Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Bianca J C van den Bosch"'
Autor:
N Chantal Peltenburg, Jörgen Bierau, Jaap A Bakker, Jolanda A Schippers, Selwyn H Lowe, Aimée D C Paulussen, Bianca J C van den Bosch, Mathie P G Leers, Bettina E Hansen, Annelies Verbon
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191069 (2018)
The purine analogues tenofovir and abacavir are precursors of potential substrates for the enzyme Inosine 5'-triphosphate pyrophosphohydrolase (ITPase). Here, we investigated the association of ITPase activity and ITPA genotype with the occurrence of
Externí odkaz:
https://doaj.org/article/830f603febab47ee816ac4e1156ed1d3
Autor:
Debbie S. Deben, Luc J. J. Derijks, Bianca J. C. van den Bosch, Rob H. Creemers, Annick van Nunen, Adriaan A. van Bodegraven, Dennis R. Wong
Publikováno v:
Metabolites, Vol 13, Iss 10, p 1054 (2023)
Tioguanine is metabolised by fewer enzymatic steps compared to azathioprine and mercaptopurine, without generating 6-methylmercaptopurine ribonucleotides. However, thiopurine S-methyl transferase (TPMT) plays a role in early toxicity in all thiopurin
Externí odkaz:
https://doaj.org/article/5fbf9405476044e988f385599d3ddcd0