Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Bianca Zingales"'
Autor:
Bianca Zingales, Andréa M. Macedo
Publikováno v:
Life, Vol 13, Iss 12, p 2339 (2023)
Trypanosoma cruzi, the protozoan causative of Chagas disease (ChD), exhibits striking genetic and phenotypic intraspecific diversity, along with ecoepidemiological complexity. Human-pathogen interactions lead to distinct clinical presentations of ChD
Externí odkaz:
https://doaj.org/article/98958e3b4af24526bd4863fbd0d815d1
Autor:
Maykon Tavares de Oliveira, Elena Sulleiro, Aroa Silgado Gimenez, Marta de Lana, Bianca Zingales, João Santana da Silva, J Antônio Marin-Neto, Israel Molina
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008311 (2020)
BACKGROUND:Trypanosoma cruzi has a high genetic and biological diversity and has been subdivided into seven genetic lineages, named TcI-TcVI and TcBat. DTUs TcI-TcII-TcV and TcVI are agents of ChD in different regions of Latin America. Due to populat
Externí odkaz:
https://doaj.org/article/235ec7639af3444988b320db91f7e5e1
A novel ABCG-like transporter of Trypanosoma cruzi is involved in natural resistance to benznidazole
Autor:
Bianca Zingales, Rafael Gomes Aquino Araujo, Margoth Moreno, Jaques Franco, Pedro Henrique Nascimento Aguiar, Solange Lessa Nunes, Marcelo Nunes Silva, Susan Ienne, Carlos Renato Machado, Adeilton Brandão
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 110, Iss 3, Pp 433-444 (2015)
Benznidazole (BZ) is one of the two drugs used for Chagas disease treatment. Nevertheless therapeutic failures of BZ have been reported, which were mostly attributed to variable drug susceptibility among Trypanosoma cruzi strains. ATP-binding cassett
Externí odkaz:
https://doaj.org/article/1ecbe905cd1f4d0b9ab5d59af41f693a
Autor:
Bianca Zingales, Michael A Miles, Carolina B Moraes, Alejandro Luquetti, Felipe Guhl, Alejandro G Schijman, Isabela Ribeiro
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 109, Iss 6, Pp 828-833 (2014)
This opinion piece presents an approach to standardisation of an important aspect of Chagas disease drug discovery and development: selecting Trypanosoma cruzi strains for in vitro screening. We discuss the rationale for strain selection representing
Externí odkaz:
https://doaj.org/article/0a9861aadc0b4e698760d43224f291f9
Autor:
Margoth Moreno, Daniella A D'ávila, Marcelo N Silva, Lúcia MC Galvão, Andrea M Macedo, Egler Chiari, Eliane D Gontijo, Bianca Zingales
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 105, Iss 7, Pp 918-924 (2010)
Therapeutic failure of benznidazole (BZ) is widely documented in Chagas disease and has been primarily associated with variations in the drug susceptibility of Trypanosoma cruzi strains. In humans, therapeutic success has been assessed by the negativ
Externí odkaz:
https://doaj.org/article/bed692bc0c74440f9f7a2a1468986aec
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 94, Pp 159-164 (1999)
Externí odkaz:
https://doaj.org/article/db44f274b572418b8bf684ebc93f2c04
Autor:
Eufrosina S Umezawa, Maria Aparecida Shikanai-Yasuda, Arthur Gruber, Vera L Pereira-Chioccola, Bianca Zingales
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 91, Iss 1, Pp 87-93 (1996)
Immunoglobulin G and M humoral response to recombinant protein B13 and glycoconjugate LPPG Trypanosoma cruzi defined antigens was evaluated by ELISA in 18 patients in the acute phase of Chagas disease, who were contaminated on the same occasion. LPPG
Externí odkaz:
https://doaj.org/article/f6dc28a56a4b4a24b227e9adf4c33b5a
Autor:
Marcia Duranti, Ludmila Camargo, Gabriel Victora, Barbara Ianni, Paula Buck, Charles Mady, Jorge Kalil, Bianca Zingales, Edecio Cunha-Neto
Publikováno v:
Journal of Parasitology Research, Vol 2012 (2012)
The tandemly repetitive Trypanosoma cruzi B13 protein is an immunodominant antigen among Chagas disease patients. Such repetitive domains may behave as T-independent antigens. However, T cells can recognize B13 epitopes in an HLA class II-restricted
Externí odkaz:
https://doaj.org/article/7ef20d65aec24b4d9d723e91d8b51ebf
Publikováno v:
Revista do Instituto de Medicina Tropical de São Paulo, Vol 32, Iss 5, Pp 379-383 (1990)
A radioactive Western-blotting technique was developed by which the reactivity of Immunoglobulins (Igs) from different classes to both membrane radiolabelled and internal parasite antigens is simultaneously identified. The method includes radioiodina
Externí odkaz:
https://doaj.org/article/34c4a708e4eb45e3898a1f7d64aabad1
Autor:
Elizabeth N. De Gaspari, Eufrosina S. Umezawa, Bianca Zingales, Ana Maria S. Stolf, Walter Colli, Ises A. Abrahamsohn
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 85, Iss 3, Pp 261-270 (1990)
The specific antibody responses were compared among susceptible (A/Sn), moderately susceptible (Balb/c) and resistant (C57 BL/lOJ) mice infected with Trypanosoma cruzi (Y strain). Sera obtained during the second week of infection recognized a surface
Externí odkaz:
https://doaj.org/article/5ef49cb89b444563ae7720f9fc36c1e1