The role of regulatory B cells in immune regulation and childhood allergic asthma

Autor: Caroline Vanessa Kliem, Bianca Schaub

Publikováno v: Molecular and Cellular Pediatrics, Vol 11, Iss 1, Pp 1-9 (2024)

Abstract Background As the most common chronic disease in childhood, asthma displays a major public health problem worldwide with the incidence of those affected rising. As there is currently no cure for allergic asthma, it is mandatory to get a bett

Externí odkaz: https://doaj.org/article/757c102797e74ce2a9363094049bf959

Rural environment reduces allergic inflammation by modulating the gut microbiota

Autor: Zhaowei Yang, Zhong Chen, Xinliu Lin, Siyang Yao, Mo Xian, Xiaoping Ning, Wanyi Fu, Mei Jiang, Naijian Li, Xiaojun Xiao, Mulin Feng, Zexuan Lian, Wenqing Yang, Xia Ren, Zhenyu Zheng, Jiefeng Zhao, Nili Wei, Wenju Lu, Marjut Roponen, Bianca Schaub, Gary W. K. Wong, Zhong Su, Charles Wang, Jing Li

Publikováno v: Gut Microbes, Vol 14, Iss 1 (2022)

Rural environments and microbiota are linked to a reduction in the prevalence of allergies. However, the mechanism underlying the reduced allergies modulated by rural residency is unclear. Here, we assessed gut bacterial composition and metagenomics

Externí odkaz: https://doaj.org/article/a8f7723ef7c34897a06fb51da0657190

In vitro neutrophil migration is associated with inhaled corticosteroid treatment and serum cytokines in pediatric asthma

Autor: Solveig Lemmel, Markus Weckmann, Anna Wohlers, Adan Chari Jirmo, Ruth Grychtol, Isabell Ricklefs, Gyde Nissen, Anna Bachmann, Shantanu Singh, Juan Caicedo, Thomas Bahmer, Gesine Hansen, Erika Von Mutius, Klaus F. Rabe, Oliver Fuchs, Anna-Maria Dittrich, Bianca Schaub, Christine Happle, Anne E. Carpenter, Matthias Volkmar Kopp, Tim Becker, the ALLIANCE Study Group as part of the German Centre for Lung Research (DZL), Mustafa Abdo, Miguel Alcazar, Mira Berbig, Heike Biller, Xenia Bovermann, Folke Brinkmann, Mifflin-Rae Calveron, David S. DeLuca, Gesa Diekmann, Christian Dopfer, Markus Ege, Svenja Foth, Svenja Gaedcke, Karoline I. Gaede, Anika Habener, Christian Herzmann, Alexander Hose, Sabina Illi, Anne-Marie Kirsten, Naschla Kohistani-Greif, Inke R. König, Silke Van Koningsbruggen-Rietschel, Matthias V. Kopp, Johanna Kurz, Katja Landgraf-Rauf, Kristina Laubhahn, Lena Liboschik, Claudia Liebl, Berrit Liselotte Husstedt, Bin Liu, Nicole Maison, Aydin Malik, Carola Marzi, Meike Meyer, Catharina Nitsche, Frauke Pedersen, Mareike Price, Harald Renz, Ernst Rietschel, Barbara Roesler, Christina Schauberger, Tom Schildberg, Carsten Schmidt-Weber, Nicolaus Schwerk, Chrysanthi Skevaki, Alena Steinmetz, Laila Sultansei, Marlen Szewczyk, Dominik Thiele, Vera Veith, Gesche Voigt, Benjamin Waschki, Henrik Watz, Stefanie Weber, Nils Welchering, Esther Zeitlmann, Ulrich Zissler

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Background: Different asthma phenotypes are driven by molecular endotypes. A Th1-high phenotype is linked to severe, therapy-refractory asthma, subclinical infections and neutrophil inflammation. Previously, we found neutrophil granulocytes (NGs) fro

Externí odkaz: https://doaj.org/article/fc7e3e168608484cb6c82625730f72c5

Timing of Blood Sample Processing Affects the Transcriptomic and Epigenomic Profiles in CD4+ T-cells of Atopic Subjects

Autor: Fahd Alhamdan, Kristina Laubhahn, Christine Happle, Anika Habener, Adan C. Jirmo, Clemens Thölken, Raffaele Conca, Ho-Ryun Chung, Gesine Hansen, Daniel P. Potaczek, Bianca Schaub, Ruth Grychtol, Holger Garn

Publikováno v: Cells, Vol 11, Iss 19, p 2958 (2022)

Optimal pre-analytical conditions for blood sample processing and isolation of selected cell populations for subsequent transcriptomic and epigenomic studies are required to obtain robust and reproducible results. This pilot study was conducted to in

Externí odkaz: https://doaj.org/article/6bb792f3ee8248c78b423e4beba9dd68

Third Follow-Up of the Study on Occupational Allergy Risks (SOLAR III) in Germany: Design, Methods, and Initial Data Analysis

Autor: Felix Forster, Sylvia Kreißl, Laura Wengenroth, Christian Vogelberg, Erika von Mutius, Bianca Schaub, Dennis Nowak, Tobias Weinmann, Katja Radon, Jessica Gerlich

Publikováno v: Frontiers in Public Health, Vol 9 (2021)

Introduction: Asthma and allergies are complex diseases affected by genetic and environmental factors, such as occupational and psychosocial factors, as well as interactions between them. Although childhood is a critical phase in the development of a

Externí odkaz: https://doaj.org/article/5ecd6fdb10654879926f2ce77f3e9206