Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation

Autor: Marit Wiersma, Denise M.S. van Marion, Rob C.I. Wüst, Riekelt H. Houtkooper, Deli Zhang, Natasja M.S. de Groot, Robert H. Henning, Bianca J.J.M. Brundel

Publikováno v: Cells, Vol 8, Iss 10, p 1202 (2019)

Atrial fibrillation (AF), the most common progressive tachyarrhythmia, results in structural remodeling which impairs electrical activation of the atria, rendering them increasingly permissive to the arrhythmia. Previously, we reported on endoplasmic

Externí odkaz: https://doaj.org/article/4c29942c62ba46af966b32272cac56d1

COVID-19-related cardiac complications from clinical evidences to basic mechanisms: opinion paper of the ESC Working Group on Cellular Biology of the Heart

Autor: Can Gollmann-Tepeköylü, Sabine Steffens, Ivan Tancevski, Sean M. Davidson, Maurizio Pesce, Joost P.G. Sluijter, Piergiuseppe Agostoni, Raffaele De Caterina, Sandrine Lecour, Bianca J.J.M. Brundel, Jean-Sébastien Hulot, Cinzia Perrino, Péter Ferdinandy, Hans-Erik Bøtker, Henrique Girão, Mariann Gyöngyösi, Rainer Schulz, Rosalinda Madonna, Carsten Tschöpe, Sophie Van Linthout

Publikováno v: Pesce, M, Agostoni, P, Bøtker, H-E, Brundel, B, Davidson, S M, De Caterina, R, Ferdinandy, P, Girao, H, Gyöngyösi, M, Hulot, J-S, Lecour, S, Perrino, C, Schulz, R, Sluijter, J P G, Steffens, S, Tancevski, I, Gollmann-Tepeköylü, C, Tschöpe, C, van Linthout, S & Madonna, R 2021, ' COVID-19 related cardiac complications from clinical evidences to basic mechanisms : Opinion paper of the ESC Working Group on Cellular Biology of the Heart ', Cardiovascular Research, vol. 117, no. 10, pp. 2148-2160 . https://doi.org/10.1093/cvr/cvab201
Cardiovascular Research
Cardiovascular Research, 2021, 117 (10), pp.2148-2160. ⟨10.1093/cvr/cvab201⟩

The pandemic of coronavirus disease (COVID)-19 is a global threat, causing high mortality, especially in the elderly. The main symptoms and the primary cause of death are related to interstitial pneumonia. Viral entry also into myocardial cells mainl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c715ba6bc50d84346615f6092b7532c6
https://doi.org/10.1093/cvr/cvab201

The effect of tropomyosin variants on cardiomyocyte function and structure that underlie different clinical cardiomyopathy phenotypes

Autor: Maarten P. van den Berg, Karin Y. van Spaendonck-Zwarts, Jan D. H. Jongbloed, Aryan Vink, Ludolf G. Boven, Bianca J.J.M. Brundel, Gideon J. du Marchie Sarvaas, Larissa M. Dorsch, Jolanda van der Velden, Albert J. H. Suurmeijer, Paul A. van der Zwaag, Diederik W. D. Kuster

Publikováno v: International Journal of Cardiology, 323(1), 251-258. Elsevier Ireland Ltd
Dorsch, L M, Kuster, D W D, Jongbloed, J D H, Boven, L G, van Spaendonck-Zwarts, K Y, Suurmeijer, A J H, Vink, A, du Marchie Sarvaas, G J, van den Berg, M P, van der Velden, J, Brundel, B J J M & van der Zwaag, P A 2021, ' The effect of tropomyosin variants on cardiomyocyte function and structure that underlie different clinical cardiomyopathy phenotypes ', International Journal of Cardiology, vol. 323, no. 1, pp. 251-258 . https://doi.org/10.1016/j.ijcard.2020.08.101
International Journal of Cardiology, 323, 251-258. ELSEVIER IRELAND LTD
International journal of cardiology, 323, 251-258. Elsevier Ireland Ltd

Background - Variants within the alpha-tropomyosin gene (TPM1) cause dominantly inherited cardiomyopathies, including dilated (DCM), hypertrophic (HCM) and restrictive (RCM) cardiomyopathy. Here we investigated whether TPM1 variants observed in DCM a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d7dc57073de47ab56ff7d1d3f38eb12
https://doi.org/10.1016/j.ijcard.2020.08.101

Atrial fibrillation fingerprinting; spotting bio-electrical markers to early recognize atrial fibrillation by the use of a bottom-up approach (AFFIP): Rationale and design

Autor: Ad J.J.C. Bogers, Bianca J.J.M. Brundel, Maarten C. Roos-Serote, Paul Knops, Kennedy S. Ramos, Natasja M.S. de Groot, Roeliene Starreveld

Publikováno v: Clinical Cardiology, 43(6), 546-552. Wiley-Blackwell
Clinical Cardiology
Clinical cardiology, 43(6), 546-552. Wiley-Blackwell
Starreveld, R, Knops, P, Silva Ramos, K, Roos-Serote, M C, Bogers, A J J C, Brundel, B J J M & de Groot, N M S 2020, ' Atrial fibrillation fingerprinting; spotting bio-electrical markers to early recognize atrial fibrillation by the use of a bottom-up approach (AFFIP) : Rationale and design ', Clinical cardiology, vol. 43, no. 6, pp. 546-552 . https://doi.org/10.1002/clc.23370

Background: The exact pathophysiology of atrial fibrillation (AF) remains incompletely understood and treatment of AF is associated with high recurrence rates. Persistence of AF is rooted in the presence of electropathology, defined as complex electr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b57010bc86f14f98dcad4f97965908
https://doi.org/10.1002/clc.23370

The Role of Mitochondrial Dysfunction in Atrial Fibrillation: Translation to Druggable Target and Biomarker Discovery

Autor: Leonoor F. J. M. Wijdeveld, Bianca J.J.M. Brundel, Natasja M.S. de Groot, Lisa Pool

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 8463, p 8463 (2021)
International Journal of Molecular Sciences

Atrial fibrillation (AF) is the most prevalent and progressive cardiac arrhythmia worldwide and is associated with serious complications such as heart failure and ischemic stroke. Current treatment modalities attenuate AF symptoms and are only modera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9285d8dc00ae8c6d8a47c2eb4de276
https://www.mdpi.com/1422-0067/22/16/8463