Nociceptor spontaneous activity is responsible for fragmenting non-rapid eye movement sleep in mouse models of neuropathic pain.

Autor: Alexandre C; Department of Neurosurgery, Neurosurgery Pain Research Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Miracca G; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.; FM Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Holanda VD; Department of Neurosurgery, Neurosurgery Pain Research Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Sharma A; Department of Neurosurgery, Neurosurgery Pain Research Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Kourbanova K; Department of Neurosurgery, Neurosurgery Pain Research Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Ferreira A; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.; FM Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Bicca MA; Department of Neurosurgery, Neurosurgery Pain Research Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Zeng X; FM Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Nassar VA; Department of Neurosurgery, Neurosurgery Pain Research Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Lee S; FM Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Kaur S; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA., Sarma SV; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA., Sacré P; Department of Electrical Engineering and Computer Science, School of Engineering, University of Liège, Liège, Belgium., Scammell TE; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA., Woolf CJ; FM Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Latremoliere A; Department of Neurosurgery, Neurosurgery Pain Research Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Apr 17; Vol. 16 (743), pp. eadg3036. Date of Electronic Publication: 2024 Apr 17.

Cannabinoid extract in microdoses ameliorates mnemonic and nonmnemonic Alzheimer's disease symptoms: a case report.

Autor: Ruver-Martins AC; Laboratório de Cannabis Medicinal e Ciência Psicodélica, Department of Medicine, Universidade Federal da Integração Latino-Americana, UNILA, Avenida Tarquínio Joslin dos Santos, 1000, Jardim Universitário I, Foz do Iguaçu, PR, Brazil., Bicca MA; Department of Neurosurgery and Neurosciences, Johns Hopkins University, Baltimore, MD, USA., de Araujo FS; Department of Chemistry, Universidade Federal do Paraná, Curitiba, PR, Brazil., de Noronha Sales Maia BHL; Department of Chemistry, Universidade Federal do Paraná, Curitiba, PR, Brazil., Pamplona FA; Laboratório de Cannabis Medicinal e Ciência Psicodélica, Department of Medicine, Universidade Federal da Integração Latino-Americana, UNILA, Avenida Tarquínio Joslin dos Santos, 1000, Jardim Universitário I, Foz do Iguaçu, PR, Brazil., da Silva EG; Laboratório de Cannabis Medicinal e Ciência Psicodélica, Department of Medicine, Universidade Federal da Integração Latino-Americana, UNILA, Avenida Tarquínio Joslin dos Santos, 1000, Jardim Universitário I, Foz do Iguaçu, PR, Brazil., Nascimento FP; Laboratório de Cannabis Medicinal e Ciência Psicodélica, Department of Medicine, Universidade Federal da Integração Latino-Americana, UNILA, Avenida Tarquínio Joslin dos Santos, 1000, Jardim Universitário I, Foz do Iguaçu, PR, Brazil. francisney.nascimento@unila.edu.br.

Publikováno v: Journal of medical case reports [J Med Case Rep] 2022 Jul 12; Vol. 16 (1), pp. 277. Date of Electronic Publication: 2022 Jul 12.

The Therapeutic and Diagnostic Potential of Amyloid β Oligomers Selective Antibodies to Treat Alzheimer's Disease.

Autor: Viola KL; Department of Neurobiology, Northwestern University, Evanston, IL, United States., Bicca MA; Department of Neurobiology, Northwestern University, Evanston, IL, United States., Bebenek AM; Illinois Mathematics and Science Academy, Aurora, IL, United States., Kranz DL; Department of Neurobiology, Northwestern University, Evanston, IL, United States., Nandwana V; Department of Materials Science and Engineering, Northwestern University, Evanston, IL, United States., Waters EA; Center for Advanced Molecular Imaging, Northwestern University, Evanston, IL, United States., Haney CR; Center for Advanced Molecular Imaging, Northwestern University, Evanston, IL, United States., Lee M; Department of Neurobiology, Northwestern University, Evanston, IL, United States., Gupta A; Illinois Mathematics and Science Academy, Aurora, IL, United States., Brahmbhatt Z; Illinois Mathematics and Science Academy, Aurora, IL, United States., Huang W; Department of Neurobiology, Northwestern University, Evanston, IL, United States., Chang TT; Small Animal Imaging Facility, Van Andel Research Institute, Grand Rapids, MI, United States.; Laboratory of Translational Imaging, Van Andel Research Institute, Grand Rapids, MI, United States., Peck A; Small Animal Imaging Facility, Van Andel Research Institute, Grand Rapids, MI, United States.; Laboratory of Translational Imaging, Van Andel Research Institute, Grand Rapids, MI, United States., Valdez C; Department of Neurobiology, Northwestern University, Evanston, IL, United States., Dravid VP; Illinois Mathematics and Science Academy, Aurora, IL, United States., Klein WL; Department of Neurobiology, Northwestern University, Evanston, IL, United States.; Department of Neurology, Northwestern University, Chicago, IL, United States.

