Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Biaoxin Chai"'
Autor:
Vaibhav Sidarala, Gemma L. Pearson, Vishal S. Parekh, Benjamin Thompson, Lisa Christen, Morgan A. Gingerich, Jie Zhu, Tracy Stromer, Jianhua Ren, Emma C. Reck, Biaoxin Chai, John A. Corbett, Thomas Mandrup-Poulsen, Leslie S. Satin, Scott A. Soleimanpour
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Inflammatory damage contributes to β cell failure in type 1 and 2 diabetes (T1D and T2D, respectively). Mitochondria are damaged by inflammatory signaling in β cells, resulting in impaired bioenergetics and initiation of proapoptotic machinery. Hen
Externí odkaz:
https://doaj.org/article/5621b7dc174d44beb66d61a7da10a016
Autor:
Mathew, Anna V., Kayampilly, Pradeep, Byun, Jaeman, Nair, Viji, Afshinnia, Farsad, Biaoxin Chai, Brosius 3rd, Frank C., Kretzler, Matthias, Pennathur, Subramaniam
Publikováno v:
American Journal of Physiology: Renal Physiology; Jan2024, Vol. 326 Issue 1, pF30-F38, 9p
Autor:
Morgan A. Gingerich, Jie Zhu, Biaoxin Chai, Michael P. Vincent, Nuli Xie, Vaibhav Sidarala, Nicholas A. Kotov, Debashish Sahu, Daniel J. Klionsky, Santiago Schnell, Scott A. Soleimanpour
Publikováno v:
J Biol Chem
CLEC16A is an E3 ubiquitin ligase that regulates mitochondrial quality control through mitophagy and is associated with over 20 human diseases. CLEC16A forms a complex with another E3 ligase, RNF41, and a ubiquitin-specific peptidase, USP8; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0b980a599ac90631998397abb77960
https://europepmc.org/articles/PMC10066562/
https://europepmc.org/articles/PMC10066562/
Autor:
Morgan A, Gingerich, Xueying, Liu, Biaoxin, Chai, Gemma L, Pearson, Michael P, Vincent, Tracy, Stromer, Jie, Zhu, Vaibhav, Sidarala, Aaron, Renberg, Debashish, Sahu, Daniel J, Klionsky, Santiago, Schnell, Scott A, Soleimanpour
Publikováno v:
Autophagy
CLEC16A regulates mitochondrial health through mitophagy and is associated with over 20 human diseases. However, the key structural and functional regions of CLEC16A, and their relevance for human disease, remain unknown. Here, we report that a disea
Autor:
Morgan A. Gingerich, Xueying Liu, Biaoxin Chai, Gemma L. Pearson, Michael P. Vincent, Tracy Stromer, Jie Zhu, Vaibhav Sidarala, Aaron Renberg, Debashish Sahu, Daniel J. Klionsky, Santiago Schnell, Scott A. Soleimanpour
CLEC16A regulates mitochondrial health through mitophagy and is associated with over 20 human diseases. However, the key structural and functional regions of CLEC16A, and their relevance for human disease, remain unknown. Here, we report that a disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52afa66c37fbd5ed98968fda796e89eb
Autor:
Jie Zhu, Xueying Liu, Gemma L. Pearson, Aaron Renberg, Scott A. Soleimanpour, Vaibhav Sidarala, Debashish Sahu, Morgan A. Gingerich, Daniel J. Klionsky, Biaoxin Chai, Michael S. Vincent, Santiago Schnell, Tracy Stromer
CLEC16A regulates mitochondrial health through mitophagy and is associated with over 20 human diseases. While CLEC16A has ubiquitin ligase activity, the key structural and functional regions of CLEC16A, and their relevance for human disease, remain u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fca2367b58f28836f0dcde599da7b302
https://doi.org/10.1101/2021.09.03.458272
https://doi.org/10.1101/2021.09.03.458272
Autor:
Helgi B. Schiöth, Alex N. Eberle, Sadaf Farooqi, Biaoxin Chai, Roger D. Cone, Colin W. Pouton, Jeffrey B. Tatro, Vanni Caruso, Jarl E. S. Wikberg, Adrian J. L. Clark, Tung M. Fong, Carrie Haskell-Luevano, Victor J. Hruby, Kathleen G. Mountjoy, Ira Gantz
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [41]) are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH). Endogenous anta
Autor:
John A. Corbett, Emma C. Reck, Scott A. Soleimanpour, Biaoxin Chai, Morgan A. Gingerich, Benjamin Thompson, Lisa Christen, Thomas Mandrup-Poulsen, Vishal S. Parekh, Gemma L. Pearson, Vaibhav Sidarala, Leslie S. Satin, Jianhua Ren, Jie Zhu, Tracy Stromer
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 24 (2020)
Sidarala, V, Pearson, G L, Parekh, V S, Thompson, B, Christen, L, Gingerich, M A, Zhu, J, Stromer, T, Ren, J, Reck, E C, Chai, B, Corbett, J A, Mandrup-Poulsen, T, Satin, L S & Soleimanpour, S A 2020, ' Mitophagy protects beta cells from inflammatory damage in diabetes ', JCI insight, vol. 5, no. 24, 141138 . https://doi.org/10.1172/jci.insight.141138
JCI Insight, Vol 5, Iss 24 (2020)
Sidarala, V, Pearson, G L, Parekh, V S, Thompson, B, Christen, L, Gingerich, M A, Zhu, J, Stromer, T, Ren, J, Reck, E C, Chai, B, Corbett, J A, Mandrup-Poulsen, T, Satin, L S & Soleimanpour, S A 2020, ' Mitophagy protects beta cells from inflammatory damage in diabetes ', JCI insight, vol. 5, no. 24, 141138 . https://doi.org/10.1172/jci.insight.141138
Inflammatory damage contributes to β-cell failure in type 1 and 2 diabetes (T1D and T2D). Mitochondria are damaged by inflammatory signaling in β-cells, resulting in impaired bioenergetics and initiation of pro-apoptotic machinery. Hence, the ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95489b3a754e5976312f493596ac093
https://doi.org/10.1101/2020.06.07.138917
https://doi.org/10.1101/2020.06.07.138917
Autor:
Tracy D. Vozheiko, Malathi Kandarpa, Scott A. Soleimanpour, Gemma L. Pearson, Biaoxin Chai, Xueying Liu, Robert C. Piper
Publikováno v:
Diabetes
Mitophagy is a cellular quality-control pathway, which is essential for elimination of unhealthy mitochondria. While mitophagy is critical to pancreatic β-cell function, the posttranslational signals governing β-cell mitochondrial turnover are unkn
Publikováno v:
Endocrinology. 155:429-440
The hypothalamus plays a key role in the regulation of feeding behavior. Several hypothalamic nuclei, including the arcuate nucleus (ARC), paraventricular nucleus, and ventromedial nucleus of the hypothalamus (VMH), are involved in energy homeostasis