Hof1 and Rvs167 have redundant roles in actomyosin ring function during cytokinesis in budding yeast.

Autor: Pedro Junior Nkosi, Bianca-Sabrina Targosz, Karim Labib, Alberto Sanchez-Diaz

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e57846 (2013)

The Hof1 protein (Homologue of Fifteen) regulates formation of the primary septum during cytokinesis in the budding yeast Saccharomyces cerevisiae, whereas the orthologous Cdc15 protein in fission yeast regulates the actomyosin ring by using its F-BA

Externí odkaz: https://doaj.org/article/f70c7c38746c421caa38601e36738bb8

Cross Talk Networks of Mammalian Target of Rapamycin Signaling With the Ubiquitin Proteasome System and Their Clinical Implications in Multiple Myeloma

Autor: Bianca-Sabrina Targosz, Florian Bassermann, Ruth Eichner, Vanesa Fernández-Sáiz

Publikováno v: International Review of Cell and Molecular Biology volume 343
International Review of Cell and Molecular Biology ISBN: 9780128167038
International Review of Cell and Molecular Biology

Multiple myeloma (MM) is the second most common hematological malignancy and results from the clonal amplification of plasma cells. Despite recent advances in treatment, MM remains incurable with a median survival time of only 5–6 years, thus neces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a8ac5bf4df0d367a21340b2c241db1

Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity

Autor: Anne-Kathrin Garz, Ulrich Germing, Frauke van Bebber, Martina Rudelius, Katharina Götze, Ruth Eichner, Anna-Maria Knorn, Vanesa Fernández-Sáiz, Bettina Schmid, Christian Haass, H. Einsele, Bernhard Kuster, Christian Peschel, Florian Bassermann, Stefan Knop, Jolanta Slawska, Simone Lemeer, Christian Langer, Bianca-Sabrina Targosz, Ulrich Keller, Laura Jacobs, Uwe Platzbecker, Michael Heider

Publikováno v: Nature Medicine, 22(7), 735. Nature Publishing Group
Nature medicine 22(7), 735-743 (2016). doi:10.1038/nm.4128

Immunomodulatory drugs (IMiDs), such as thalidomide and its derivatives lenalidomide and pomalidomide, are key treatment modalities for hematologic malignancies, particularly multiple myeloma (MM) and del(5q) myelodysplastic syndrome (MDS). Cereblon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517bd673db89b497ffcf5aa22ade20b5
https://dspace.library.uu.nl/handle/1874/344119

SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma

Autor: Anna-Maria Knorn, Bernhard Kuster, Clemens Reiter, Julia Slotta-Huspenina, Michele Pagano, Florian Bassermann, Bianca-Sabrina Targosz, Christian Peschel, Sonja Schroeder, Christian Langer, Lars Bullinger, Ruth Eichner, Vanesa Fernández-Sáiz, Julia Kurutz, Simone Lemeer

Publikováno v: Nature Cell Biology. 15:72-81

The Tel2 (also known as Telo2) and Tti1 proteins control the cellular abundance of mammalian PIKKs and are integral components of mTORC1 and mTORC2. Here we report that Tel2 and Tti1 are targeted for degradation within mTORC1 by the SCFFbxo9 ubiquiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39b335d09931aad34e73e826774563c
https://doi.org/10.1038/ncb2651

Hof1 and Rvs167 have redundant roles in actomyosin ring function during cytokinesis in budding yeast

Autor: Alberto Sanchez-Diaz, Pedro Junior Nkosi, Karim Labib, Bianca-Sabrina Targosz

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e57846 (2013)
PLoS ONE 8(2): e57846
Digital.CSIC. Repositorio Institucional del CSIC
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PLoS ONE

This is an open-access article distributed under the terms of the Creative Commons Attribution License.
The Hof1 protein (Homologue of Fifteen) regulates formation of the primary septum during cytokinesis in the budding yeast Saccharomyces cerev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32371a3287e0c6009073c1021a60bff
http://europepmc.org/articles/PMC3585203?pdf=render