Publikováno v: Frontiers in neuroscience [Front Neurosci] 2022 Jan 03; Vol. 15, pp. 768646. Date of Electronic Publication: 2022 Jan 03 (Print Publication: 2021).

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant.

Autor: Gonçalves ECD; Laboratory of Autoimmunity and Immunopharmacology (LAIF), Department of Health Sciences, Campus Araranguá, Universidade Federal de Santa Catarina, Araranguá 88906-072, Brazil.; Graduate Program of Neuroscience, Center of Biological Sciences, Campus Florianópolis, Universidade Federal de Santa Catarina, Florianópolis 88040-900, Brazil., Baldasso GM; Laboratory of Autoimmunity and Immunopharmacology (LAIF), Department of Health Sciences, Campus Araranguá, Universidade Federal de Santa Catarina, Araranguá 88906-072, Brazil., Bicca MA; Neurosurgery Department, Neurosurgery Pain Research institute, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA., Paes RS; Laboratory of Autoimmunity and Immunopharmacology (LAIF), Department of Health Sciences, Campus Araranguá, Universidade Federal de Santa Catarina, Araranguá 88906-072, Brazil., Capasso R; Department of Agricultural Sciences, University of Naples Federico II, 80,055 Portici, Italy., Dutra RC; Laboratory of Autoimmunity and Immunopharmacology (LAIF), Department of Health Sciences, Campus Araranguá, Universidade Federal de Santa Catarina, Araranguá 88906-072, Brazil.; Graduate Program of Neuroscience, Center of Biological Sciences, Campus Florianópolis, Universidade Federal de Santa Catarina, Florianópolis 88040-900, Brazil.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2020 Mar 29; Vol. 25 (7). Date of Electronic Publication: 2020 Mar 29.

A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies.

Autor: Cline EN; Department of Neurobiology, Northwestern University, Evanston, Illinois, USA., Das A; Department of Neurobiology, Northwestern University, Evanston, Illinois, USA., Bicca MA; Department of Neurobiology, Northwestern University, Evanston, Illinois, USA., Mohammad SN; Department of Neurobiology, Northwestern University, Evanston, Illinois, USA.; Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, USA., Schachner LF; Departments of Chemistry and Molecular Biosciences and the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA., Kamel JM; Department of Neurobiology, Northwestern University, Evanston, Illinois, USA., DiNunno N; Department of Neurobiology, Northwestern University, Evanston, Illinois, USA., Weng A; Department of Neurobiology, Northwestern University, Evanston, Illinois, USA., Paschall JD; Department of Neurobiology, Northwestern University, Evanston, Illinois, USA., Bu RL; Department of Neurobiology, Northwestern University, Evanston, Illinois, USA., Khan FM; Department of Neurobiology, Northwestern University, Evanston, Illinois, USA., Rollins MG; Department of Neurobiology, Northwestern University, Evanston, Illinois, USA., Ives AN; Departments of Chemistry and Molecular Biosciences and the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA., Shekhawat G; Department of Material Science and Engineering, Northwestern University, Evanston, Illinois, USA., Nunes-Tavares N; Instituo de Biofisica Carlo Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., de Mello FG; Instituo de Biofisica Carlo Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Compton PD; Departments of Chemistry and Molecular Biosciences and the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA., Kelleher NL; Departments of Chemistry and Molecular Biosciences and the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, USA., Klein WL; Department of Neurobiology, Northwestern University, Evanston, Illinois, USA.

Publikováno v: Journal of neurochemistry [J Neurochem] 2019 Mar; Vol. 148 (6), pp. 822-836. Date of Electronic Publication: 2019 Jan 29.