Výsledky vyhledávání - "Bianca M. Zani"

Biological rationale for targeting MEK/ERK pathways in anti-cancer therapy and to potentiate tumour responses to radiation

Autor: Francesco Marampon, Bianca M. Zani, Carmela Ciccarelli

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 10, p 2530 (2019)

ERK1 and ERK2 (ERKs), two extracellular regulated kinases (ERK1/2), are evolutionary-conserved and ubiquitous serine-threonine kinases involved in regulating cell signalling in normal and pathological tissues. The expression levels of these kinases a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5bd9a6874923acef9b6f50cee20b54f
http://hdl.handle.net/11697/139650

Zobrazit plný text záznamu

Testosterone-mediated activation of androgenic signalling sustains in vitro the transformed and radioresistant phenotype of rhabdomyosarcoma cell lines

Publikováno v: Journal of endocrinological investigation. 42(2)

Rhabdomyosarcoma (RMS), the most common soft-tissue sarcoma in childhood, rarely affects adults, preferring male. RMS expresses the receptor for androgen (AR) and responds to androgen; however, the molecular action of androgens on RMS is unknown. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57eb5418f2984e2f4c0c7ea9c87e9020
https://pubmed.ncbi.nlm.nih.gov/29790086

Zobrazit plný text záznamu

Disruption of MEK/ERK/c-Myc signaling radiosensitizes prostate cancer cells in vitro and in vivo

Autor: Bianca M. Zani, Claudio Festuccia, Andrea Del Fattore, Daniela Musio, Paolo Berardinelli, Marina Bouché, Francesca De Felice, Giovanni Luca Gravina, Annunziata Mauro, Vincenzo Tombolini, Francesco Marampon, Agnese Di Rocco, Carmela Ciccarelli

Prostate cancer (PCa) cell radioresistance causes the failure of radiation therapy (RT) in localized or locally advanced disease. The aberrant accumulation of c-Myc oncoprotein, known to promote PCa onset and progression, may be due to the control of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d51eb9327d2bd98d37668e05892c87e
http://hdl.handle.net/11573/1127783

Zobrazit plný text záznamu

Vitamin D Protects Human Endothelial Cells from H2O2 Oxidant Injury Through the Mek/Erk-Sirt1 Axis Activation

Autor: Giovanni Luca Gravina, Francesco Marampon, Bianca M. Zani, Giuliana Properzi, L. Polidoro, Luca Scarsella, Claudio Festuccia, E. Di Cesare, Claudio Ferri, Carmela Ciccarelli

Publikováno v: Journal of Cardiovascular Translational Research. 6:221-231

Endothelium homeostasis alterations govern the pathogenesis of cardiovascular diseases. Several studies show that vitamins anti-oxidant proprieties rescue the endothelial functions adversely affected by oxidative stress in several diseases. We invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::736115a4823dacd5a942b1b9f5893ab4
https://doi.org/10.1007/s12265-012-9436-x

Zobrazit plný text záznamu

MEK/ERK inhibitor U0126 affects in vitro and in vivo growth of embryonal rhabdomyosarcoma

Autor: Francesco Marampon, Bianca M. Zani, Ada Sacchi, Agnese Di Rocco, Gianluca Bossi, Richard G. Pestell, Carmela Ciccarelli

Publikováno v: Molecular Cancer Therapeutics. 8:543-551

We reported previously that the disruption of c-Myc through mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) inhibition blocks the expression of the transformed phenotype in the embryonal rhabdomyosarcoma (ERM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e260458c9f0b4d0716bb721b2400b2
https://doi.org/10.1158/1535-7163.mct-08-0570

Zobrazit plný text záznamu

Nerve Growth Factor Regulation of Cyclin D1 in PC12 Cells through a p21RASExtracellular Signal-regulated Kinase Pathway Requires Cooperative Interactions between Sp1 and Nuclear Factor-κB

Autor: Vladimir M. Popov, Richard T. Lee, Maofu Fu, Mathew C. Casimiro, Michael J. Powell, Jaime Lindsay, Francesco Marampon, Genichi Watanabe, Richard G. Pestell, Bianca M. Zani, Carmela Ciccarelli

Publikováno v: Molecular Biology of the Cell. 19:2566-2578

The PC12 pheochromocytoma cell line responds to nerve growth factor (NGF) by exiting from the cell cycle and differentiating to induce extending neurites. Cyclin D1 is an important regulator of G1/S phase cell cycle progression, and it is known to pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41da60a879c0ad179228d41f18b8e021
https://doi.org/10.1091/mbc.e06-12-1110

Zobrazit plný text záznamu

ROCK2 and Its Alternatively Spliced Isoform ROCK2m Positively Control the Maturation of the Myogenic Program

Autor: Michele Pelosi, Antonio Musarò, Nadia Rosenthal, Shuh Narumiya, Viviana Caputo, Sabrina Prudente, Valeria Berno, Luciano Cianetti, Shin W Kang, Bianca M. Zani, Francesco Marampon, Emerald Perlas

Publikováno v: Molecular and Cellular Biology. 27:6163-6176

Signal transduction cascades involving Rho-associated kinases (ROCK), the serine/threonine kinases downstream effectors of Rho, have been implicated in the regulation of diverse cellular functions including cytoskeletal organization, cell size contro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d589d0ea0bbea59b3be3d4ff5f1c2bda
https://doi.org/10.1128/mcb.01735-06

Zobrazit plný text záznamu

Characterization of the osteoblast-like cell phenotype under microgravity conditions in the NASA-approved rotating wall vessel bioreactor (RWV)

Autor: Anna Taranta, Anna Teti, Silvia Migliaccio, Nadia Rucci, Bianca M. Zani

Publikováno v: Journal of Cellular Biochemistry. 85:167-179

Weightlessness induces bone loss in humans and animal models. We employed the NASA-approved Rotating Wall Vessel bioreactor (RWV) to develop osteoblast-like cell cultures under microgravity and evaluate osteoblast phenotype and cell function. Rat ost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58d2c08da0c5deded27e370d2b995b92
https://doi.org/10.1002/jcb.10120

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání