Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Bianca J. Lam"'
1
Discovery of small molecules that target a tertiary-structured RNA
Autor: Elena Menichelli, Bianca J. Lam, Yu Wang, Vivian S. Wang, Jennifer Shaffer, Katrina F. Tjhung, Badry Bursulaya, Truc Ngoc Nguyen, Todd Vo, Phillip B Alper, Christopher S McAllister, David H. Jones, Glen Spraggon, Pierre-Yves Michellys, John Joslin, Gerald F. Joyce, Jeff Rogers
Publikováno v: Proceedings of the National Academy of Sciences. 119
There is growing interest in therapeutic intervention that targets disease-relevant RNAs using small molecules. While there have been some successes in RNA-targeted small-molecule discovery, a deeper understanding of structure–activity relationship
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b63539b3423ca34c26d9030ee5bf0b
https://doi.org/10.1073/pnas.2213117119
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2
Retention of spliceosomal components along ligated exons ensures efficient removal of multiple introns
Autor: Bianca J. Lam, Klemens J. Hertel, Tara L. Crabb
Publikováno v: Crabb, TL; Lam, BJ; & Hertel, KJ. (2010). Retention of spliceosomal components along ligated exons ensures efficient removal of multiple introns. RNA, 16(9), 1786-1796. doi: 10.1261/rna.2186510. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2xg3x47h
The majority of mammalian pre-mRNAs contains multiple introns that are excised prior to export and translation. After intron excision, ligated exon intermediates participate in subsequent intron excisions. However, exon ligation generates an exon of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64a877e143b813c9b9cb683e9ef9928
https://doi.org/10.1261/rna.2186510
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3
Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA
Autor: Bianca J. Lam, Gerald F. Joyce
Publikováno v: Nature biotechnology
RNA enzymes have been developed that undergo self-sustained replication at a constant temperature in the absence of proteins1. These RNA molecules amplify exponentially through a cross-replicative process, whereby two enzymes catalyze each other’s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d5bd100d415d4b7889d3e8442d0a0a
https://doi.org/10.1038/nbt.1528
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4
An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification
Autor: Gerald F. Joyce, Bianca J. Lam
Publikováno v: Journal of the American Chemical Society. 133(9)
A system was devised that enables quantitative, ligand-dependent exponential amplification for various ligands that can be recognized by an RNA aptamer. The aptamer is linked to an RNA enzyme that catalyzes the joining of two oligonucleotide substrat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d443e38a3bcc42c96bf10680763f3e18
https://pubmed.ncbi.nlm.nih.gov/21322594
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6
The architecture of pre-mRNAs affects mechanisms of splice-site pairing
Autor: She-pin Hung, Kristi L. Fox-Walsh, Bianca J. Lam, Pierre Baldi, Klemens J. Hertel, Yimeng Dou
Publikováno v: Fox-Walsh, KL; Dou, Y; Lam, BJ; Hung, SP; Baldi, PF; & Hertel, KJ. (2005). The architecture of pre-mRNAs affects mechanisms of splice-site pairing. Proceedings of the National Academy of Sciences of the United States of America, 102(45), 16176-16181. doi: 10.1073/pnas.0508489102. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2jq8q83x
Fox-Walsh, KL; Dou, YM; Lam, BJ; Hung, SP; Baldi, PF; & Hertel, KJ. (2005). The architecture of pre-mRNAs affects mechanisms of splice-site pairing. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(45), 16176-16181. doi: 10.1073/pnas.050849102. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3b12w5ff
The exon/intron architecture of genes determines whether components of the spliceosome recognize splice sites across the intron or across the exon. Using in vitro splicing assays, we demonstrate that splice-site recognition across introns ceases when
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6afc79f9a5ed1379262a5be181fb0ab
http://www.escholarship.org/uc/item/2jq8q83x
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7
Analyzing mechanisms of alternative pre-mRNA splicing using in vitro splicing assays
Autor: Martin J. Hicks, Bianca J. Lam, Klemens J. Hertel
Publikováno v: Hicks, MJ; Lam, BJ; & Hertel, KJ. (2005). Analyzing mechanisms of alternative pre-mRNA splicing using in vitro splicing assays. Methods, 37(4), 306-313. doi: 10.1016/j.ymeth.2005.07.012. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9nm9c7g7
The development of in vitro assays to analyze pre-mRNA splicing resulted in the discovery of many fundamental features characterizing splicing signals and the machinery that completes this process. Because in vitro assays can be manipulated by variou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b7b2195fe9258a532e9b9f639ba719
https://pubmed.ncbi.nlm.nih.gov/16314259
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8
Correction of SMN2 Pre-mRNA splicing by antisense U7 small nuclear RNAs
Autor: Till Geib, Sharlene R. Lim, Bianca J. Lam, Csilla Madocsai, Klemens J. Hertel
Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy. 12(6)
Mutations in one of the duplicated survival of motor neuron (SMN) genes lead to the progressive loss of motor neurons and subsequent development of spinal muscular atrophy (SMA), a common, and usually fatal, hereditary disease. Homozygous absence of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f7ac4a52089b1eb16b090e71e83e7d
https://pubmed.ncbi.nlm.nih.gov/16226920
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9
Enhancer-dependent 5'-splice site control of fruitless pre-mRNA splicing
Autor: Klemens J. Hertel, Arati Bakshi, Bianca J. Lam, F.Y. Ekinci, Brenton R. Graveley, Jenny Webb
Publikováno v: Lam, BJ; Bakshi, A; Ekinci, FY; Webb, J; Graveley, BR; & Hertel, KJ. (2003). Enhancer-dependent 5′-splice site control of fruitless pre-mRNA splicing. Journal of Biological Chemistry, 278(25), 22740-22747. doi: 10.1074/jbc.M301036200. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7nd909dq
The Drosophila fruitless (fru) gene encodes a transcription factor that essentially regulates all aspects of male courtship behavior. The use of alternative 5′-splice sites generates fru isoforms that determine gender-appropriate sexual behaviors.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764e6921644a566423b3bf636c58d1c4
https://pubmed.ncbi.nlm.nih.gov/12646561
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10
A general role for splicing enhancers in exon definition
Autor: Klemens J. Hertel, Bianca J. Lam
Publikováno v: Lam, BJ; & Hertel, KJ. (2002). A general role for splicing enhancers in exon definition. RNA, 8(10), 1233-1241. doi: 10.1017/S1355838202028030. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0m11s3mp
Exonic splicing enhancers (ESEs) facilitate exon definition by assisting in the recruitment of splicing factors to the adjacent intron. Here we demonstrate that suboptimal 59 and 39 splice sites are activated independently by ESEs when they are locat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753b6a3cd5014fe07792f4bcda98f4e8
https://pubmed.ncbi.nlm.nih.gov/12403462
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