Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Bibiana Rius"'
Autor:
Aparajita Madhavan, Bernard P. Kok, Bibiana Rius, Julia M. D. Grandjean, Adekunle Alabi, Verena Albert, Ara Sukiasyan, Evan T. Powers, Andrea Galmozzi, Enrique Saez, R. Luke Wiseman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Signalling through the IRE1 arm of the unfolded protein response exerts both protective and harmful effects in obesity. Here the authors report that a selective pharmacologic activator of IRE1/XBP1s signalling stimulates an adaptive remodelling of li
Externí odkaz:
https://doaj.org/article/8188d276e8de4e5c9c51dd25ed502203
Autor:
Verónica García-Alonso, Esther Titos, Jose Alcaraz-Quiles, Bibiana Rius, Aritz Lopategi, Cristina López-Vicario, Per-Johan Jakobsson, Salvadora Delgado, Juanjo Lozano, Joan Clària
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153751 (2016)
Obesity induces white adipose tissue (WAT) dysfunction characterized by unremitting inflammation and fibrosis, impaired adaptive thermogenesis and increased lipolysis. Prostaglandins (PGs) are powerful lipid mediators that influence the homeostasis o
Externí odkaz:
https://doaj.org/article/846c5acf5e7e434a8009be6d308ef2e1
Autor:
Julia M. D. Grandjean, Verena Albert, Andrea Galmozzi, R. Luke Wiseman, Ara Sukiasyan, Enrique Saez, Bernard P. Kok, Aparajita Madhavan, Bibiana Rius, Evan T. Powers
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Nature Communications
Nature Communications
In obesity, signaling through the IRE1 arm of the unfolded protein response exerts both protective and harmful effects. Overexpression of the IRE1-regulated transcription factor XBP1s in liver or fat protects against obesity-linked metabolic deterior
Autor:
R. Luke Wiseman, Jaleh Mesgarzadeh, Isabelle C. Romine, Bibiana Rius, Jeffery W. Kelly, Ryan J Paxman
Publikováno v:
Blood Adv
Light chain (LC) amyloidosis (AL) involves the toxic aggregation of amyloidogenic immunoglobulin LCs secreted from a clonal expansion of diseased plasma cells. Current AL treatments use chemotherapeutics to ablate the AL plasma cell population. Howev
Autor:
Isabelle C. Romine, Jaleh Mesgarzadeh, Luke Wiseman, Ryan J Paxman, Bibiana Rius, Jeffery W. Kelly
SUMMARYThe plasma cell secretion and toxic aggregation of amyloidogenic immunoglobulin light chains (LCs) causes proteotoxicity in Light Chain Amyloidosis (AL). We recently identified endoplasmic reticulum (ER) proteostasis regulators such as compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63e0800af10906c06d318461561f3feb
https://doi.org/10.1101/2020.05.15.098145
https://doi.org/10.1101/2020.05.15.098145
Autor:
Courtney Shea, Jaime L. Masferrer, Alba Díaz, Marta Duran-Güell, Mark G. Currie, José Alcaraz-Quiles, Katherine C. Hall, Roger Flores-Costa, Bibiana Rius, Esther Titos, Mireia Casulleras, Joan Clària, Renee Sarno, Cristina López-Vicario
Publikováno v:
British Journal of Pharmacology. 175:953-967
Background and Purpose Non-alcoholic steatohepatitis (NASH) is the hepatic manifestation of metabolic syndrome and is characterized by steatosis, inflammation and fibrosis. Soluble guanylate cyclase (sGC) stimulation reduces inflammation and fibrosis
Publikováno v:
Molecular Aspects of Medicine. 58:83-92
White adipose tissue plays an important endocrine role in balancing metabolic homeostasis. During conditions of nutrient excess, as occurs in obesity, there is an expansion of adipose tissue mass associated with a state of "low-grade" inflammation in
Autor:
Vicente Arroyo, Andrea De Gottardi, Esther Titos, Cristina López-Vicario, Bibiana Rius, Henning Grønbæk, Aritz Lopategi, Pere Ginès, Ivo Graziadei, José Alcaraz-Quiles, Joan Clària, Mauro Bernardi, Marco Pavesi, Mireia Casulleras
Publikováno v:
Alcaraz-Quiles, J, Titos, E, Casulleras, M, Pavesi, M, López-Vicario, C, Rius, B, Lopategi, A, de Gottardi, A, Graziadei, I, Gronbaek, H, Ginès, P, Bernardi, M, Arroyo, V & Clària, J 2017, ' Polymorphisms in the IL-1 gene cluster influence systemic inflammation in patients at risk for acute-on-chronic liver failure ', Hepatology, vol. 65, no. 1, pp. 202-216 . https://doi.org/10.1002/hep.28896
Acute-on-chronic liver failure (ACLF) in cirrhosis is an increasingly recognized syndrome characterized by acute decompensation, organ failure(s) and high short-term mortality. Recent findings suggest that an overexuberant systemic inflammation plays
Autor:
Joseph C. Genereux, Vincent F. Vartabedian, Bibiana Rius, Maria T. A. Dendle, Song Qu, John J. Chen, R. Luke Wiseman, Eul Hyun Suh, Jeffery W. Kelly
Publikováno v:
Cell Chemical Biology. 23:1282-1293
Transthyretin (TTR) is a tetrameric serum protein associated with multiple systemic amyloid diseases. In these disorders, TTR aggregates in extracellular environments through a mechanism involving rate-limiting dissociation of the tetramer to monomer
Autor:
Ana González-Périz, Esther Titos, Marta Duran-Güell, Magnus Bäck, José Alcaraz-Quiles, Joan Clària, Ricard Corcelles, Ainitze Ibarzabal, Andres Laguna-Fernandez, Bibiana Rius, Ana Isabel Martínez-Puchol, Mireia Casulleras, Cristina López-Vicario
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Dipòsit Digital de la UB
Universidad de Barcelona
instname
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Dipòsit Digital de la UB
Universidad de Barcelona
Obesity comorbidities are closely associated with chronic low-grade adipose tissue inflammation. A number of SNPs associated with inflammation has been identified, underscoring the impact of genetic determinants on this process. Here, we screened SNP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98ce4533282169ae1e4b65b658e2587
http://hdl.handle.net/2445/126199
http://hdl.handle.net/2445/126199