Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer

Autor: Michela Masetti, Roberta Carriero, Federica Portale, Giulia Marelli, Nicolò Morina, Marta Pandini, Marta Iovino, Bianca Partini, Marco Erreni, Andrea Ponzetta, Elena Magrini, Piergiuseppe Colombo, Grazia Elefante, Federico Simone Colombo, Joke M.M. den Haan, Clelia Peano, Javier Cibella, Alberto Termanini, Paolo Kunderfranco, Jolanda Brummelman, Matthew Wai Heng Chung, Massimo Lazzeri, Rodolfo Hurle, Paolo Casale, Enrico Lugli, Ronald A. DePinho, Subhankar Mukhopadhyay, Siamon Gordon, Diletta Di Mitri

Publikováno v: Journal of Experimental Medicine, 219(2):e20210564. Rockefeller University Press
Masetti, M, Carriero, R, Portale, F, Marelli, G, Morina, N, Pandini, M, Iovino, M, Partini, B, Erreni, M, Ponzetta, A, Magrini, E, Colombo, P, Elefante, G, Simone Colombo, F, den Haan, J M M, Peano, C, Cibella, J, Termanini, A, Kunderfranco, P, Brummelman, J, Chung, M W H, Lazzeri, M, Hurle, R, Casale, P, Lugli, E, DePinho, R A, Mukhopadhyay, S, Gordon, S & Di Mitri, D 2021, ' Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer ', Journal of Experimental Medicine, vol. 219, no. 2, e20210564 . https://doi.org/10.1084/jem.20210564

Tumor-associated macrophages (TAMs) are correlated with the progression of prostatic adenocarcinoma (PCa). The mechanistic basis of this correlation and therapeutic strategies to target TAMs in PCa remain poorly defined. Here, single-cell RNA sequenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037a35db79fb52deedf5e3a94f8ad206
https://doi.org/10.1084/jem.20210564

High-dimensional single cell-based immune profiling of the tumor immune microenvironment in prostate cancer

Autor: Diletta Di Mitri, Clelia Peano, Giorgio Guazzoni, Maria Grazia Elefante, Paolo Casale, Michela Masetti, Nicolò Buffi, Massimo Lazzeri, Federica Portale, Alberto Saita, Nicolò Morina, Andrea Ponzetta, Bianca Partini, Giovanni Lughezzani, Paolo Kunderfranco, Piergiuseppe Colombo, Javier Cibella, Roberta Carriero

Publikováno v: Journal of Clinical Oncology. 38:376-376

376 Background: Genetic lesions that drive prostate cancer (PCa) development are able to modify the immune response and tumor infiltrating immune subsets, resulting in tumor progression. We investigated the profile of the immune microenvironment in P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::beda128981e4a615921ad3a3d7310efc
https://doi.org/10.1200/jco.2020.38.6_suppl.376