Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Bianca Van Broeck"'
Autor:
Dina Rodrigues Martins, Fern Sha, Wim Van der Elst, Pei-Yu Shih, Jens Devoght, Kristof Van Kolen, Marc Mercken, Bianca Van Broeck, Paul Declerck, Clara Theunis
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101158- (2023)
Over the last decade, there has been a growing interest in intrabodies and their therapeutic potential. Intrabodies are antibody fragments that are expressed inside a cell to target intracellular antigens. In the context of intracellular protein misf
Externí odkaz:
https://doaj.org/article/e45647860e164d9dae0413302661ce85
Autor:
Jonathan Janssens, Bart Hermans, Marc Vandermeeren, Erio Barale-Thomas, Marianne Borgers, Roland Willems, Greet Meulders, Cindy Wintmolders, Dries Van den Bulck, Astrid Bottelbergs, Luc Ver Donck, Peter Larsen, Dieder Moechars, Wilson Edwards, Marc Mercken, Bianca Van Broeck
Publikováno v:
Neurobiology of Disease, Vol 154, Iss , Pp 105365- (2021)
The imbalance between production and clearance of amyloid β (Aβ) peptides and their resulting accumulation in the brain is an early and crucial step in the pathogenesis of Alzheimer's disease (AD). Therefore, Aβ is strongly positioned as a promisi
Externí odkaz:
https://doaj.org/article/7f712f2755314a818f17894b585c61e7
Autor:
Jelle Praet, Nikolay V. Manyakov, Leacky Muchene, Zhenhua Mai, Vasilis Terzopoulos, Steve de Backer, An Torremans, Pieter-Jan Guns, Tom Van De Casteele, Astrid Bottelbergs, Bianca Van Broeck, Jan Sijbers, Dirk Smeets, Ziv Shkedy, Luc Bijnens, Darrel J. Pemberton, Mark E. Schmidt, Annemie Van der Linden, Marleen Verhoye
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-16 (2018)
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in the elderly population. In this study, we used the APP/PS1 transgenic mouse model to explore the feasibility of using
Externí odkaz:
https://doaj.org/article/2e0e17af4d50440b83a9140322f6cfeb
Autor:
Bianca Van Broeck, Jens Fissers, Darrel J. Pemberton, Thomas De Vijlder, Leonie Wyffels, Marc Mercken
Publikováno v:
Rapid communications in mass spectrometry
Rationale: Immuno-PET imaging may prove to be a diagnostic and progression/intervention biomarker for Alzheimer's disease (AD) with improved sensitivity and specificity. Immuno-PET imaging is based on the coupling of an antibody with a chelator that
Autor:
Astrid Bottelbergs, Bart Hermans, Nikolay V. Manyakov, Cindy Wintmolders, M. Borgers, Gethin Davies, Detlef Balschun, Marijke De Bock, Wilhelmus Drinkenburg, Bianca Van Broeck, Clara Theunis, Sofia Jacob
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific Reports, 9:16363. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific Reports, 9:16363. Nature Publishing Group
Multiple animal models have been created to gain insight into Alzheimer’s disease (AD) pathology. Among the most commonly used models are transgenic mice overexpressing human amyloid precursor protein (APP) with mutations linked to familial AD, res
Autor:
Astrid Bottelbergs, Xavier Langlois, Ann Marie Waldron, Steven Staelens, Bianca Van Broeck, Jeroen Verhaeghe, Leonie Wyffels, Steven Deleye, Sigrid Stroobants, Mark E. Schmidt
Publikováno v:
The Journal of nuclear medicine
In this study, we investigated the effects of chronic administration of an inhibitor of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) on Alzheimer-related pathology by multitracer PET imaging in transgenic APPPS1-21 (TG) mice. Met
Autor:
Jennifer Bogert, Johannes Streffer, Bart De Strooper, John Slemmon, Soraia Barão Lourenco Barao, Luc Van Nueten, Bianca Van Broeck, Marc Mercken, Leslie M. Shaw, Ina Tesseur, Katja De Waepenaert, Dieder Moechars, Sebastiaan Engelborghs, Luc Tritsmans, Maarten Timmers
Publikováno v:
Journal of Alzheimer's Disease
Journal of Alzheimer's disease
Journal of Alzheimer's disease
The β-site amyloid-β protein precursor (AβPP) cleaving enzyme-1 (BACE1) is the rate limiting enzyme in the generation of amyloid-β peptide (Aβ) from AβPP, one of the major pathways in Alzheimers disease (AD) pathology. Increased BACE1 levels an
Autor:
Marc Mercken, John Slemmon, Luc Van Nueten, Hans Stieltjes, Bianca Van Broeck, Enchi Liu, John Kemp, Maarten Timmers, Vikash K. Sinha, Jennifer Bogert, Luc Tritsmans, Katja De Waepenaert, Steven Ramael, Dieder Moechars, Sebastiaan Engelborghs, Alberto Russu, Leslie M. Shaw, Johannes Streffer
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Objectives Safety, tolerability, pharmacokinetics, and pharmacodynamics of a novel β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, JNJ-54861911, were assessed after single and multiple dosing in healthy participants. Methods Tw
Autor:
Pieter-Jan Guns, Dirk Smeets, Tom Van De Casteele, Astrid Bottelbergs, Ziv Shkedy, Marleen Verhoye, Mark E. Schmidt, Leacky Muchene, Jelle Praet, Darrel J. Pemberton, Luc Bijnens, Annemie Van der Linden, Nikolay V. Manyakov, Steve De Backer, Vasilis Terzopoulos, Jan Sijbers, Zhenhua Mai, An Torremans, Bianca Van Broeck
Publikováno v:
Alzheimer's Research & Therapy
Alzheimer's research & therapy
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-16 (2018)
Alzheimer's research & therapy
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-16 (2018)
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in the elderly population. In this study, we used the APP/PS1 transgenic mouse model to explore the feasibility of using diffusion
Autor:
Thomas, De Vijlder, Jens, Fissers, Bianca, Van Broeck, Leonie, Wyffels, Marc, Mercken, Darrel J, Pemberton
Publikováno v:
Rapid communications in mass spectrometry : RCM.
Immuno-PET imaging may prove to be a diagnostic and progression/intervention biomarker for Alzheimer's disease (AD) with improved sensitivity and specificity. Immuno-PET imaging is based on the coupling of an antibody with a chelator that captures a