Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Biased signalling"'
Autor:
Thomas L. Williams, Duuamene Nyimanu, Rhoda E. Kuc, Richard Foster, Robert C. Glen, Janet J. Maguire, Anthony P. Davenport
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Pulmonary arterial hypertension (PAH) is characterised by endothelial dysfunction and pathological vascular remodelling, resulting in the occlusion of pulmonary arteries and arterioles, right ventricular hypertrophy, and eventually fata
Externí odkaz:
https://doaj.org/article/96d17a331f9240c6a1914d929b042de1
Autor:
Nathan Vanalken, Katrijn Boon, Martyna Szpakowska, Andy Chevigné, Dominique Schols, Tom Van Loy
Publikováno v:
Biosensors, Vol 14, Iss 3, p 142 (2024)
The human CC chemokine receptor 7 (CCR7) is activated by two natural ligands, CC chemokine ligand 19 (CCL19) and 21 (CCL21). The CCL19-CCL21-CCR7 axis has been extensively studied in vitro, but there is still debate over whether CCL21 is an overall w
Externí odkaz:
https://doaj.org/article/87288a5dd8eb4c5f9b90c39f35ab4fa2
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Gonadotropins regulate reproductive functions by binding to G protein-coupled receptors (FSHR and LHCGR) expressed in the gonads. They activate multiple, cell-specific signalling pathways, consisting of ligand-dependent intracellular events. Signalli
Externí odkaz:
https://doaj.org/article/89d2fefed892427aa8eaf8028228c8cf
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
G protein-coupled receptors (GPCRs) are capable of interacting to form higher order structures such as homomers and heteromers. Heteromerisation in particular has implications for receptor function, with research showing receptors can attain unique e
Externí odkaz:
https://doaj.org/article/bca4f33656444636bc98420ffa0346bc
Autor:
Agnieszka Olejarz-Maciej, Szczepan Mogilski, Tadeusz Karcz, Tobias Werner, Katarzyna Kamińska, Jarosław Kupczyk, Ewelina Honkisz-Orzechowska, Gniewomir Latacz, Holger Stark, Katarzyna Kieć-Kononowicz, Dorota Łażewska
Publikováno v:
Molecules, Vol 28, Iss 10, p 4199 (2023)
Pain is a very unpleasant experience that makes life extremely uncomfortable. The histamine H4 receptor (H4R) is a promising target for the treatment of inflammatory and immune diseases, as well as pain. H4R ligands have demonstrated analgesic effect
Externí odkaz:
https://doaj.org/article/a1345330633546a088998c7589f4d043
Autor:
Shee Chee Ong, Alessia Belgi, Allanah L. Merriman, Carlie A. Delaine, Bianca van Lierop, Sofianos Andrikopoulos, Andrea J. Robinson, Briony E. Forbes
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The mechanisms by which insulin activates the insulin receptor to promote metabolic processes and cellular growth are still not clear. Significant advances have been gained from recent structural studies in understanding how insulin binds to its rece
Externí odkaz:
https://doaj.org/article/a3aaeb206dde409cae3f877af9454a36
Akademický článek
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Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
G protein-coupled receptors (GPCRs) are the largest class of human membrane proteins that bind extracellular ligands at their orthosteric binding pocket to transmit signals to the cell interior. Ligand binding evokes conformational changes in GPCRs t
Externí odkaz:
https://doaj.org/article/2c243dd51919414db91bf9239483424d
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/90f0215f02cc403bb4eb8738d20fc4bf
Akademický článek
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