Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Bidyottam Mittra"'
Autor:
Marco Túlio Alves da Silva, Ivan Rosa E Silva, Lívia Maria Faim, Natália Karla Bellini, Murilo Leão Pereira, Ana Laura Lima, Teresa Cristina Leandro de Jesus, Fernanda Cristina Costa, Tatiana Faria Watanabe, Humberto D'Muniz Pereira, Sandro Roberto Valentini, Cleslei Fernando Zanelli, Júlio Cesar Borges, Marcio Vinicius Bertacine Dias, Júlia Pinheiro Chagas da Cunha, Bidyottam Mittra, Norma W Andrews, Otavio Henrique Thiemann
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008091 (2020)
Eukaryotes from the Excavata superphylum have been used as models to study the evolution of cellular molecular processes. Strikingly, human parasites of the Trypanosomatidae family (T. brucei, T. cruzi and L. major) conserve the complex machinery res
Externí odkaz:
https://doaj.org/article/de528c663a0948819c80e6d01caa7959
Autor:
Bidyottam Mittra, Maria Fernanda Laranjeira-Silva, Juliana Perrone Bezerra de Menezes, Jennifer Jensen, Vladimir Michailowsky, Norma W Andrews
Publikováno v:
PLoS Pathogens, Vol 12, Iss 1, p e1005340 (2016)
Iron, an essential co-factor of respiratory chain proteins, is critical for mitochondrial function and maintenance of its redox balance. We previously reported a role for iron uptake in differentiation of Leishmania amazonensis into virulent amastigo
Externí odkaz:
https://doaj.org/article/5ca421a0b9cd400da7370ff2717829ed
Autor:
Lisvane Paes-Vieira, Bidyottam Mittra, Nathália Rocco-Machado, Michelle T. C. Nascimento, D. Cosentino-Gomes, Yousuf A. Khan, Norma W. Andrews, José Roberto Meyer-Fernandes
Publikováno v:
Free Radical Biology and Medicine. 143:341-353
Leishmania amazonensis is one of leishmaniasis' causative agents, a disease that has no cure and leads to the appearance of cutaneous lesions. Recently, our group showed that heme activates a Na+/K+ ATPase in these parasites through a signaling casca
Autor:
Matthias Corrotte, Davi A. G. Mázala, Bidyottam Mittra, Yan Wang, Eva R. Chin, Vladimir Michailowsky, Richard M. Lovering, Shama R. Iyer, H. Li, Norma W. Andrews
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-15 (2019)
Skeletal Muscle
Skeletal Muscle
Background Niemann-Pick disease type A (NPDA), a disease caused by mutations in acid sphingomyelinase (ASM), involves severe neurodegeneration and early death. Intracellular lipid accumulation and plasma membrane alterations are implicated in the pat
Autor:
Lucia Xiang, Fernando Y. Maeda, Jason Hauzel, Maria Fernanda Laranjeira-Silva, Norma W. Andrews, Bidyottam Mittra
Publikováno v:
Infect Immun
The molecular mechanisms underlying biological differences between two Leishmania species that cause cutaneous disease, L. major and L. amazonensis, are poorly understood. In L. amazonensis, reactive oxygen species (ROS) signaling drives differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7f5785cc4e354d357e684512646706
https://europepmc.org/articles/PMC6867856/
https://europepmc.org/articles/PMC6867856/
Autor:
Norma W. Andrews, Juliana Perrone Bezerra de Menezes, Bidyottam Mittra, Maria Fernanda Laranjeira-Silva, Danilo C. Miguel
Publikováno v:
Journal of Biological Chemistry. 292:12324-12338
Leishmaniasis is one of the leading globally neglected diseases, affecting millions of people worldwide. Leishmania infection depends on the ability of insect-transmitted metacyclic promastigotes to invade mammalian hosts, differentiate into amastigo
Autor:
Maria Fernanda Laranjeira-Silva, Norma W. Andrews, Amrita Sarkar, Yousuf A. Khan, Bidyottam Mittra
Publikováno v:
Journal of Visualized Experiments.
The lifecycle of Leishmania, the causative agent of leishmaniasis, alternates between promastigote and amastigote stages inside the insect and vertebrate hosts, respectively. While pathogenic symptoms of leishmaniasis can vary widely, from benign cut
Leishmaniavirulence and disease development critically depends on the ability ofLeishmaniapromastigotes to infect, differentiate into amastigote forms and replicate inside mammalian host macrophages. Understanding changes associated with amastigote d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b475463b0f4116cf36d3e4006658be2
https://europepmc.org/articles/PMC6513352/
https://europepmc.org/articles/PMC6513352/
Publikováno v:
Infection and Immunity. 81:3620-3626
The protozoan parasite Leishmania amazonensis is a heme auxotroph and must acquire this essential factor from the environment. Previous studies showed that L. amazonensis incorporates heme through the transmembrane protein LHR1 (L eishmania H eme R e
Autor:
Norma W. Andrews, Lisvane Paes Vieira, Michelle T. C. Nascimento, Bidyottam Mittra, Daniela Betzler Cardoso Gomes, José Roberto Meyer Fernandes, Nathália Machado
Publikováno v:
Free Radical Biology and Medicine. 128:S55
Leishmania amazonensis is one of leishmaniasis’ causative agent, a disease that has no cure and leads the appearance of cutaneous lesions. Recently, our group showed that heme activates a Na+/K+ ATPase in these parasites through a signaling cascade