Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Bidhan Chandra De"'
Autor:
Chunfang Yang, Liping Zhang, Wenjun Zhang, Chunshuai Huang, Yiguang Zhu, Xiaodong Jiang, Wei Liu, Mengran Zhao, Bidhan Chandra De, Changsheng Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The biosynthesis of xanthones has not been well documented. Here, the authors report that monooxygenase FlsO1 catalyzes three successive oxidations – hydroxylation, epoxidation and Baeyer–Villiger oxidation—to form the xanthone scaffold in acti
Externí odkaz:
https://doaj.org/article/7f4ad123515646149bcf976044cb2866
Autor:
Bidhan Chandra De, Wenjun Zhang, Chunfang Yang, Attila Mándi, Chunshuai Huang, Liping Zhang, Wei Liu, Mark W. Ruszczycky, Yiguang Zhu, Ming Ma, Ghader Bashiri, Tibor Kurtán, Hung-wen Liu, Changsheng Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Epoxide ring opening reactions are important in both biological processes and synthetic applications. Here, the authors show that flavin cofactors can catalyze reductive and oxidative epoxide ring opening reactions and propose the underlying mechanis
Externí odkaz:
https://doaj.org/article/fb5a7530f2fc41d8bb074811b01d97b6
Autor:
Chunshuai Huang, Chunfang Yang, Wenjun Zhang, Liping Zhang, Bidhan Chandra De, Yiguang Zhu, Xiaodong Jiang, Chunyan Fang, Qingbo Zhang, Cheng-Shan Yuan, Hung-wen Liu, Changsheng Zhang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Benzofluorene-containing angucyclines, bacterial natural compounds with potential use as therapeutics/antibiotics, occur as dimers. Here, the authors elucidated the dimerization mechanism which turned out to work spontaneously, without enzymatic cata
Externí odkaz:
https://doaj.org/article/30344ff8e3c44b39b61e7fdaf8585390
Autor:
Biswajit Brahma, Mahesh Chandra Patra, Satyanagalakshmi Karri, Meenu Chopra, Purusottam Mishra, Bidhan Chandra De, Sushil Kumar, Sourav Mahanty, Kiran Thakur, Krishna Mohan Poluri, Tirtha Kumar Datta, Sachinandan De
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144741 (2015)
Cathelicidins are an ancient class of antimicrobial peptides (AMPs) with broad spectrum bactericidal activities. In this study, we investigated the diversity and biological activity of cathelicidins of buffalo, a species known for its disease resista
Externí odkaz:
https://doaj.org/article/647cee66ebbc479096aede5816a3f55c
Autor:
Biswajit Brahma, Sushil Kumar, Bidhan Chandra De, Purusottam Mishra, Mahesh Chandra Patra, Deepak Gaur, Meenu Chopra, Devika Gautam, Sourav Mahanty, Hrudananda Malik, Dhruba Malakar, Tirtha Kumar Datta, Sachinandan De
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119178 (2015)
Nucleotide binding and oligomerization domain (NOD)-like receptors (NLRs) are innate immune receptors that recognize bacterial cell wall components and initiate host immune response. Structure and function of NLRs have been well studied in human and
Externí odkaz:
https://doaj.org/article/036158dbc68a49a090714ea00add7c02
Autor:
Manvender Singh, Biswajit Brahma, Jitendra Maharana, Mahesh Chandra Patra, Sushil Kumar, Purusottam Mishra, Megha Saini, Bidhan Chandra De, Sourav Mahanty, Tirtha Kumar Datta, Sachinandan De
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89788 (2014)
RIG1 and MDA5 have emerged as important intracellular innate pattern recognition receptors that recognize viral RNA and mediate cellular signals controlling Type I interferon (IFN-I) response. Buffalo RIG1 and MDA5 genes were investigated to understa
Externí odkaz:
https://doaj.org/article/0ebff45a057b4edb8179d3dac12a4a53
Autor:
Attila Mándi, Bidhan Chandra De, Yiguang Zhu, Zhuangjie Fang, Changsheng Zhang, Li-Ping Zhang, Wenjun Zhang, Chunfang Yang, Tibor Kurtán
Publikováno v:
J Biol Chem
Epoxide hydrolases (EHs) have been characterized and engineered as biocatalysts that convert epoxides to valuable chiral vicinal diol precursors of drugs and bioactive compounds. Nonetheless, the regioselectivity control of the epoxide ring opening b
Autor:
Yiguang Zhu, Haibo Zhang, Zhiwen Liu, Qingbo Zhang, Bidhan Chandra De, Li-Ping Zhang, Bin Tan, Wenjun Zhang, Changsheng Zhang, Guangtao Zhang
Publikováno v:
Organicbiomolecular chemistry. 19(41)
Berninamycins are a class of thiopeptide antibiotics with potent activity against Gram-positive bacteria. Heterologous expression of the berninamycin (ber) biosynthetic gene cluster from marine-derived Streptomyces sp. SCSIO 11878 in different terres
Autor:
Tirtha Kumar Datta, Jitendra Maharana, Sachinandan De, Purusottam Mishra, Sushil Kumar, Mahesh Chandra Patra, Bidhan Chandra De, Sonika Ahlawat, Biswajit Brahma, Ashutosh Vats
Publikováno v:
Journal of Molecular Graphics and Modelling. 65:15-26
Nucleotide binding and oligomerization domain 2 (NOD2), a member of intracellular NOD-like receptors (NLRs) family, recognizes the bacterial peptidoglycan, muramyl dipeptide (MDP) and initiates host immune response. The precise ligand recognition mec
Autor:
Hung-wen Liu, Wenjun Zhang, Yiguang Zhu, Li-Ping Zhang, Chunfang Yang, Bidhan Chandra De, Chengshan Yuan, Xiaodong Jiang, Qingbo Zhang, Chunshuai Huang, Chunyan Fang, Changsheng Zhang
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Lomaiviticin A and difluostatin A are benzofluorene-containing aromatic polyketides in the atypical angucycline family. Although these dimeric compounds are potent antitumor agents, how nature constructs their complex structures remains poorly unders