí odkaz:
https://doaj.org/article/9b8328d9c2bb4542a6f923514ea5053d
De-crystallization of Uric Acid Crystals in Synovial Fluid Using Gold Colloids and Microwave Heating
Autor:
Bridgit Kioko, Taiwo Ogundolie, Morenike Adebiyi, Yehnara Ettinoffe, Caleb Rhodes, Brittney Gordon, Nishone Thompson, Muzaffer Mohammed, Biebele Abel, Kadir Aslan
Publikováno v:
Nano Biomedicine and Engineering, Vol 6, Iss 4, Pp 104-110 (2014)
In this study, we demonstrated a unique application of our Metal-Assisted and Microwave-Accelerated Evaporative Crystallization (MA-MAEC) technique for the de-crystallization of uric acid crystals, which causes gout in humans when monosodium urate cr
Externí odkaz:
https://doaj.org/article/641933e0739645228f73d5404683b8f5
Autor:
Biebele Abel, Kadir Aslan
Publikováno v:
Nano Biomedicine and Engineering, Vol 4, Iss 1, Pp 23-28 (2012)
Surface modification of silver island films (SIFs) was carried out with Biotin-Poly (Ethylene-glycol)-Amine (BEA), which acts as a cross-linker between the silver surface and horse radish peroxidase (HRP) enzyme for optimum plasmon-enhanced enzymatic
Externí odkaz:
https://doaj.org/article/fd6fc26f437a429b84eb891192074efd
Publikováno v:
Nano Biomedicine and Engineering, Vol 3, Iss 3, Pp 184-191 (2011)
A detailed investigation of the dependence of the efficiency of plasmon-enhanced enzymatic reactions on the distance between silver island films (SIFs) and horse radish peroxidase (HRP) enzyme and on the loading of SIFs on glass surfaces is presented
Externí odkaz:
https://doaj.org/article/1f1620cb18ca42edaea8fee4a86a4f6c
Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein
Autor:
Sabrina Lusvarghi, Andaleeb Sajid, Eduardo E. Chufan, Biebele Abel, Stewart R. Durell, Megumi Murakami, Suresh V. Ambudkar, Michael M Gottesman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The multidrug transporter P-glycoprotein protects tissues from xenobiotics and other toxic compounds by pumping them out of cells. This transporter has been implicated in altering the bioavailability of chemotherapeutic drugs and in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803755c3b785af07ef4d895aca61b154
https://doi.org/10.1073/pnas.2016270117
https://doi.org/10.1073/pnas.2016270117
Autor:
Biebele Abel, Megumi Murakami, Dilip K. Tosh, Jinha Yu, Sabrina Lusvarghi, Ryan G. Campbell, Zhan-Guo Gao, Kenneth A. Jacobson, Suresh V. Ambudkar
Publikováno v:
Eur J Med Chem
Various adenosine receptor nucleoside-like ligands were found to modulate ATP hydrolysis by the multidrug transporter ABCG2. Both ribose-containing and rigidified (N)-methanocarba nucleosides (C2-, N(6)- and 5’-modified), as well as adenines (C2-,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a031716a7441c2fe32a9eea583a9b4d
https://europepmc.org/articles/PMC8893036/
https://europepmc.org/articles/PMC8893036/
Publikováno v:
Biomolecules, Vol 11, Iss 426, p 426 (2021)
Biomolecules
Volume 11
Issue 3
Biomolecules
Volume 11
Issue 3
The lipid composition of biomembranes influence the properties of the lipid bilayer as well as that of the proteins. In this study, the lipidome and the lipid/protein ratio of membranes from High FiveTM insect cells overexpressing mouse P-glycoprotei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fb5ec7fc2a67f7443ad96c198ae4af
https://doi.org/10.20944/preprints202102.0204.v1
https://doi.org/10.20944/preprints202102.0204.v1
Autor:
Biebele Abel, Suresh V. Ambudkar, Anna Maria Barbuti, Zhe-Sheng Chen, Bhargav A. Patel, Tanaji T. Talele, Uday Kiran Velagapudi
Publikováno v:
Journal of Medicinal Chemistry. 61:834-864
A novel set of 64 analogues based on our lead compound 1 was designed and synthesized with an initial objective of understanding the structural requirements of ligands binding to a highly perplexing substrate-binding site of P-gp and their effect on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547344ff05923a98dea8fda3d5b1ebf8
https://doi.org/10.1021/acs.jmedchem.7b01340
https://doi.org/10.1021/acs.jmedchem.7b01340