Temporal trends in prevalence of Plasmodium falciparum molecular markers selected for by artemether–lumefantrine treatment in pre-ACT and post-ACT parasites in western Kenya

Autor: Angela O. Achieng, Peninah Muiruri, Luicer A. Ingasia, Benjamin H. Opot, Dennis W. Juma, Redemptah Yeda, Bidii S. Ngalah, Bernhards R. Ogutu, Ben Andagalu, Hoseah M. Akala, Edwin Kamau

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 5, Iss 3, Pp 92-99 (2015)

Artemether–lumefantrine (AL) became the first-line treatment for uncomplicated malaria in Kenya in 2006. Studies have shown AL selects for SNPs in pfcrt and pfmdr1 genes in recurring parasites compared to the baseline infections. The genotypes asso

Externí odkaz: https://doaj.org/article/abbbeff2eee247d5bab114bd5d409723

Selective sweeps and genetic lineages of Plasmodium falciparum multi-drug resistance (pfmdr1) gene in Kenya

Autor: Benjamin Opot, Denis W. Juma, Peninah Muiruri, Luicer A. Ingasia, Jelagat Cheruiyot, Lorna J. Chebon, Joseph K. Ng’ang’a, Hoseah M. Akala, Edwin Kamau, Venny C. S. Nyambati, Bidii S. Ngalah, Ben Andagalu

Publikováno v: Malaria Journal, Vol 17, Iss 1, Pp 1-12 (2018)
Malaria Journal

Background There are concerns that resistance to artemisinin-based combination therapy might emerge in Kenya and sub-Saharan Africa (SSA) in the same pattern as was with chloroquine and sulfadoxine–pyrimethamine. Single nucleotide polymorphisms (SN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01560b976ba05dec7908b2c014459e3f
https://doi.org/10.1186/s12936-018-2534-8

Trends in drug resistance codons in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Kenyan parasites from 2008 to 2012

Autor: Jelagat Cheruiyot, Luiser A. Ingasia, Redemptah Yeda, Ben Andagalu, Benjamin Opot, Edwin Kamau, Charles Okudo, Peninnah Muiruri, Fredrick Eyase, Wallace D. Bulimo, Hoseah M. Akala, Bidii S. Ngalah, Jacob D. Johnson, Angela A. Omondi, Dennis W. Juma, Agnes C. Cheruiyot, Lorna J. Chebon

Publikováno v: Malaria Journal

Background: Sulphadoxine-pyrimethamine (SP), an antifolate, was replaced by artemether-lumefantrine as the first-line malaria drug treatment in Kenya in 2004 due to the wide spread of resistance. However, SP still remains the recommended drug for int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed45850d23bdbe86207bc520607d2414
https://doi.org/10.1186/1475-2875-13-250

Temporal trends in prevalence of Plasmodium falciparum molecular markers selected for by artemether–lumefantrine treatment in pre-ACT and post-ACT parasites in western Kenya

Autor: Luicer A. Ingasia, Bernhards Ogutu, Peninah Muiruri, Hoseah M. Akala, Benjamin Opot, Redemptah Yeda, Angela O. Achieng, Ben Andagalu, Bidii S. Ngalah, Dennis W. Juma, Edwin Kamau

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 5, Iss 3, Pp 92-99 (2015)
International Journal for Parasitology: Drugs and Drug Resistance

Artemether–lumefantrine (AL) became the first-line treatment for uncomplicated malaria in Kenya in 2006. Studies have shown AL selects for SNPs in pfcrt and pfmdr1 genes in recurring parasites compared to the baseline infections. The genotypes asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2110f3beac343a48009b81e057fe8f4

Kin Recognition in Protists and Other Microbes: Genetics, Evolution, Behavior and Health

Autor: Guillermo Paz-y-Miño-C, Author

Kin Recognition in Protists and Other Microbes is the first volume dedicated entirely to the genetics, evolution and behavior of cells capable of discriminating and recognizing taxa (other species), clones (other cell lines) and kin (as per gradual g