Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Bibian M E, Tullemans"'
Autor:
Delia I. Fernández, Sara Troitiño, Vladimír Sobota, Bibian M. E. Tullemans, Jinmi Zou, Helma van den Hurk, Ángel García, Saman Honarnejad, Marijke J. E. Kuijpers, Johan W. M. Heemskerk
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Distinct platelet activation patterns are elicited by the tyrosine kinase-linked collagen receptor glycoprotein VI (GPVI) and the G-protein coupled protease-activated receptors (PAR1/4) for thrombin. This is reflected in the different platel
Externí odkaz:
https://doaj.org/article/e0e4cce4e1b944baa6e8d33649209870
Autor:
Bibian M. E. Tullemans, Sanne L. N. Brouns, Frauke Swieringa, Siamack Sabrkhany, Franchette W. P. J. van den Berkmortel, Natascha A. J. B. Peters, Peter de Bruijn, Stijn L. W. Koolen, Johan W. M. Heemskerk, Maureen J. B. Aarts, Marijke J. E. Kuijpers
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Tyrosine kinase inhibitors (TKIs), such as sunitinib, are used for cancer treatment, but may also affect platelet count and function with possible hemostatic consequences. Here, we investigated whether patient treatment with the T
Externí odkaz:
https://doaj.org/article/bac1127f83e544248d1468261a8425b1
Autor:
Johanna P. van Geffen, Frauke Swieringa, Kim van Kuijk, Bibian M. E. Tullemans, Fiorella A. Solari, Bing Peng, Kenneth J. Clemetson, Richard W. Farndale, Ludwig J. Dubois, Albert Sickmann, René P. Zahedi, Robert Ahrends, Erik A. L. Biessen, Judith C. Sluimer, Johan W. M. Heemskerk, Marijke J. E. Kuijpers
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract Hyperlipidemia is a well-established risk factor for cardiovascular diseases. Millions of people worldwide display mildly elevated levels of plasma lipids and cholesterol linked to diet and life-style. While the prothrombotic risk of severe
Externí odkaz:
https://doaj.org/article/1989a910cf91487588230cb6fcebb5c1
Autor:
Sanne L. N. Brouns, Bibian M. E. Tullemans, Cristiana Bulato, Gina Perrella, Elena Campello, Luca Spiezia, Johanna P. vanGeffen, Marijke J. E. Kuijpers, René vanOerle, Henri M. H. Spronk, Paola E. J. van derMeijden, Paolo Simioni, Johan W. M. Heemskerk
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 2, Pp n/a-n/a (2022)
Abstract Background Low plasma levels of protein C or protein S are associated with venous thromboembolism rather than myocardial infarction. The high coagulant activity in patients with thrombophilia with a (familial) defect in protein C or S is exp
Externí odkaz:
https://doaj.org/article/d84e1511f3664b1ea2f38cd31eef1b0c
Autor:
Annemiek Dickhout, Bibian M E Tullemans, Johan W M Heemskerk, Victor L J L Thijssen, Marijke J E Kuijpers, Rory R Koenen
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0244736 (2021)
Galectin-1 (gal-1) is a carbohydrate-binding lectin with important functions in angiogenesis, immune response, hemostasis and inflammation. Comparable functions are exerted by platelet factor 4 (CXCL4), a chemokine stored in the α-granules of platel
Externí odkaz:
https://doaj.org/article/311672ba243c452db493f5a61210ee1d
Autor:
Bibian M. E. Tullemans, Magdolna Nagy, Siamack Sabrkhany, Arjan W. Griffioen, Mirjam G. A. oude Egbrink, Maureen Aarts, Johan W. M. Heemskerk, Marijke J. E. Kuijpers
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2018)
Pazopanib is an angiostatic tyrosine kinase inhibitor (TKI) presently used for cancer treatment, particularly in patients with renal cell carcinoma (RCC). This treatment can be accompanied by mild bleeding as an adverse effect. Given the role of prot
Externí odkaz:
https://doaj.org/article/05bd1e87d2794475abf3d48437cee59b
Autor:
Alicia Veninga, Stefan Handtke, Konstanze Aurich, Bibian M. E. Tullemans, Sanne L. N. Brouns, Silas L. Schwarz, Floor C. J. I. Heubel-Moenen, Andreas Greinacher, Johan W. M. Heemskerk, Paola E. J. van der Meijden, Thomas Thiele
Publikováno v:
Blood advances, 6(14), 4162-4173. The American Society of Hematology
Platelets within one individual display heterogeneity in reactivity, size, age, and expression of surface receptors. To investigate the combined intraindividual contribution of platelet size, platelet age, and receptor expression levels on the reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fafbbab146d0c0d5586982a017f596cf
https://pubmed.ncbi.nlm.nih.gov/35561312
https://pubmed.ncbi.nlm.nih.gov/35561312
Autor:
Delia I. Fernandez, Alicia Veninga, Johan W. M. Heemskerk, Bibian M. E. Tullemans, Marijke J.E. Kuijpers, Paola E. J. van der Meijden, Johannes A. Eble, Maureen J.B. Aarts
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11199, p 11199 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 20; Pages: 11199
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 22(20):11199. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences; Volume 22; Issue 20; Pages: 11199
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 22(20):11199. Multidisciplinary Digital Publishing Institute (MDPI)
Current antiplatelet drugs for the treatment of arterial thrombosis often coincide with increased bleeding risk. Several tyrosine kinase inhibitors (TKIs) for cancer treatment inhibit platelet function, with minor reported bleeding symptoms. The aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c720f6cc7d39e64f998ef7a0facd8e
https://doi.org/10.3390/ijms222011199
https://doi.org/10.3390/ijms222011199
Autor:
Delia I, Fernández, Isabella, Provenzale, Hilaire Y F, Cheung, Jan, van Groningen, Bibian M E, Tullemans, Alicia, Veninga, Joanne L, Dunster, Saman, Honarnejad, Helma, van den Hurk, Marijke J E, Kuijpers, Johan W M, Heemskerk
Publikováno v:
iScience
Summary Antiplatelet drugs targeting G-protein-coupled receptors (GPCRs), used for the secondary prevention of arterial thrombosis, coincide with an increased bleeding risk. Targeting ITAM-linked receptors, such as the collagen receptor glycoprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f97c2fe61bab3374cc750d4a5247af7c
https://pubmed.ncbi.nlm.nih.gov/35072010
https://pubmed.ncbi.nlm.nih.gov/35072010
Tyrosine Kinase Inhibitor Sunitinib Delays Platelet-Induced Coagulation: Additive Effects of Aspirin
Autor:
Delia I. Fernandez, Marijke J.E. Kuijpers, L. Peters, Alicia Veninga, Maureen J.B. Aarts, Luca Spiezia, Bibian M. E. Tullemans, Emiel P. C. van der Vorst, Constance C.F.M.J. Baaten, Johannes A. Eble, Paolo Simioni, Elena Campello, Johan W. M. Heemskerk, Paola E. J. van der Meijden
Publikováno v:
Thrombosis and Haemostasis
Thrombosis and Haemostasis, 122(01), 92-104. Georg Thieme Verlag
Thrombosis and Haemostasis, 122(01), 92-104. Georg Thieme Verlag
Background Sunitinib is a multitarget tyrosine kinase inhibitor (TKI) used for cancer treatment. In platelets, sunitinib affects collagen-induced activation under noncoagulating conditions. We investigated (1) the effects of sunitinib on thrombus for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ea0b0f8e56e0942de8dcbba60dddb1
https://pubmed.ncbi.nlm.nih.gov/34130349
https://pubmed.ncbi.nlm.nih.gov/34130349