Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Biao Ruan"'
Publikováno v:
Journal of International Advanced Otology, Vol 19, Iss 3, Pp 255-259 (2023)
Externí odkaz:
https://doaj.org/article/4b6427d3431143848601f72ade02a017
Autor:
Biao Ruan, Yanan He, Yingwei Chen, Eun Jung Choi, Yihong Chen, Dana Motabar, Tsega Solomon, Richard Simmerman, Thomas Kauffman, D. Travis Gallagher, John Orban, Philip N. Bryan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
In this work the authors investigate the structure-sequence dependance. The ability to design and characterize proteins at interfaces between three common folds suggests that fold switching is an intrinsic feature of protein folding language and like
Externí odkaz:
https://doaj.org/article/9524664bc44a413a9ca8a35fb258616e
Autor:
Yingwei Chen, Eric A. Toth, Biao Ruan, Eun Jung Choi, Richard Simmerman, Yihong Chen, Yanan He, Ruixue Wang, Raquel Godoy-Ruiz, Harlan King, Gregory Custer, D. Travis Gallagher, David A. Rozak, Melani Solomon, Silvia Muro, David J. Weber, John Orban, Thomas R. Fuerst, Philip N. Bryan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Chen et al. describe a rational design of subtilisin mutants that degrade active RAS by cleaving a conserved sequence in switch 2. They further modified the active site to be dependent on a cofactor to generate high target specificity. Proteases engi
Externí odkaz:
https://doaj.org/article/742c1a3e0584400b8b631c6e4a1b0ff6
Autor:
Jing Ma, Ken Lin, Hong‐chao Jiang, Yanli Yang, Yu Zhang, Guilian Yang, Hao Sun, Cheng Ming, Xianyun Bi, Tiesong Zhang, Biao Ruan
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 7, Iss 7, Pp n/a-n/a (2019)
Abstract Background To analyze the clinical phenotypes and genetic variants of a Chinese family with Waardenburg syndrome (WS) and to explore the possible molecular pathogenesis of WS. Methods The clinical data from a patient and his family were coll
Externí odkaz:
https://doaj.org/article/93f6baa2a37d446fae611f367ca155e0
Autor:
Qiulin Liang, Ruiqing Long, Shuling Li, Chaowu Jiang, Jingyu Gao, Sheng Cheng, Zhuohui Liu, Biao Ruan
Here, the bacterial diversity in chronic suppurative otitis media (CSOM) and middle-ear cholesteatoma (MEC) was analysed. Nine and twenty-nine patients with CSOM and MEC, respectively, were recruited. Middle-ear lesion tissue was collected intraopera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4509d7ce1fe7dcdb59bc124fc1134abc
https://doi.org/10.21203/rs.3.rs-2990438/v1
https://doi.org/10.21203/rs.3.rs-2990438/v1
Autor:
Qiulin Liang, Ruiqing Long, Shuling Li, Chaowu Jiang, Jingyu Gao, Sheng Cheng, Zhuohui Liu, Biao Ruan
Publikováno v:
Functional & Integrative Genomics. 23
In this study, the bacterial diversity of acquired middle ear cholesteatoma (MEC) was evaluated to reveal its pathogenesis and provides a guide for the use of antibiotics. Twenty-nine cases of acquired MEC and eight cases of healthy middle ears under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf1da8e84c499226dbf3b45ba4409b31
https://doi.org/10.1007/s10142-023-01068-2
https://doi.org/10.1007/s10142-023-01068-2
Publikováno v:
Ear, nose,throat journal.
Gout nodules (tophi) are formed by a chronic inflammatory reaction in tissues resulting in deposition of urate crystals. They are commonly seen in joints and surrounding tissues, subcutaneous tissues, as well as the pinna and kidney, and are characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062f2391127f2b5cd99ae9e9c052210d
https://pubmed.ncbi.nlm.nih.gov/36420695
https://pubmed.ncbi.nlm.nih.gov/36420695
Autor:
Biao Ruan, Yanan He, Yingwei Chen, Eun Jung Choi, Yihong Chen, Dana Motabar, Tsega Solomon, Richard Simmerman, Thomas Kauffman, D. Travis Gallagher, John Orban, Philip N. Bryan
To better understand how amino acid sequence encodes protein structure, we engineered mutational pathways that connect three common folds (3α, β−grasp, and α/β−plait). The structures of proteins at high sequence-identity intersections in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21123bc33300bf0b0dab18beeddcd92
https://doi.org/10.1101/2022.10.26.513944
https://doi.org/10.1101/2022.10.26.513944
Autor:
John Orban, Yihong Chen, Yanan He, David J. Weber, Eun Jung Choi, Raquel Godoy-Ruiz, Biao Ruan, D. Travis Gallagher, Melani Solomon, Thomas R. Fuerst, Ruixue Wang, David A. Rozak, Gregory S. Custer, Philip N. Bryan, Harlan King, Silvia Muro, Eric A. Toth, Yingwei Chen, Richard Simmerman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology
Communications Biology
We describe the design, kinetic properties, and structures of engineered subtilisin proteases that degrade the active form of RAS by cleaving a conserved sequence in switch 2. RAS is a signaling protein that, when mutated, drives a third of human can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768ae163ddb6ebc0c904ea01793832d2
https://doaj.org/article/742c1a3e0584400b8b631c6e4a1b0ff6
https://doaj.org/article/742c1a3e0584400b8b631c6e4a1b0ff6
Publikováno v:
Genetic Testing and Molecular Biomarkers. 24:249-255
Aims: To determine the clinical characteristics and genetic cause of Waardenburg syndrome type 1 (WS1) in a Chinese family. Materials and Methods: Evaluations, including history, clinical features, and audiological tests, were performed on the proban
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36f7d4dfc4636478b8505353589086bd
https://doi.org/10.1089/gtmb.2019.0231
https://doi.org/10.1089/gtmb.2019.0231