Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Bibiana Bielekova"'
Autor:
Peter Kosa, Christopher Barbour, Mihael Varosanec, Alison Wichman, Mary Sandford, Mark Greenwood, Bibiana Bielekova
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Multiple sclerosis (MS) changes the composition of the CSF. Here the authors use patient samples and aggregate CSF biomarkers into models that predict disability across all MS phenotypes, and identify potentially causal mechanisms and molecular disea
Externí odkaz:
https://doaj.org/article/135390552a0f4626ba4c30a88f0bb58c
Autor:
Breanna J. Beers, Morgan N. Similuk, Rajarshi Ghosh, Bryce A. Seifert, Leila Jamal, Michael Kamen, Michael R. Setzer, Colleen Jodarski, Rylee Duncan, Devin Hunt, Madison Mixer, Wenjia Cao, Weimin Bi, Daniel Veltri, Eric Karlins, Lingwen Zhang, Zhiwen Li, Andrew J. Oler, Kathleen Jevtich, Yunting Yu, Haley Hullfish, Bibiana Bielekova, Pamela Frischmeyer-Guerrerio, An Dang Do, Laryssa A. Huryn, Kenneth N. Olivier, Helen C. Su, Jonathan J. Lyons, Christa S. Zerbe, V. Koneti Rao, Michael D. Keller, Alexandra F. Freeman, Steven M. Holland, Luis M. Franco, Magdalena A. Walkiewicz, Jia Yan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
PurposeThough copy number variants (CNVs) have been suggested to play a significant role in inborn errors of immunity (IEI), the precise nature of this role remains largely unexplored. We sought to determine the diagnostic contribution of CNVs using
Externí odkaz:
https://doaj.org/article/5a9a5d2c1d2843bb9d22ca82e9ec744f
Autor:
Ruturaj R. Masvekar, Peter Kosa, Kimberly Jin, Kerry Dobbs, Michael A. Stack, Riccardo Castagnoli, Virginia Quaresima, Helen C. Su, Luisa Imberti, Luigi D. Notarangelo, Bibiana Bielekova
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 5, Pp 622-632 (2022)
Abstract Objective Given the continued spread of coronavirus 2, the early predictors of coronavirus disease 19 (COVID‐19) associated mortality might improve patients' outcomes. Increased levels of circulating neurofilament light chain (NfL), a biom
Externí odkaz:
https://doaj.org/article/7b0696edb7774efab599b332deb079cd
Autor:
Erin Kelly, Mihael Varosanec, Peter Kosa, Vesna Prchkovska, David Moreno-Dominguez, Bibiana Bielekova
Publikováno v:
Frontiers in Radiology, Vol 2 (2022)
Composite MRI scales of central nervous system tissue destruction correlate stronger with clinical outcomes than their individual components in multiple sclerosis (MS) patients. Using machine learning (ML), we previously developed Combinatorial MRI s
Externí odkaz:
https://doaj.org/article/14079176d997486699c60cae8348cbbc
Publikováno v:
Frontiers in Radiology, Vol 2 (2022)
IntroductionBoth aging and multiple sclerosis (MS) cause central nervous system (CNS) atrophy. Excess brain atrophy in MS has been interpreted as “accelerated aging.” Current paper tests an alternative hypothesis: MS causes CNS atrophy by mechani
Externí odkaz:
https://doaj.org/article/8690db3b264f49ae9c294cde8261a186
Autor:
Peter Kosa, Ruturaj Masvekar, Mika Komori, Jonathan Phillips, Vighnesh Ramesh, Mihael Varosanec, Mary Sandford, Bibiana Bielekova
Publikováno v:
JCI Insight, Vol 7, Iss 15 (2022)
BACKGROUND Serum neurofilament light chain (sNFL) is becoming an important biomarker of neuro-axonal injury. Though sNFL correlates with CSF NFL (cNFL), 40% to 60% of variance remains unexplained. We aimed to mathematically adjust sNFL to strengthen
Externí odkaz:
https://doaj.org/article/c8adbf47009e449d893b779aa662c743
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Development of effective treatments requires understanding of disease mechanisms. For diseases of the central nervous system (CNS), such as multiple sclerosis (MS), human pathology studies and animal models tend to identify candidate disease mechanis
Externí odkaz:
https://doaj.org/article/870ef0593964475290090e7892e111e4
Publikováno v:
npj Digital Medicine, Vol 4, Iss 1, Pp 1-13 (2021)
Abstract As the burden of neurodegenerative diseases increases, time-limited clinic encounters do not allow quantification of complex neurological functions. Patient-collected digital biomarkers may remedy this, if they provide reliable information.
Externí odkaz:
https://doaj.org/article/3aff0db76c8b4145b5c4a76b8e9a85e9
Autor:
Komi S. Messan, Linh Pham, Thomas Harris, Yujin Kim, Vanessa Morgan, Peter Kosa, Bibiana Bielekova
Publikováno v:
Frontiers in Medical Technology, Vol 3 (2022)
Technological advances, lack of medical professionals, high cost of face-to-face encounters, and disasters such as the COVID-19 pandemic fuel the telemedicine revolution. Numerous smartphone apps have been developed to measure neurological functions.
Externí odkaz:
https://doaj.org/article/185c25e9cfc34502acb61cfaefb7bac9
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Multiple sclerosis (MS)-related inflammation can be divided into lesional activity, mediated by immune cells migrating from the periphery to the central nervous system (CNS) and non-lesional activity, mediated by inflammation compartmentalized to CNS
Externí odkaz:
https://doaj.org/article/ffc10dfe3f484b51945dd443dae215fa