Zobrazeno 1 - 10
of 920
pro vyhledávání: '"Biased Signaling"'
Autor:
Quon, Tezz, Lin, Li-Chiung, Ganguly, Amlan, Hudson, Brian D., Tobin, Andrew B., Milligan, Graeme ∗
Publikováno v:
In Journal of Biological Chemistry January 2025 301(1)
Autor:
Shengnan Shen, Qiwen Liao, Liwei Gu, Yongping Zhu, Yanqing Liu, Xinwei Zhang, Junzhe Zhang, Qiaoli Shi, Yuxiang Sun, Jigang Wang, Ligen Lin
Publikováno v:
Acta Materia Medica, Vol 3, Iss 1, Pp 31-45 (2024)
G protein-coupled receptors (GPCRs) are important, potential drug targets for the treatment of metabolic disorders, such as obesity. GPCRs crosstalk with several transducers, including heterotrimeric G proteins, GPCR kinases (GRKs), and β-arrestins.
Externí odkaz:
https://doaj.org/article/ff691603cecd4052bd61b8b36d583a93
Autor:
Kelly Karl, Nuala Del Piccolo, Taylor Light, Tanaya Roy, Pooja Dudeja, Vlad-Constantin Ursachi, Bohumil Fafilek, Pavel Krejci, Kalina Hristova
Publikováno v:
eLife, Vol 12 (2024)
The differential signaling of multiple FGF ligands through a single fibroblast growth factor (FGF) receptor (FGFR) plays an important role in embryonic development. Here, we use quantitative biophysical tools to uncover the mechanism behind differenc
Externí odkaz:
https://doaj.org/article/59cd46cf169246dd8f9d3ba3c0045635
Autor:
Alexander O. Shpakov
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 9, p 313 (2024)
Luteinizing hormone (LH) and human chorionic gonadotropin (CG), like follicle-stimulating hormone, are the most important regulators of the reproductive system. They exert their effect on the cell through the LH/CG receptor (LHCGR), which belongs to
Externí odkaz:
https://doaj.org/article/71575645fffd43eab35407db513ad8cd
Autor:
Martina Chrudinová, Nicholas S. Kirk, Aurelien Chuard, Hari Venugopal, Fa Zhang, Marta Lubos, Vasily Gelfanov, Terezie Páníková, Lenka Žáková, Julianne Cutone, Matthew Mojares, Richard DiMarchi, Jiří Jiráček, Emrah Altindis
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101863- (2024)
Objective: The insulin/IGF superfamily is conserved across vertebrates and invertebrates. Our team has identified five viruses containing genes encoding viral insulin/IGF-1 like peptides (VILPs) closely resembling human insulin and IGF-1. This study
Externí odkaz:
https://doaj.org/article/7c5f60a2f83f44fdb26861620a039b02
Autor:
Emilio Y. Lucero‐Garcia Rojas, Arfaxad Reyes‐Alcaraz, Kehe Ruan, Bradley K. McConnell, Richard A. Bond
Publikováno v:
FASEB BioAdvances, Vol 4, Iss 12, Pp 758-774 (2022)
Abstract The β2AR is a prototypical G protein‐coupled receptor (GPCR) known to orchestrate different cellular responses by the stimulation of specific signaling pathways. The best‐established signaling pathways for the β2AR are the canonical Gs
Externí odkaz:
https://doaj.org/article/f1ee986d5c6b434dbf21a6fe72535b42
Akademický článek
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Akademický článek
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Publikováno v:
FEBS Open Bio, Vol 12, Iss 4, Pp 775-783 (2022)
EP2 and EP4 prostanoid receptors have long been considered to have similar roles, since they are known to couple with Gαs‐protein and activate cAMP‐mediated signaling pathways. In this study, we re‐evaluated the results of cAMP assays with or
Externí odkaz:
https://doaj.org/article/a79c29d70feb4edab4f9c5e3620c8d8f