Exploiting a Phage-Bacterium Interaction System as a Molecular Switch to Decipher Macromolecular Interactions in the Living Cell

Autor: Éva Viola Surányi, Rita Hírmondó, Kinga Nyíri, Szilvia Tarjányi, Bianka Kőhegyi, Judit Tóth, Beáta G. Vértessy

Publikováno v: Viruses, Vol 10, Iss 4, p 168 (2018)

Pathogenicity islands of Staphylococcus aureus are under the strong control of helper phages, where regulation is communicated at the gene expression level via a family of specific repressor proteins. The repressor proteins are crucial to phage-host

Externí odkaz: https://doaj.org/article/c2665943ec8c40499583152a2c825787

Structural model of human dUTPase in complex with a novel proteinaceous inhibitor

Autor: Judit Matejka, Antoni J. Borysik, Oliver Ozohanics, Kinga Nyíri, M.J. Harris, Károly Vékey, Dmitri I. Svergun, Gergely N. Nagy, Haydyn D. T. Mertens, Bianka Kőhegyi, Judit Szabó, Beáta G. Vértessy, Veronika Papp-Kádár, Borbála Tihanyi, Veronika Németh-Pongrácz

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific reports 8(1), 4326 (2018). doi:10.1038/s41598-018-22145-8
Nyíri, K, Mertens, H D T, Tihanyi, B, Nagy, G N, Kohegyi, B, Matejka, J, Harris, M J, Szabó, J E, Papp-Kádár, V, Németh-Pongrácz, V, Ozohanics, O, Vékey, K, Svergun, D I, Borysik, A J & Vértessy, B G 2018, ' Structural model of human dUTPase in complex with a novel proteinaceous inhibitor ', Scientific Reports, vol. 8, no. 1, 4326 . https://doi.org/10.1038/s41598-018-22145-8

Human deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase), essential for DNA integrity, acts as a survival factor for tumor cells and is a target for cancer chemotherapy. Here we report that the Staphylococcal repressor protein StlSaPIBov1 (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e997fa88f0e1b8890b70e198e329afe
https://doi.org/10.1038/s41598-018-22145-8