Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Bianca Feyen"'
Autor:
Godelieve Lammens, Bianca Feyen, Petra Vinken, Jim Proctor, Mark D. Johnson, Rao N.V.S. Mamidi, Sandra De Jonghe
Publikováno v:
Chemico-Biological Interactions. 277:85-90
During preclinical development of canagliflozin, an SGLT2 inhibitor, treatment-related pheochromocytomas, renal tubular tumors (RTT), and testicular Leydig cell tumors were reported in the 2-year rat toxicology study. In a previous 6-month rat mechan
Autor:
Bianca Feyen, Adriana Looszova, Tim Erkens, Jill Witters, Liesbeth Van den Sande, Filip Verbraeken
Publikováno v:
Veterinary Clinical Pathology. 46:416-421
BACKGROUND A marked decrease in thrombocyte count was observed between subsequent measurements of the same EDTA blood sample in several minipigs, but little information was available explaining this finding. OBJECTIVES The objective was to evaluate t
Autor:
Bianca Feyen, Esther Moesen, Sandra De Jonghe, Petra Vinken, Lieve Lammens, David Abbott, Alexander de Lahunta, An Vynckier
Publikováno v:
Toxicologic Pathology. 43:1141-1148
This article describes the occurrence of a bilaterally symmetrical encephalopathy in Sprague-Dawley rats, which occurred over the period 2005 to 2012 in our laboratory in both untreated control rats and rats treated with different pharmacologically a
Autor:
Petra Vinken, Sandra De Jonghe, Jim Proctor, Mark D. Johnson, Bianca Feyen, Dirk Mariën, Helena Geys, Inneke Wynant, Rao N.V.S. Mamidi
Publikováno v:
Chemico-Biological Interactions. 224:1-12
The carcinogenicity potential of canagliflozin, an inhibitor of SGLT2, was evaluated in a 2-year rat study (10, 30, and 100 mg/kg). Rats showed an increase in pheochromocytomas, renal tubular tumors, and testicular Leydig cell tumors. Systemic exposu
Autor:
Lieve Dillen, Hans Stieltjes, Philip Timmerman, Bianca Feyen, Loeckie de Zwart, Tom Verhaeghe, Ann Vroman, Luc Diels
Publikováno v:
Bioanalysis. 9(7)
Aim: Capillary microsampling (CMS) to collect microplasma volumes is gradually replacing traditional, larger volume sampling from rats in GLP toxicology studies. Methodology: About 32 µl of blood is collected with a capillary, processed to plasma an
Autor:
Bianca Feyen, Sandra De Jonghe, Calvert Louden, Petra Vinken, Stewart Bryant, Godelieve Lammens, Rao N.V.S. Mamidi, Sandra Snook, Mark D. Johnson, Esther Moesen, Michael F. Kelley, Jim Proctor, Kirk Ways, Jing Ying Ma
Publikováno v:
Chemico-Biological Interactions. 221:109-118
Canagliflozin is an SGLT2 inhibitor used for the treatment of type 2 diabetes mellitus. Studies were conducted to investigate the mechanism responsible for renal tubular tumors and pheochromocytomas observed at the high dose in a 2-year carcinogenici
Autor:
Sandra De Jonghe, Edward Marsden, Maria Desmidt, Laure Penard, Marjolein van Heerden, Bianca Feyen, Pierluigi Fant, Graham Bailey, Sien Maki Mousa
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 64
For pediatric indications requiring juvenile toxicity testing, the rat is the preferred species. However, for some drugs it might not be an appropriate model or regulatory agencies may also request a non-rodent species. Due to the relatively recent u
Autor:
Kathleen Van den Bulck, Siegrid Damsch, Gary Eichenbaum, Elaine Knight, Alfred Tonelli, L. Lammens, Bianca Feyen, Adriana Looszova, Kelley Michael F
Publikováno v:
Toxicologic Pathology. 39:337-347
In a three-week oral gavage toxicity study in rats, a high incidence of respiratory symptoms and high mortality was noted in compound-dosed rats only. Because of audible respiration, an effect in the upper respiratory tract was suspected and the nasa
Autor:
Gary Eichenbaum, Alfred Tonelli, V. Hillsamer, Kelley Michael F, Siegrid Damsch, K. Van den Bulck, Anton Megens, Elaine Knight, John Vandenberghe, Adriana Looszova, Karen Roels, L. Lammens, Bianca Feyen
Publikováno v:
Journal of Applied Toxicology. 31:342-354
Unscheduled mortality preceded by adverse respiratory clinical signs in rats dosed by oral gavage may not only be caused by technical gavage error or systemic toxicity but may also be caused by gastro-esophageal reflux and subsequent aspiration of hi
Autor:
Boudewijn Catry, Bianca Feyen, Aart de Kruif, Geert Opsomer, Dominiek Maes, Tom Timmerman, Jeroen Dewulf
Publikováno v:
Preventive Veterinary Medicine. 74:251-263
To control the emergence of antimicrobial resistance, knowledge of antimicrobial drug consumption is essential. Because consumption data are not available in Belgium, a study was conducted between March and October 2003 to investigate the antimicrobi