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Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer

Autor: Zuber, V., Bettella, F., Witoelar, A.W., Andreassen, O.A., Mills, I.G., Urbanucci, A., Eeles, R.A., Easton, D.F., Kote-Jarai, Z., Al Olama, A.A., Benlloch, S., Muir, K., Giles, G.G., Wiklund, F., Grönberg, H., Haiman, C.A., Schleutker, J., Weischer, M., Travis, R.C., Neal, D., Pharoah, P., Khaw, K.T., Stanford, J.L., Blot, W.J., Thibodeau, S.N., Maier, C., Kibel, A.S., Cybulski, C., Cannon-Albright, L., Brenner, H., Park, J., Kaneva, R., Batra, J., Teixeira, M.R., Pandha, H., Chenevix-Trench, G., Humphreys, M.K., Hung, R.J., Han, Y., Brennan, P., Bickeböller, H., Rosenberger, A., Houlston, R.S., Caporaso, N., Landi, M.T., Heinrich, J., Risch, A., Wu, X., Ye, Y., Christiani, D.C., Amos, C.I., Michailidou, K., Bolla, M.K., Wang, Q., Berchuck, A., Antoniou, A.C., McGuffog, L., Couch, F.J., Offit, K., Dennis, J., Dunning, A.M., Lee, A., Dicks, E., Luccarini, C., Benítez, J., González-Neira, A., Simard, J., Tessier, D.C., Bacot, F., Vincent, D., Laboissiere, S.

Publikováno v: Zuber, V, Bettella, F, Witoelar, A, Andreassen, O A, Mills, I G, Urbanucci, A & PRACTICAL Consortium 2017, ' Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer ', BMC Genomics, vol. 18, no. 1, pp. 270 . https://doi.org/10.1186/s12864-017-3620-y
BMC Genomics 18:270 (2017)
BMC Genomics

Background Epigenetic information can be used to identify clinically relevant genomic variants single nucleotide polymorphisms (SNPs) of functional importance in cancer development. Super-enhancers are cell-specific DNA elements, acting to determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::133f15c80a2e8e02e0caa94528d115e8
https://doi.org/10.1186/s12864-017-3620-y

Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer

Autor: Zuber, Verena, Bettella, Francesco, Witoelar, Aree, Andreassen, Ole A., Mills, Ian G., Urbanucci, Alfonso, Eeles, Rosalind, Easton, Doug, Kote-Jarai, Zsofia, Al Olama, Ali Amin, Benlloch, Sara, Muir, Kenneth, Giles, Graham G., Wiklund, Fredrik, Gronberg, Henrik, Haiman, Christopher A., Schleutker, Johanna, Weischer, Maren, Travis, Ruth C., Neal, David, Pharoah, Paul, Khaw, Kay Tee, Stanford, Janet L., Blot, William J., Thibodeau, Stephen, Maier, Christiane, Kibel, Adam S., Cybulski, Cezary, Cannon-Albright, Lisa, Brenner, Hermann, Park, Jong, Kaneva, Radka, Batra, Jyotsna, Teixeira, Manuel R., Pandha, Hardev, Chenevix-Trench, Georgia, Humphreys, Manjeet, Hung, R. J., Han, Y., Brennan, P., Bickeböller, H., Rosenberger, A., Houlston, R. S., Caporaso, N., Landi, M. T., Wu, X., Wang, Qin, Bojesen, Stig E., Nielsen, Sune F., Nordestgaard, Borge G.

Publikováno v: Zuber, V, Bettella, F, Witoelar, A, Andreassen, O A, Mills, I G, Urbanucci, A, Eeles, R, Easton, D, Kote-Jarai, Z, Al Olama, A A, Benlloch, S, Muir, K, Giles, G G, Wiklund, F, Gronberg, H, Haiman, C A, Schleutker, J, Weischer, M, Travis, R C, Neal, D, Pharoah, P, Khaw, K T, Stanford, J L, Blot, W J, Thibodeau, S, Maier, C, Kibel, A S, Cybulski, C, Cannon-Albright, L, Brenner, H, Park, J, Kaneva, R, Batra, J, Teixeira, M R, Pandha, H, Chenevix-Trench, G, Humphreys, M, Hung, R J, Han, Y, Brennan, P, Bickeböller, H, Rosenberger, A, Houlston, R S, Caporaso, N, Landi, M T, Wu, X, Wang, Q, Bojesen, S E, Nielsen, S F, Nordestgaard, B G & the PRACTICAL Consortium, the COGS-CRUK GWAS, the BCAC Consortium, the TRICL Consortium 2017, ' Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer ', BMC Genomics, vol. 18, 270 . https://doi.org/10.1186/s12864-017-3620-y

Background: Epigenetic information can be used to identify clinically relevant genomic variants single nucleotide polymorphisms (SNPs) of functional importance in cancer development. Super-enhancers are cell-specific DNA elements, acting to determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2751::8a71837b67e1f9184628fb7a4cdaa450
https://curis.ku.dk/portal/da/publications/bromodomain-protein-4-discriminates-tissuespecific-superenhancers-containing-diseasespecific-susceptibility-loci-in-prostate-and-breast-cancer(00cec9f4-a609-4444-80a8-ec33d2d98e63).html

Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R

Autor: Malzahn, D., Müller-Nurasyid, M., Heid, I.M., Wichmann, H.-E., Bickeböller, H., KORA Study Group (Gieger, C., Grallert, H., Heinrich, J., Holle, R., Leidl, R., Meisinger, C., Peters, A., Strauch, K.)

Publikováno v: Eur. J. Hum. Genet. 22, 1217-1224 (2014)

Among the single-nucleotide polymorphisms (SNPs) previously reported to be associated with body mass index (BMI) and obesity, we focus on a common risk variant rs7566605 upstream of the insulin-induced gene 2 (INSIG2) gene and a rare protective varia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72469e96aa8d5c9579b93632bcac251
https://doi.org/10.1038/ejhg.2014.3

Case-Control Association Tests Correcting for Population Stratification.

Autor: Köhler, K.¹ karola.koehler@medizin.uni-goettingen.de, Bickeböller, H.¹

Publikováno v: Annals of Human Genetics. Jan2006, Vol. 70 Issue 1, p98-115. 18p. 4 Charts, 3 Graphs.